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Imaging Biomarkers for Lung Cancer

N/A

Recruiting

Led By Kemp H Kernstine, MD

Research Sponsored by University of Texas Southwestern Medical Center

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Patients must have known or probable malignant lesions requiring surgical biopsy or excision.

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up during the infusion period blood samples will be collected every 30 minutes (for 2-3 hours) until the end of tumor sampling for mass spec and nmr analyisis of c-glucose in the blood.

Awards & highlights

Study Summary

This trial is looking at using MRI to study how a mass in the lung metabolizes sugar.

Who is the study for?

This trial is for adults over 18 with known or suspected malignant lung lesions that need surgical removal. It's open to all races and ethnicities. People with poorly controlled diabetes or those who are not suitable for surgery cannot participate.Check my eligibility

What is being tested?

The study aims to use MRI scans, along with a special sugar solution (13C-glucose), to understand how lung tumors metabolize sugar. Researchers will analyze tumor samples post-surgery to learn about the metabolic pathways of cancer growth.See study design

What are the potential side effects?

Since this trial involves standard MRI imaging and analysis of surgically removed tissue, there are no direct side effects from drugs being tested; however, typical risks associated with MRIs and surgeries apply.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I need surgery to remove or biopsy a suspected cancerous lesion.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ during the infusion period blood samples will be collected every 30 minutes (for 2-3 hours) until the end of tumor sampling for mass spec and nmr analyisis of c-glucose in the blood.

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~during the infusion period blood samples will be collected every 30 minutes (for 2-3 hours) until the end of tumor sampling for mass spec and nmr analyisis of c-glucose in the blood.

This trial's timeline: 3 weeks for screening, Varies for treatment, and during the infusion period blood samples will be collected every 30 minutes (for 2-3 hours) until the end of tumor sampling for mass spec and nmr analyisis of c-glucose in the blood. for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

DCE-MRI

Secondary outcome measures

C-13 isotopomer

Trial Design

1Treatment groups

Experimental Treatment

Group I: SurgeryExperimental Treatment1 Intervention

The 13C-glucose solution will be given intravenously. It will be started at about the same time as the start of surgery, according to the study guidelines. The 13C-glucose IV solution will be stopped once the surgeon has removed the tumor tissue.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Imaging Biomarkers

2021

N/A

~50

0 / 1Eligibility criteria met

Find a Location

Who is running the clinical trial?

University of Texas Southwestern Medical CenterLead Sponsor

1,047 Previous Clinical Trials

1,053,599 Total Patients Enrolled

Kemp H Kernstine, MDPrincipal InvestigatorUniversity of Texas Southwestern Medical Center

Media Library

Imaging Biomarkers Clinical Trial Eligibility Overview. Trial Name: NCT02095808 — N/A

Lung Cancer Research Study Groups: Surgery

Lung Cancer Clinical Trial 2023: Imaging Biomarkers Highlights & Side Effects. Trial Name: NCT02095808 — N/A

Imaging Biomarkers 2023 Treatment Timeline for Medical Study. Trial Name: NCT02095808 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there any available openings in this research endeavor?

"Affirmative. Data hosted on clinicaltrials.gov shows that this medical study, initiated on March 20th 2013, is currently enrolling participants. 225 patients are needed at a single location."

Answered by AI

What is the cap on patient enrollment in this clinical trial?

"Right. According to clinicaltrials.gov, this trial is actively enrolling participants since its initial posting on March 20th 2013 and was most recently updated on April 28th 2022. The investigators need to find 225 patients at one location for the experiment."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Metabolic Biomarkers in Thoracic Cancers

Kemp Kernstine 2013. "Metabolic Biomarkers in Thoracic Cancers". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02095808.

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