Edecrin

induction of Diuresis, Nephrotic Syndrome, Ascites + 5 more
Treatment
6 FDA approvals
20 Active Studies for Edecrin

What is Edecrin

Etacrynic acidThe Generic name of this drug
Treatment SummaryThis drug is a diuretic that helps rid the body of excess salt and water. It works by blocking the absorption of sodium, potassium, and chloride in the kidneys, which causes more of these ions to be excreted in the urine and results in increased urinary output. This drug is known as a “loop diuretic” or “high ceiling diuretic” and is often prescribed to treat conditions such as edema and high blood pressure.
Ethacrynic Acidis the brand name
Edecrin Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Ethacrynic Acid
Etacrynic acid
1967
28

Approved as Treatment by the FDA

Etacrynic acid, otherwise called Ethacrynic Acid, is approved by the FDA for 6 uses including Swollen feet or ankles and Congenital Heart Defect .
Swollen feet or ankles
Congenital Heart Defect
Helps manage Congenital Heart Disease (CHD)
Cirrhosis
Nephrotic Syndrome
Congestive Heart Failure
Ascites
Helps manage Ascites

Effectiveness

How Edecrin Affects PatientsEthacrynic acid is a type of diuretic, which means it helps the body get rid of extra fluid. It does this by blocking sodium from being reabsorbed by the kidneys, so it can be passed out of the body. This drug is very effective in people with kidney problems, as it can help them get rid of excess fluid. Unlike other diuretics, ethacrynic acid doesn't affect how well the kidneys filter or how much blood flows to them, except when the patient has lost a lot of fluid quickly.
How Edecrin works in the bodyEthacrynic acid works as a diuretic to reduce blood pressure. It achieves this by preventing sodium, potassium, and chloride from being absorbed into the body, and instead causes them to be flushed out with urine. This leads to a decrease in plasma and extracellular fluid, which lowers both blood pressure and cardiac output. It works in a different way than carbonic anhydrase inhibitors.

When to interrupt dosage

The proposed dosage of Edecrin is reliant upon the diagnosed condition, such as Swelling, Cirrhosis and Ascites. The measure of dosage shifts with the technique of delivery (e.g. Tablet or Powder, for solution - Intravenous) featured in the table beneath.
Condition
Dosage
Administration
Congenital Heart Defect
25.0 mg, , 5.0 mg/mL, 50.0 mg
, Oral, Tablet, Tablet - Oral, Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
induction of Diuresis
25.0 mg, , 5.0 mg/mL, 50.0 mg
, Oral, Tablet, Tablet - Oral, Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Nephrotic Syndrome
25.0 mg, , 5.0 mg/mL, 50.0 mg
, Oral, Tablet, Tablet - Oral, Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Ascites
25.0 mg, , 5.0 mg/mL, 50.0 mg
, Oral, Tablet, Tablet - Oral, Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Swollen feet or ankles
25.0 mg, , 5.0 mg/mL, 50.0 mg
, Oral, Tablet, Tablet - Oral, Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Diuresis
25.0 mg, , 5.0 mg/mL, 50.0 mg
, Oral, Tablet, Tablet - Oral, Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Congestive Heart Failure
25.0 mg, , 5.0 mg/mL, 50.0 mg
, Oral, Tablet, Tablet - Oral, Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Cirrhosis
25.0 mg, , 5.0 mg/mL, 50.0 mg
, Oral, Tablet, Tablet - Oral, Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous

Warnings

There are 20 known major drug interactions with Edecrin.
Common Edecrin Drug Interactions
Drug Name
Risk Level
Description
Neomycin
Major
The risk or severity of nephrotoxicity can be increased when Etacrynic acid is combined with Neomycin.
Tenofovir
Major
Etacrynic acid may increase the nephrotoxic activities of Tenofovir.
Tenofovir alafenamide
Major
Etacrynic acid may increase the nephrotoxic activities of Tenofovir alafenamide.
Tenofovir disoproxil
Major
Etacrynic acid may increase the nephrotoxic activities of Tenofovir disoproxil.
Acebutolol
Minor
The risk or severity of adverse effects can be increased when Etacrynic acid is combined with Acebutolol.
Edecrin Toxicity & Overdose RiskTaking too much of this drug can cause excessive urination, leading to loss of important minerals and salts from the body.
image of a doctor in a lab doing drug, clinical research

Edecrin Novel Uses: Which Conditions Have a Clinical Trial Featuring Edecrin?

