Theta-burst Stimulation for Memory Improvement in Mild Cognitive Impairment
Trial Summary
What is the purpose of this trial?
The purpose of this study is to see if stimulation of the brain can improve memory. The investigators will use a device called transcranial magnetic stimulation that can stimulate and activate a specific part of the brain that is important for memory. The study will enroll MCI subjects and subjects with subjective memory complaints who will be randomly assigned to receive active or sham brain stimulation. 'Blinded' or 'sham-controlled' means that the subject will not know whether the treatment they receive is the active treatment or the non-active stimulation. In the 'sham' condition, the stimulator will turn on but will not actually be stimulating the target brain region.
Will I have to stop taking my current medications?
The trial requires that you do not change your use of medications for depression, anxiety, ADHD, or psychosis for one month before and during the study. If you are taking certain medications like anticholinergics, sedating antihistamines, or benzodiazepines, you may need to stop or adjust them, but this will be decided on a case-by-case basis.
What data supports the effectiveness of this treatment for memory improvement in mild cognitive impairment?
Research suggests that theta burst stimulation (TBS) can improve memory and brain connectivity in people with mild cognitive impairment (MCI). Additionally, similar treatments have shown promise in reducing Alzheimer's disease symptoms in animal studies, indicating potential benefits for memory-related conditions.12345
Is theta-burst stimulation (TBS) safe for humans?
How does theta-burst stimulation differ from other treatments for mild cognitive impairment?
Research Team
Nanthia Suthana
Principal Investigator
University of California, Los Angeles
Eligibility Criteria
This trial is for individuals aged 55-90 with mild cognitive impairment, who are in good health, right-handed, and speak English fluently. They should have memory complaints verified by specific tests and be able to consent to a long-term study. Excluded are those with dementia, major psychiatric or neurological disorders, substance abuse issues, certain medication use, or contraindications to MRI.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive either active or sham transcranial magnetic stimulation to improve memory
Follow-up
Participants are monitored for safety and effectiveness after treatment
Long-term follow-up
Participants undergo additional assessments to evaluate long-term effects of the treatment
Treatment Details
Interventions
- Active Theta Burst Stimulation
- Sham Theta Burst Stimulation
- Theta Burst Stimulation
Active Theta Burst Stimulation is already approved in United States, European Union, Canada for the following indications:
- Major Depressive Disorder
- Obsessive-Compulsive Disorder
- Migraines
- Major Depressive Disorder
- Obsessive-Compulsive Disorder
- Major Depressive Disorder
- Obsessive-Compulsive Disorder
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of California, Los Angeles
Lead Sponsor
National Institute on Aging (NIA)
Collaborator