← Back to Search

Unknown

APG-2575 for Blood Cancers

Phase < 1
Recruiting
Research Sponsored by Ascentage Pharma Group Inc.
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Eastern Cooperative Oncology Group (ECOG) Performance Status (PS): 0 -1 in dose escalation ; 0-2 in dose expansion.
Histologically confirmed diagnosis of either one of the B-cell hematologic malignancies including multiple myeloma, chronic lymphocytic leukemia, lymphoplasmacytic lymphoma, and non-Hodgkin's lymphoma such as mantle cell lymphoma, diffuse large B cell lymphoma, Waldenstrom macroglobulinemia (WM) and acute myeloid leukemia
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 2 years
Awards & highlights

Study Summary

This trial is testing a new cancer drug, APG-2575, to see if it is safe and effective.

Who is the study for?
This trial is for adults over 18 with certain blood cancers like multiple myeloma, chronic lymphocytic leukemia, and non-Hodgkin's lymphoma who haven't responded to or can't have standard treatments. They should expect to live at least 3 more months, be relatively active (able to care for themselves), and have a minimum level of white blood cells, hemoglobin, and platelets.Check my eligibility
What is being tested?
The study is testing APG-2575's safety and how well it works in two stages: first finding the right dose and then seeing its effects on a larger group. It's an open-label trial which means everyone knows they're getting APG-2575; there’s no placebo.See study design
What are the potential side effects?
Specific side effects of APG-2575 aren’t listed here but generally could include symptoms like nausea, fatigue, allergic reactions or other drug-specific adverse events that will be monitored throughout the trial.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am fully active or restricted in physically strenuous activity but can do light work.
Select...
I have been diagnosed with a specific type of blood cancer.
Select...
My condition hasn't improved with standard treatments, or I can't tolerate them.
Select...
I have AML and standard treatments haven't worked or aren't suitable for me.
Select...
I am 18 years old or older.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 2 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 2 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Maximum Tolerated Dose (MTD)
Secondary outcome measures
Anti-tumor effects of APG-2575
Area under the plasma concentration versus time curve (AUC)
Maximum plasma concentration (Cmax)

Trial Design

1Treatment groups
Experimental Treatment
Group I: single-agent, open-label, Phase I study of APG-2575Experimental Treatment1 Intervention
The study consists of the dose escalation stage and the dose expansion stage

Find a Location

Who is running the clinical trial?

Ascentage Pharma Group Inc.Lead Sponsor
46 Previous Clinical Trials
4,244 Total Patients Enrolled
Yifan Zhai, MD, PhDStudy ChairAscentage Pharma Group Inc.
18 Previous Clinical Trials
1,216 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there opportunities for individuals to participate in this research?

"Affirmative. Clinicaltrials.gov reveals that this trial, created on August 7th 2018, is recruiting participants as of today. 90 individuals need to be enrolled across 4 sites."

Answered by AI

How many individuals are being enrolled in this examination?

"To commence the trial, 90 qualifying individuals are needed. Ascentage Pharma Group Inc., is responsible for operating said study; and it will occur across multiple sites such as Duke University in Jacksonville and MDACC in Durham, North carolina."

Answered by AI

Could you provide a count of the centers hosting this experiment in town?

"Currently, 4 sites are accepting patient enrolment. These locations sit in Jacksonville, Durham and Houston with additional locations located nearby to minimise travel for those who join the trial."

Answered by AI
~6 spots leftby Sep 2024