Anti-hypertensive agent: amlodipine for High Blood Pressure

University of California San Francisco, San Francisco, CA
High Blood PressureAnti-hypertensive agent: amlodipine - Drug
Eligibility
18 - 35
All Sexes
What conditions do you have?
Select

Study Summary

This trial will test different ways to lower blood pressure, including medication and engagement strategies, to see what works best. Quality of life and adverse events will also be monitored.

Treatment Effectiveness

Phase-Based Effectiveness

1 of 3
Phase 2 & 3

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1
Perindopril
2
Telmisartan 10 mg/amlodipine 1.25 mg/indapamide 0.625 mg
2
Telmisartan 20 mg/amlodipine 2.5 mg/indapamide 1.25 mg

Study Objectives

1 Primary · 1 Secondary · Reporting Duration: Month 6

Month 0
Adherence to home BP monitoring
Month 6
Achieved systolic blood pressure

Trial Safety

Phase-Based Safety

2 of 3
This is further along than 68% of similar trials

Similar Trials

2
Perindopril
3
Telmisartan 10 mg/amlodipine 1.25 mg/indapamide 0.625 mg
3
Telmisartan 20 mg/amlodipine 2.5 mg/indapamide 1.25 mg

Awards & Highlights

No Placebo Group
All patients enrolled in this trial will receive the new treatment.

Trial Design

9 Treatment Groups

Amlodipine 2.5 mg + Home BP monitoring with cuffed device
1 of 9
amlodipine 2.5 mg daily + home BP monitoring with watch
1 of 9
amlodipine 2.5 mg daily + home BP monitoring with patch
1 of 9
Chlorthalidone 12.5 mg + Home BP monitoring with cuffed device
1 of 9
Chlorthalidone 12.5 mg daily + home BP monitoring with patch
1 of 9
Losartan 12.5 mg daily + home BP monitoring with cuffed device
1 of 9
Losartan 12.5 mg daily + home BP monitoring with patch
1 of 9
chlorthalidone 12.5 mg daily + home BP monitoring with watch
1 of 9
losartan 12.5 mg daily + home BP monitoring with watch
1 of 9

Active Control

Experimental Treatment

120 Total Participants · 9 Treatment Groups

Primary Treatment: Anti-hypertensive agent: amlodipine · No Placebo Group · Phase 2 & 3

amlodipine 2.5 mg daily + home BP monitoring with watchExperimental Group · 2 Interventions: Home BP monitoring with cuffed device + BP watch, Anti-hypertensive agent: amlodipine · Intervention Types: Device, Drug
amlodipine 2.5 mg daily + home BP monitoring with patchExperimental Group · 2 Interventions: Home BP monitoring with cuffed device + BP patch, Anti-hypertensive agent: amlodipine · Intervention Types: Device, Drug
Chlorthalidone 12.5 mg + Home BP monitoring with cuffed deviceExperimental Group · 2 Interventions: Home BP monitoring with cuffed device, Anti-hypertensive agent: Chlorthalidone · Intervention Types: Device, Drug
Chlorthalidone 12.5 mg daily + home BP monitoring with patchExperimental Group · 2 Interventions: Home BP monitoring with cuffed device + BP patch, Anti-hypertensive agent: Chlorthalidone · Intervention Types: Device, Drug
Losartan 12.5 mg daily + home BP monitoring with cuffed deviceExperimental Group · 2 Interventions: Home BP monitoring with cuffed device, Anti-hypertensive agent: Losartan · Intervention Types: Device, Drug
Losartan 12.5 mg daily + home BP monitoring with patchExperimental Group · 2 Interventions: Home BP monitoring with cuffed device + BP patch, Anti-hypertensive agent: Losartan · Intervention Types: Device, Drug
chlorthalidone 12.5 mg daily + home BP monitoring with watchExperimental Group · 2 Interventions: Home BP monitoring with cuffed device + BP watch, Anti-hypertensive agent: Chlorthalidone · Intervention Types: Device, Drug
losartan 12.5 mg daily + home BP monitoring with watchExperimental Group · 2 Interventions: Home BP monitoring with cuffed device + BP watch, Anti-hypertensive agent: Losartan · Intervention Types: Device, Drug
Amlodipine 2.5 mg + Home BP monitoring with cuffed deviceActiveComparator Group · 2 Interventions: Home BP monitoring with cuffed device, Anti-hypertensive agent: amlodipine · Intervention Types: Device, Drug

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: month 6

Who is running the clinical trial?

University of California, San FranciscoLead Sponsor
2,346 Previous Clinical Trials
11,782,592 Total Patients Enrolled
Elaine Ku, MD MASPrincipal InvestigatorUniversity of California, San Francisco
1 Previous Clinical Trials
200 Total Patients Enrolled

Eligibility Criteria

Age 18 - 35 · All Participants · 0 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:

Who else is applying?

What state do they live in?
California100.0%
What portion of applicants met pre-screening criteria?
Did not meet criteria100.0%
References

Frequently Asked Questions

Can people of all ages participate in this research?

"This specific clinical trial is only for patients aged 18 to 35. However, there are a total of 56 trials for patients under 18 and 693 trials for senior citizens aged 65 and up." - Anonymous Online Contributor

Unverified Answer

For whom is this trial designed?

"This study is looking for 120 young adults, aged 18-35, who suffer from hypertension or are receiving treatment for high blood pressure. Additionally, these participants must have home blood pressure readings that meet the definition of hypertension (>=125/80 mmHg)." - Anonymous Online Contributor

Unverified Answer

Are we still enrolling people in this trial?

"That is correct. As of today, the clinical trial mentioned is still recruiting patients. The original posting was on April 15th, 2022 and there have been no updates since May 6th, 2022. So far, only 1 site has been enrolling the desired 120 patients." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

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