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Anti-inflammatory

Minocycline Hydrochloride for Hypertension

Phase 4

Waitlist Available

Led By Steven M Smith, PharmD, MPH

Research Sponsored by University of Florida

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Uncontrolled TRH, defined as uncontrolled blood pressure (mean 24-hour ambulatory systolic BP ≥125 mm Hg or diastolic BP ≥80 mm Hg) while being adherent to a stable (no changes in ≥30 days prior) antihypertensive regimen of 3 or more drugs, including an adequately dosed thiazide or thiazide-like diuretic (hydrochlorothiazide ≥25 mg/day or equivalent)

Age ≥18 years

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 3 months

Awards & highlights

Study Summary

This trial aims to understand how minocycline affects blood pressure in people with treatment-resistant hypertension. It will investigate the extent to which minocycline lowers blood pressure and whether this effect varies among

Who is the study for?

This trial is for individuals with high blood pressure that doesn't get better with treatment. Participants will be studied to see how minocycline affects their condition, considering factors like race and changes in gut health.Check my eligibility

What is being tested?

The study tests if minocycline can lower blood pressure in resistant cases over a 3-month period, compared to a placebo. It also explores whether the effects are due to changes in gut bacteria, inflammation or other factors.See study design

What are the potential side effects?

Minocycline may cause side effects such as dizziness, fatigue, gastrointestinal issues, skin reactions and possibly affect the balance of gut bacteria.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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My high blood pressure is not controlled despite taking three or more blood pressure medications.

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I am 18 years old or older.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 3 months

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~3 months

This trial's timeline: 3 weeks for screening, Varies for treatment, and 3 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

24-h systolic blood pressure

Gut inflammation and leakiness

Gut microbiome

+1 more

Secondary outcome measures

24-h diastolic blood pressure

24-h heart rate

Adverse Events

+3 more

Side effects data

From 2016 Phase 2 trial • 47 Patients • NCT02297412

Fatigue

Lymphocyte count decreased

Diarrhea

Thromboembolic event

Abdominal pain

Back pain

Dizziness

Lung infection

100%

80%

60%

40%

20%

Study treatment Arm

Arm I (Minocycline Hydrochloride)

Arm II (Placebo)

Trial Design

2Treatment groups

Experimental Treatment

Placebo Group

Group I: Minocycline HydrochlorideExperimental Treatment1 Intervention

Minocycline hydrochloride 100 mg, administered twice daily for 3 months

Group II: PlaceboPlacebo Group1 Intervention

Placebo administered twice daily for 3 months

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Minocycline Hydrochloride

2018

Completed Phase 4

~90

0 / 2Eligibility criteria met

Find a Location

Who is running the clinical trial?

National Heart, Lung, and Blood Institute (NHLBI)NIH

3,843 Previous Clinical Trials

47,816,988 Total Patients Enrolled

469 Trials studying Hypertension

2,692,275 Patients Enrolled for Hypertension

University of FloridaLead Sponsor

1,342 Previous Clinical Trials

715,553 Total Patients Enrolled

32 Trials studying Hypertension

51,128 Patients Enrolled for Hypertension

Emory UniversityOTHER

1,642 Previous Clinical Trials

2,563,782 Total Patients Enrolled

30 Trials studying Hypertension

13,604 Patients Enrolled for Hypertension

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the safety considerations for individuals using Minocycline Hydrochloride?

"According to our assessment at Power, the safety rating for Minocycline Hydrochloride is graded as 3 due to its Phase 4 status, indicating official approval for this therapy."

Answered by AI

Do participants aged 60 and above qualify for enrollment in this research study?

"Recruitment for this clinical research study is targeting individuals over 18 years and below 85 years of age."

Answered by AI

Are researchers currently recruiting participants for this ongoing medical study?

"Based on the information from clinicaltrials.gov, this particular trial is not currently seeking participants. It was originally listed on April 1st, 2024, with the latest update made on January 30th, 2024. Despite its current inactivity for recruitment, there are a total of 712 active trials actively looking for eligible candidates at present."

Answered by AI

What are the primary goals of this experiment?

"The primary aim of this investigation, to be assessed over a period of around 3 months, is the assessment of gut inflammation and permeability. Secondary goals encompass evaluating adverse events- characterized as occurrences related to treatment, markers for gut leakiness - involving changes in lipocalin-2, intestinal fatty-acid binding protein (I-FABP), zonulin, and lipopolysaccharides (LPS), alongside assessing alterations in mean 24-hour diastolic blood pressure."

Answered by AI

Do I meet the necessary criteria to participate in this research endeavor?

"To be eligible for this research study, individuals must have a diagnosis of hypertension and be between 18 and 85 years old. The trial aims to enroll approximately 120 participants."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Antihypertensive Mechanisms of Minocycline in Resistant Hypertension

2024. "Antihypertensive Mechanisms of Minocycline in Resistant Hypertension". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT06246396.

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