Suramin for Acute Kidney Injury
Trial Summary
Will I have to stop taking my current medications?
The trial information does not specify if you need to stop taking your current medications. However, if you are on warfarin, you must be on stable long-term therapy. It's best to discuss your specific medications with the trial team.
What evidence supports the effectiveness of the drug Suramin for treating acute kidney injury?
How does the drug Suramin differ from other treatments for acute kidney injury?
Suramin is unique because it can be administered after kidney injury has occurred, helping to reduce inflammation and promote kidney repair by decreasing harmful proteins and increasing cell proliferation. Unlike other treatments, it was originally developed for parasitic infections and has shown potential in reducing kidney damage and improving recovery in animal studies.678910
What is the purpose of this trial?
This trial is testing suramin, a medication, to see if it can help people with acute kidney injury (AKI) avoid worsening kidney problems. The goal is to prevent their condition from progressing to a severe stage or needing dialysis. Suramin works by blocking harmful processes that can damage the kidneys.
Eligibility Criteria
Adults with early-stage acute kidney injury (AKI) who haven't responded to a diuretic called furosemide are eligible. They must not have severe liver issues, be on multiple blood pressure medications, or have certain infections like HIV or COVID-19. A negative pregnancy test is required for women of childbearing age.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive a single 3.0 mg/kg infusion of suramin or placebo
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- Placebo
- Suramin
Find a Clinic Near You
Who Is Running the Clinical Trial?
Rediscovery Life Sciences
Lead Sponsor