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Tetracycline Antibiotic

Minocycline for High Blood Pressure

Phase 2

Waitlist Available

Led By Carl Pepine, MD

Research Sponsored by University of Florida

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up change in baseline to 24 weeks

Awards & highlights

Study Summary

This trial will test whether minocycline, which is used to treat hypertension, is associated with a decrease in activated microglia in central nervous system autonomic regions.

Who is the study for?

This trial is for individuals with drug-resistant high blood pressure who are already part of another study (NCT02133885). Participants must be willing to travel to Montreal, Canada for brain imaging and testing. They should not be pregnant or have been so in the last 6 months, nor taking certain medications that could affect the study's outcome.Check my eligibility

What is being tested?

The trial is studying whether Minocycline can lower blood pressure by reducing microglia activation in the brain. This will be measured using advanced imaging techniques like PET and MRI scans alongside Autonomic Nervous System Testing.See study design

What are the potential side effects?

While specific side effects are not listed here, Minocycline commonly causes dizziness, fatigue, headache, unsteadiness, and may affect digestion. It can also lead to changes in skin color and serious allergic reactions.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ change in baseline to 24 weeks

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~change in baseline to 24 weeks

This trial's timeline: 3 weeks for screening, Varies for treatment, and change in baseline to 24 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

MRI changes in the paraventricular nucleus

PET changes in the paraventricular nucleus

Side effects data

From 2016 Phase 4 trial • 10 Patients • NCT02124811

40%

Inpatient psychiatric hospitalization

20%

Hospitalization due to ischemic colitis

20%

Hypotension

100%

80%

60%

40%

20%

Study treatment Arm

Low CRP

High CRP

Trial Design

1Treatment groups

Experimental Treatment

Group I: MinocyclineExperimental Treatment1 Intervention

Subjects will receive the dose of Minocycline determined to best lower BP and will undergo baseline and week 12-24 follow-up MRI and PET scans for changes in the paraventricular nucleus.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Minocycline

2005

Completed Phase 4

~1000

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

University of FloridaLead Sponsor

1,340 Previous Clinical Trials

715,696 Total Patients Enrolled

National Heart, Lung, and Blood Institute (NHLBI)NIH

3,835 Previous Clinical Trials

47,310,633 Total Patients Enrolled

Carl Pepine, MDPrincipal InvestigatorUniversity of Florida

6 Previous Clinical Trials

216 Total Patients Enrolled

Media Library

Minocycline (Tetracycline Antibiotic) Clinical Trial Eligibility Overview. Trial Name: NCT02213575 — Phase 2

High Blood Pressure Research Study Groups: Minocycline

High Blood Pressure Clinical Trial 2023: Minocycline Highlights & Side Effects. Trial Name: NCT02213575 — Phase 2

Minocycline (Tetracycline Antibiotic) 2023 Treatment Timeline for Medical Study. Trial Name: NCT02213575 — Phase 2

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the main reason that doctors prescribe this medication?

"Doxycycline is often used to treat rocky mountain spotted fever, but can also be helpful in treating q fever, dental root planing, and respiratory tract infections."

Answered by AI

Do we have a history of this type of treatment being successful?

"As of this date, there are a total of 21 ongoing clinical trials for this intervention. Out of these, 6 are in Phase 3. The epicentre for these studies is Guangzhou in Guangdong province. Although, it's worth mentioning that 37 different locations around the world are running similar investigations."

Answered by AI

Is this research project available to people who are over 25 years old?

"The age bracket for this study includes any person who is over 18 and less than 85 years old."

Answered by AI

Are there still spots open for patients who want to enroll in this research?

"This particular study has stopped recruiting patients. The trial began on April 15th 2023 and ended on September 16th 2022. However, there are 785 other trials for hypertension that are ongoing and 21 of those studies are currently enrolling new participants."

Answered by AI

Could I qualify to take part in this experiment?

"This study looking for 9 individuals that suffer from hypertension. The eligible age range is 18 to 85 years old. It's worth mentioning that participants must be willing to go to Montreal, Canada for specialized brain scans using MRI and PET if they qualify for the study. Also, subjects who are already participating in IRB approved protocol #102-2013 will be able to join this trial."

Answered by AI

Has this medication been cleared by the FDA?

"While there is some evidence that this treatment is safe, it only exists in Phase 2 trials. This means that, while there may be data supporting safety, there is none yet which suggests that the treatment is effective."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Study 3: Minocycline Decreases Microglia Activation

2024. "Study 3: Minocycline Decreases Microglia Activation". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02213575.

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