CLINICAL TRIAL

Continuous Positive Airway Pressure for Cancer

Recruiting · 18+ · All Sexes · Houston, TX

This study is evaluating whether a continuous positive airway pressure device or deep inspiration breath hold works in reducing tumor movement in patients undergoing stereotactic body radiation therapy (SBRT) for lung

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About the trial for Cancer

Eligible Conditions
Malignant Respiratory Tract Neoplasm · Neoplasms · Lung, Carcinoma · Respiratory Tract Neoplasms · Metastatic Malignant Neoplasm in the Lung

Treatment Groups

This trial involves 2 different treatments. Continuous Positive Airway Pressure is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are in Phase 1 & 2 and have already been tested with other people.

Main TreatmentA portion of participants receive this new treatment to see if it outperforms the control.
Stereotactic Body Radiation Therapy
RADIATION
Computed Tomography
PROCEDURE
Biphasic Positive Airway Pressure
DEVICE
Continuous Positive Airway Pressure
PROCEDURE
Radiation Therapy Treatment Planning and Simulation
RADIATION
Deep Inspiration Breath Hold
PROCEDURE
Control TreatmentAnother portion of participants receive the standard treatment to act as a baseline.

About The Treatment

Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Stereotactic Body Radiation Therapy
2016
Completed Phase 2
~560
Computed Tomography
2017
Completed Phase 2
~3460
Continuous Positive Airway Pressure
2016
Completed Phase 3
~1350
Radiation Therapy Treatment Planning and Simulation
2014
N/A
~10

Eligibility

This trial is for patients born any sex aged 18 and older. There are 2 eligibility criteria to participate in this trial as listed below.

Inclusion & Exclusion Checklist
Mark “yes” if the following statements are true for you:
The patient will receive thoracic stereotactic body radiotherapy at MD Anderson.
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Odds of Eligibility
Unknown<50%
Be sure to apply to 2-3 other trials, as you have a low likelihood of qualifying for this one.Apply To This Trial

Approximate Timelines

Please note that timelines for treatment and screening will vary by patient
Screening: ~3 weeks
Treatment: varies
Reporting: Up to 10 days
This trial has approximate timelines as follows: 3 weeks for initial screening, variable treatment timelines, and reporting: Up to 10 days.
View detailed reporting requirements
Trial Expert
Connect with the researchersHop on a 15 minute call & ask questions about:
- What options you have available- The pros & cons of this trial
- Whether you're likely to qualify- What the enrollment process looks like

Measurement Requirements

This trial is evaluating whether Continuous Positive Airway Pressure will improve 1 primary outcome and 2 secondary outcomes in patients with Cancer. Measurement will happen over the course of Up to 10 days.

Assessment of time to deliver the planned radiation dose by using the most appropriate method
UP TO 10 DAYS
The study will summarize the data with mean, standard deviation, median and range for continuous variables, and frequency count and percentage for categorical variables.
Increase in lung volume
UP TO 10 DAYS
Increase in lung volume to be determined by using DIBH or CPAP from free breathing. Linear regression may be used to evaluate the difference between CPAP and DIBH in the increase of lung volume from free breathing with the adjustment of important demographic and clinical variables in the model. The study will summarize the data with mean, standard deviation, median and range for continuous variables, and frequency count and percentage for categorical variables
Estimation of decrease in tumor motion
UP TO 10 DAYS
Paired t-test will be used to compare continuous positive airway pressure (CPAP) to deep inspiration breath hold (DIBH) in the decrease of tumor motion from free breathing. Linear regression may be used to evaluate the difference between CPAP and DIBH in the decrease of tumor motion from free breathing with the adjustment of important demographic and clinical variables in the model.

Patient Q & A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the signs of cancer?

Chronic pain and abnormal bowel movements are the most common symptoms in patients with cancer. Other signs are more rare. The symptoms appear quite differently across different types of cancer.\n

Anonymous Patient Answer

What is cancer?

Cancer is a disease in which normal cells grow and split in an uncontrolled way, resulting in new, abnormal, untidy cells that invade other parts of the body. This often causes the cells to build up in places where they have not really wanted to go – tumours, and in turn lead to metastases and death. Cancer has about 6 million new cases each year in the UK.\n

Anonymous Patient Answer

What causes cancer?

Multiple cancers have identifiable causes but most originate due to an unidentified environmental factor and are not inherited. Tobacco smoking and being overweight are the most notable environmental factors.

Anonymous Patient Answer

Can cancer be cured?

A cure is only possible if cancer is not a chronic disease. In a chronic disease like many cancer, cancer has some sort of a "trend" for its cancerous condition to grow (proliferate), that usually needs to be controlled with some sort of anticancer drug/treatment. The drug or treatment is basically aimed at eliminating the cancerous situation, but doesn't eradicate it as a whole. The drug or treatment doesn't cure cancer, it just controls it, but the drug or treatment is necessary to control cancer as a whole. Thus only if the cancer is not in a chronic, or continuous or progressive or progressing condition, that it can be cured or controlled.

Anonymous Patient Answer

What are common treatments for cancer?

The greatest number of treatments offered for cancer are surgery, chemotherapy, or radiation therapy to the same or similar degree of efficacy. Other treatments, such as CBT and homeopathy"

Anonymous Patient Answer

How many people get cancer a year in the United States?

Cancer affects a majority of the US population each year. Results from a recent clinical trial are similar to estimates from other sources. The majority of cancer cases may be preventable. More research is needed to ascertain the underlying causes of cancer and what could potentially be done to increase prevention and early detection

Anonymous Patient Answer

How does continuous positive airway pressure work?

In a recent study, findings supports and extends pre-clinical research suggesting that APAP has potential as a treatment to improve quality of life in patients with COPD and improves exercise capacity in patients with severe acute COPD exacerbations.

Anonymous Patient Answer

Has continuous positive airway pressure proven to be more effective than a placebo?

Data from a recent study CPAP was not more effective than a placebo when measured by the frequency of respiratory events or by the degree of patient satisfaction with CPAP use. This result may be explained by the heterogeneity of patients treated with CPAP. Some patients with respiratory insufficiency might benefit from CPAP, while others may not be affected by the CPAP, or may even benefit from a PAP.

Anonymous Patient Answer

Is continuous positive airway pressure typically used in combination with any other treatments?

Continuous positive airway pressure is commonly used during the acute phase of pneumonia. Patients who are receiving steroids or who require mechanical ventilation are more likely to use continuous positive airway pressure.

Anonymous Patient Answer

What is continuous positive airway pressure?

AAP is a treatment option to prevent acute exacerbation of chronic obstructive pulmonary disease (COPD) in the frail elderly. The use of AAP reduces the utilization of healthcare and the duration of hospitalization during an acute exacerbation.

Anonymous Patient Answer

How quickly does cancer spread?

Results from a recent clinical trial of this study suggest that cancer is unlikely to spread to distant parts of the body, particularly if the primary lesion is surgically removed.

Anonymous Patient Answer

Who should consider clinical trials for cancer?

Results from a recent paper indicates that in this selected group of patients, people are more likely to adhere to a course of treatment if they are informed that there is a chance of survival.

Anonymous Patient Answer
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