CLINICAL TRIAL

The program Remédiation Cognitive de la Cognition Sociale en Schizophrénie (RC2S+) for Schizophrenia

Recruiting · 18+ · All Sexes · Montréal, Canada

This study is evaluating whether a cognitive remediation program can be delivered remotely.

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About the trial for Schizophrenia

Eligible Conditions
Cognitive Impairment (CI) · Schizophrenia · Psychosis

Treatment Groups

This trial involves 2 different treatments. The Program Remédiation Cognitive De La Cognition Sociale En Schizophrénie (RC2S+) is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

Main TreatmentA portion of participants receive this new treatment to see if it outperforms the control.
The program Remédiation Cognitive de la Cognition Sociale en Schizophrénie (RC2S+)
BEHAVIORAL
Control TreatmentAnother portion of participants receive the standard treatment to act as a baseline.

Eligibility

This trial is for patients born any sex aged 18 and older. There are 7 eligibility criteria to participate in this trial as listed below.

Inclusion & Exclusion Checklist
Mark “yes” if the following statements are true for you:
Being followed and treated by a clinician of the Douglas Mental Health University Hospital
Having an objective difficulty in social cognition (i.e. emotion recognition, theory of mind, attributional bias, social perception) defined as a performance equal of below 1 standard deviation from the normative group on one of the following measures: Penn Emotion Recognition Task (ER-40; Emotion recognition), Combined Stories Test (COST; Theory of mind), Social Knowledge test (SKT; Social knowledge) or Interpersonal, Personal and Situational Attributions Questionnaire (IPSAQ; Attributional style). This criterion is mandatory since we need to be able to remediate a difficulty during cognitive remediation.
Being considered symptomatically stable and capable of using the online platforms, as judged by their primary clinicians (i.e., psychiatrist, case manager, psychologist)
Having access to digital technology, Internet and access to a private space (a room where the participant can be alone)
DSM-5 diagnosis of schizophrenia or a related psychotic disorder
Being able to nominate an emergency contact
Being 18 or older
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Odds of Eligibility
Unknown<50%
Be sure to apply to 2-3 other trials, as you have a low likelihood of qualifying for this one.Apply To This Trial
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Approximate Timelines

Please note that timelines for treatment and screening will vary by patient
Screening: ~3 weeks
Treatment: varies
Reporting: The administration time is estimated at 30 minutes.
Screening: ~3 weeks
Treatment: Varies
Reporting: The administration time is estimated at 30 minutes.
This trial has approximate timelines as follows: 3 weeks for initial screening, variable treatment timelines, and reporting: The administration time is estimated at 30 minutes..
View detailed reporting requirements
Trial Expert
Connect with the researchersHop on a 15 minute call & ask questions about:
- What options you have available- The pros & cons of this trial
- Whether you're likely to qualify- What the enrollment process looks like

Measurement Requirements

This trial is evaluating whether The program Remédiation Cognitive de la Cognition Sociale en Schizophrénie (RC2S+) will improve 4 primary outcomes, 6 secondary outcomes, and 7 other outcomes in patients with Schizophrenia. Measurement will happen over the course of The administration time is estimated at 20 minutes..

PANSS-6: Positive and Negative Syndrome Scale
THE ADMINISTRATION TIME IS ESTIMATED AT 20 MINUTES.
Through a semi-structured interview, the positive and negative symptomatology of schizophrenia is explored. In this reduced scale, the following symptoms are assessed: delusions, conceptual disorganization, hallucinations, flattened affect, passive social withdrawal, and poverty of speech.
THE ADMINISTRATION TIME IS ESTIMATED AT 20 MINUTES.
First-episode social functioning scale (FESF)
THE ADMINISTRATION TIME IS ESTIMATED AT 10 MINUTES.
This self-report questionnaire aims to assess functioning in several areas including productive activities (e.g. school, work), social functioning (e.g. family, friends, acquaintances) and instrumental activities of daily living (e.g. transportation, money management). Items are rated on a Likert scale ranging from "completely disagree" to "completely agree" for the ability of the participant to perform the activity, and on a scale ranging from "Never" to "Always" for the frequency of the activity (with the option never if the activity is not performed by the participant).
THE ADMINISTRATION TIME IS ESTIMATED AT 10 MINUTES.
Échelle de repercussions fonctionnelles des troubles de la cognition sociale (ERF-CS)
THE ADMINISTRATION TIME IS ESTIMATED AT 10 MINUTES.
This short semi-structured interview explores the presence and impact of various social cognitive deficits in everyday life. The interview also assesses how much the participant is bothered by these difficulties.
THE ADMINISTRATION TIME IS ESTIMATED AT 10 MINUTES.
Interpersonal, Personal and Situational Attributions Questionnaire (IPSAQ)
THE ADMINISTRATION TIME IS ESTIMATED AT 10 MINUTES.
This test assesses attributional style. Participants are presented with 32 social situations and for each of them, they must decide what was the main cause of the event described in each statement and select if the cause is whether because of them, because of another person or because of the situation.
THE ADMINISTRATION TIME IS ESTIMATED AT 10 MINUTES.
DACOBS: Davos Assessment of Cognitive Biases Scale
THE ADMINISTRATION TIME IS ESTIMATED AT 10 MINUTES.
This questionnaire assesses cognitive biases through 42 items rated on a Likert scale from 1 (strongly disagree) to 7 (strongly agree).
THE ADMINISTRATION TIME IS ESTIMATED AT 10 MINUTES.
Penn Emotion Recognition Task (ER-40)
THE ADMINISTRATION TIME IS ESTIMATED AT 10 MINUTES.
This test assesses emotion recognition on faces. A total of 40 faces are presented to the participants who must choose between five different emotions.
THE ADMINISTRATION TIME IS ESTIMATED AT 10 MINUTES.
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Who is running the study

Principal Investigator
M. L.
Prof. Martin Lepage, Clinical professor
McGill University

Patient Q & A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Can schizophrenia be cured?

