Minocycline for High Blood Pressure
What You Need to Know Before You Apply
What is the purpose of this trial?
This study is a mechanistic study that will enroll 9 subjects who are participating in NCT02133872 (which is designed to evaluate minocycline to test the hypothesis that minocycline treatment would produce antihypertensive effects in drug-resistant neurogenic hypertensive individuals) to test whether the antihypertensive effect of minocycline is associated with a decrease in activated microglia in central nervous system autonomic regions as evidenced by changes in PET and MRI imaging.
Do I need to stop taking my current medications for the trial?
Yes, you will need to stop taking certain medications, such as antibiotics, anti-inflammatory agents, and immune-modulating medications, before joining the trial.
Is minocycline safe for use in humans?
Who Is on the Research Team?
Carl Pepine, MD
Principal Investigator
University of Florida
Are You a Good Fit for This Trial?
This trial is for individuals with drug-resistant high blood pressure who are already part of another study (NCT02133885). Participants must be willing to travel to Montreal, Canada for brain imaging and testing. They should not be pregnant or have been so in the last 6 months, nor taking certain medications that could affect the study's outcome.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive Minocycline and undergo baseline and follow-up MRI and PET scans
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Minocycline
Minocycline is already approved in United States, European Union, Japan, India for the following indications:
- Acne
- Bacterial infections
- Periodontal disease
- Rosacea
- Acne
- Bacterial infections
- Bacterial infections
- Acne
- Rosacea
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Florida
Lead Sponsor
National Heart, Lung, and Blood Institute (NHLBI)
Collaborator