Suramin for Acute Kidney Injury
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests suramin, a medication, to determine if it can prevent acute kidney injury (AKI) from worsening. The goal is to stop AKI from progressing to more severe kidney problems that might require dialysis. Participants will receive either suramin or a placebo (a harmless pill with no medication) to compare results. Suitable candidates have AKI with noticeable changes in kidney function but have not yet needed dialysis or had a kidney transplant. As a Phase 2 trial, this research measures suramin's effectiveness in an initial, smaller group, offering participants a chance to contribute to important medical advancements.
Will I have to stop taking my current medications?
The trial information does not specify if you need to stop taking your current medications. However, if you are on warfarin, you must be on stable long-term therapy. It's best to discuss your specific medications with the trial team.
Is there any evidence suggesting that suramin is likely to be safe for humans?
Research has shown that suramin has potential to protect kidneys. In one study, suramin prevented kidney damage caused by cisplatin, a drug known to harm kidneys. This suggests suramin might generally help protect kidneys.
The current study is in an early stage, typically used to assess how well people tolerate a treatment and to identify any side effects. Although suramin is being tested for acute kidney injury (AKI), it has been used previously for other health issues. Its past use suggests it might be safe, but further research is needed to confirm this.
Overall, these findings suggest suramin could be safe, but monitoring for side effects remains important as more studies are conducted.12345Why do researchers think this study treatment might be promising?
Suramin is unique because it offers a new approach to treating acute kidney injury. Most treatments for this condition focus on managing symptoms and supporting kidney function but don't directly address underlying causes. Suramin is different as it targets the root cellular stress and inflammation that contribute to kidney damage. Researchers are excited about Suramin because of its potential to reduce damage and improve recovery, which could lead to better outcomes for patients with acute kidney injury.
What evidence suggests that suramin might be an effective treatment for acute kidney injury?
Research has shown that suramin, which participants in this trial may receive, might help treat sudden kidney injury, known as acute kidney injury (AKI). Studies have found that suramin can improve kidney function after AKI caused by factors such as certain chemotherapy drugs or muscle breakdown. In these studies, suramin protected the kidneys and aided recovery by repairing kidney cells and reducing damage. This suggests that suramin could prevent AKI from worsening and requiring more serious treatments, like advanced kidney disease or dialysis. These findings offer hope that suramin could be a promising treatment for AKI.12567
Are You a Good Fit for This Trial?
Adults with early-stage acute kidney injury (AKI) who haven't responded to a diuretic called furosemide are eligible. They must not have severe liver issues, be on multiple blood pressure medications, or have certain infections like HIV or COVID-19. A negative pregnancy test is required for women of childbearing age.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive a single 3.0 mg/kg infusion of suramin or placebo
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Placebo
- Suramin
Find a Clinic Near You
Who Is Running the Clinical Trial?
Rediscovery Life Sciences
Lead Sponsor