It seems like most people want to be cured to no avail. No cure is forthcoming. We should not try to cure schizophrenia with drugs we don't have in medicine; we have to use them correctly. And we can't cure schizophrenia because we don't have the right 'tool'. The right tools we need are: 1. The right tools: antipsychotics. 2. The right indications: schizophrenia which hasn't gotten cured with antipsychotics 3. The right dosage: 50mg or less if you have it, and 25 if you don't.

Anonymous Patient Answer

What causes schizophrenia?

Although other causes than genes are involved in schizophrenia, this disease does have an important genetic component, which explains why relatives of people with schizophrenia are also likely to develop the disorder. It is believed that it is likely that one or more environmental factors, probably in early life, causes psychosis by acting on several genes involved in brain development. However the exact chain of cause and effect is unclear. There is also evidence from epidemiological research, which suggests that a mixture of genetic and environmental factors may affect risk. The link between schizophrenia and schizophrenia spectrum disorders and alcoholism is of interest, because a substance found in the brains of people with schizophrenia may also make them more likely to have alcoholism.

Anonymous Patient Answer

How many people get schizophrenia a year in the United States?

The high estimated incidence rate (24 per 100,000) of schizophrenia in the US is unlikely to be due to underdiagnosis. Thus, the incidence of schizophrenia in the US, although possibly overestimated, may be higher then previously thought.

Anonymous Patient Answer

What is schizophrenia?

Being able to accurately classify which symptoms are normal and different signs of schizophrenia, schizophrenia can help guide proper diagnosis and treatment. We argue that the two core symptoms experienced by patients with schizophrenia are positive and negative hallucinations and delusions. However, not enough research has been conducted on whether hallucinations in schizophrenia are specific to positive symptoms or can also accompany other symptoms such as disorganized speech, disorganized behavior, or abnormal thinking. However, studies suggest that positive hallucinations are most common in auditory hallucinations while negative hallucinations, especially in the visual perceptual realm are more common in delusions of reference. The authors of this paper present specific ways of assessing the core symptoms of schizophrenia to make sure the symptoms are present.

Anonymous Patient Answer

What are the signs of schizophrenia?

There is no consensus, although there were some commonly accepted signs, in literature, for schizophrenia. In this paper I discuss the signs currently accepted as manifestations of schizophrenia. (d)\n\n- Inability to express one's thoughts and feelings because of lack of appropriate or appropriate words.

Anonymous Patient Answer

What are common treatments for schizophrenia?

There is not one specific treatment for schizophrenia that works for all patients. In view of this, treatment with antipsychotic medication alone is generally preferred in patients with schizophrenia.

Anonymous Patient Answer

How serious can schizophrenia be?

In a recent study, findings provides further evidence for strong correlations between psychotic symptoms and impairment on everyday functions in people with schizophrenia and for their potential value as a proxy measure of a patient's functional status. These correlations are much stronger than the relationships of these symptoms to other clinical characteristics such as IQ and medication adherence/nonadherence. The implications of these findings for clinical practice, research, and treatment models are discussed.

Anonymous Patient Answer

What does the program remédiation cognitive de la cognition sociale en schizophrénie (rc2s+) usually treat?

In order to effectively treat these patients some new ways to monitor, monitor, and treat should be discovered. At the moment this only goes as far as treatment is concerned.

Anonymous Patient Answer

What is the average age someone gets schizophrenia?

The average age at onset of schizophrenia was 22.3years (age range 7-60years). There was a gender difference in the age at onset between men (mean of 19.0years) and women (mean of 32.2years). We found a significantly higher prevalence of menopause (p=0.0426) in a large Swedish cohort of psychiatric cases (n=947). In our clinic, the women are having a more severe and long-lasting course of schizophrenia than men (average course duration 4.8 and 2.3years respectively). Female patients have been described having early and long-lasting course schizophrenia due to different mechanisms of action during the process of sexual maturity.

Anonymous Patient Answer

Is the program remédiation cognitive de la cognition sociale en schizophrénie (rc2s+) safe for people?

The rcs2s program is safe for people with schizophrenia as safety indicators were not impacted by an active participation of the participants in group work. This indicates that the program can potentially benefit those who were excluded due to lack of resources.

Anonymous Patient Answer

Have there been any new discoveries for treating schizophrenia?

While there are several treatments for different aspects of the schizophrenic syndrome, there are still no medications for all symptoms. At present, one needs a combination of treatments to effectively manage symptoms. In the United States, medications such as antipsychotics, antidepressants, and anxiolytics are the drugs of choice. Other treatments may include electroconvulsive therapy, antipsychotic-sparing drugs, atypical antipsychotics, antidepressants, and antihypertensives. It is important that these drugs are used appropriately and in the correct amounts, as one needs to weigh the risks and benefits of the different treatments before embarking on a course of treatment. This is why I believe that collaborative treatments are the way we must approach this devastating illness.

Anonymous Patient Answer

Has the program remédiation cognitive de la cognition sociale en schizophrénie (rc2s+) proven to be more effective than a placebo?

Findings from a recent study suggest that the program 2x3 is more effective than a placebo in relieving behavioural symptoms of psychosis. However, in clinical practice, 2x3 appears to be an effective treatment to a limited population of patients. Its efficiency is enhanced by additional cognitive exercises that aim at improving motivation to complete 2x3.

Anonymous Patient Answer
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