Tirzepatide for Obesity
This study is evaluating whether a drug called tirzepatide can help people lose weight.
See full descriptionAbout the trial for Obesity
Treatment Groups
This trial involves 4 different treatments. Tirzepatide is the primary treatment being studied. Participants will be divided into 3 treatment groups. Some patients will receive a placebo treatment. The treatments being tested are in Phase 3 and have had some early promising results.
About The Treatment
Side Effect Profile for 5 mg Tirzepatide
Eligibility
This trial is for patients born any sex aged 18 and older. There are 2 eligibility criteria to participate in this trial as listed below.
Approximate Timelines
Measurement Requirements
This trial is evaluating whether Tirzepatide will improve 23 secondary outcomes in patients with Obesity. Measurement will happen over the course of Baseline, Week 20.
Patient Q & A Section
What is obesity?
Obesity is not just a social problem; it is a medical problem, too, because obesity is associated with other health problems. Obesity also has a big impact on the economy. The impact exceeds that of smoking. It is estimated that obesity has a cost-of-illness of $147 billion per year nationwide. The health-care costs in the U.S. have climbed at a rate of 4.5% per year since 1999, in part due to the increasing number of patients. Overall, obesity is the most economically detrimental disease in the U.S., contributing to more than $80 billion in health-care expenditures each year.
Can obesity be cured?
Based on our case studies we can say that in some people it can be cured so long as it is not done by overeating or skipping meals. In others the eating habits are always there. In others people make a sincere effort and lose weight, but not only do they become leaner by their own standards, they often don't keep track of their eating habits. Some people find all this too confusing and feel they must rely on somebody else or some pill to fix their eating habits. A person is at their best when they are trying to have an active lifestyle but at the same time, if they want to lose weight they need to work on balancing eating and exercising with a healthy lifestyle.
What are the signs of obesity?
Obesity commonly affects a person's health in a number of ways including a decrease in muscle strength and the increase in fat volume. The physical impact of obesity may also include a reduced lifespan, the development of diabetes mellitus, and increased risk of cardiovascular disease. There are over 340 different health risks that are associated with obesity. The signs of obesity range from having no symptoms to being very obvious on an individual. The signs are not always in the most obvious parts of the body, as they may appear in any part.
How many people get obesity a year in the United States?
There is no consistent, annual increase in the prevalence of obesity in the United States. The increase in obesity during the past decade appears to be more pronounced among adolescents than adults and in women than men.
What causes obesity?
At least two-thirds of overweight and three-quarters of obesity people are unable to lose weight on their own. It seems most appropriate to offer behavioural modification treatments, with or without medication when appropriate, to those who present with a BMI >27 kg/m(2) and who have a Body Mass Index >26 kg/m(2) or a Body Weight >10th centile in a male or in a female.
What are common treatments for obesity?
There is a significant need for effective and safe bariatric surgery for the obesity epidemic. There is presently insufficient evidence to indicate the role that surgical, medical and interventional therapies may play in facilitating weight loss.
How serious can obesity be?
Obesity is a common disorder that dramatically increases the risk for several diseases, including coronary artery disease and stroke, and accounts for much of the excess mortality seen in men and women. Obese people who are treated and stay severely obese have improved long-term prognoses. Because overweight and obese men have increased mortality, the public health implications of obesity extend well beyond a healthy weight range. A simple BMI cutoff for the public and clinical workforce might be advisable, in order to promote early and appropriate management.
How does tirzepatide work?
Tirzepatide reduces apoptosis and inflammation of T2D in high-fat-fed mice. Tirzepatide acts through suppression NF-kappaB binding. Tirzepatide may represent a promising novel treatment for T2D.
Who should consider clinical trials for obesity?
There are clear barriers both in medical professionals and in patients for participation in clinical trials of obesity treatments. However, there has been no clear evidence that these barriers affect treatment outcomes and some patients do find benefit. The need for a standardized, valid, and ethical approach to clinical trials with obese patients is now undeniable.
What is the primary cause of obesity?
All subjects with obesity are likely to have a strong dietary addiction. Over 50% of overweight women will be at greater risk for being obese if they continue to eat a large amount of sugar.
Is tirzepatide typically used in combination with any other treatments?
Tirzepatide has been used in combination with other nonvitamin D3 agents in a minority of patients. Our preliminary data lend further support to the hypothesis that a larger fraction of patients benefit from tirzepatide use in combination with other therapies.
Does tirzepatide improve quality of life for those with obesity?
Tirzepatide improved quality of life and body image in obese patients, suggesting that an optimal dose of this novel peptide could be defined for this population.