166 active clinical trials are currently underway to assess the potential of Edecrin in treating Nephrotic Syndrome, Ascites and Cirrhosis.
Condition
Clinical Trials
Trial Phases
Ascites
10 Actively Recruiting
Phase 3, Not Applicable, Phase 1, Phase 2
Diuresis
0 Actively Recruiting
Swollen feet or ankles
42 Actively Recruiting
Phase 1, Phase 2, Phase 3, Not Applicable, Early Phase 1, Phase 4
Congenital Heart Defect
37 Actively Recruiting
Phase 2, Not Applicable, Phase 4, Phase 3, Phase 1
Nephrotic Syndrome
11 Actively Recruiting
Phase 2, Not Applicable, Phase 3
Cirrhosis
49 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Phase 4, Phase 3, Early Phase 1
induction of Diuresis
0 Actively Recruiting
Congestive Heart Failure
22 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1

Edecrin Reviews: What are patients saying about Edecrin?

5Patient Review
1/21/2009
Edecrin for Visible Water Retention
Quickly and effectively removed the fluid retention in my right leg caused by amlodipine.
4.3Patient Review
11/21/2013
Edecrin for High Blood Pressure
I have an allergy to sulfa drugs, so this is the only water pill I can take. It works well for me. When I run out and have to wait to get more, my blood pressure goes up significantly.
4Patient Review
6/25/2012
Edecrin for High Blood Pressure
I've been on this medication for two months and it's been working well so far. I'm allergic to sulfa, and was previously taking bystolic; however, I had to stop because it made me sick. Make sure to check for sulfites in everything if you're also allergic.
4Patient Review
8/3/2012
Edecrin for Visible Water Retention
I would appreciate learning more about the manufacturer of this drug, Draxis.
3.7Patient Review
3/12/2008
Edecrin for Visible Water Retention
2.7Patient Review
1/1/2018
Edecrin for Visible Water Retention
Whenever I took Edecrin, I would begin vomiting, have severe watery diarrhea, and feel weak and achy. This made it impossible for me to work. Since I'm allergic to sulfa, I don't know what my next course of action will be.
2.7Patient Review
12/29/2013
Edecrin for High Blood Pressure
I started taking this medication to help lower my blood pressure in 2013. Last November, I started vomiting frequently and realized that it was likely due to the Edecrin. Since stopping the medication, I feel great!
2.3Patient Review
7/24/2010
Edecrin for Visible Water Retention
I took this medicine because I had a severe allergic reaction to lasix. This drug does not have sulfa. However, I had severe migraines while on this medication as well as itching and developed red pimples. Did not find this drug effective in aiding in eliminating water retention. Did assist in lowering bp a little. Stopped taking several times to confirm it was this medication causing the side effects and not bystolic which I am also on
2.3Patient Review
9/20/2010
Edecrin for High Blood Pressure
I had been managing my acid reflux well before starting this medication 3 weeks ago, but since then it's been much worse.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about edecrin

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What kind of diuretic is Edecrin?

"Ethacrynic acid works as a loop diuretic in the kidney to remove certain electrolytes and extra fluid from your body in order to lower swelling."

Answered by AI

What is Edecrin used for?

"This medication is used to decrease swelling that is caused by conditions such as cancer, congestive heart failure, liver disease, and kidney disease. This effect can help improve kidney function and lessen symptoms such as trouble breathing and swelling in the ankles, feet, hands, or stomach."

Answered by AI

Is Edecrin ototoxic?

"Some patients experience permanent hearing loss as a result of taking EDECRIN, especially those also taking other ototoxic drugs. Ototoxic drugs are known to increase the potential for hearing loss (see Drug Interactions in the precautions section)."

Answered by AI

Is Edecrin a loop diuretic?

"Edecrin is a loop diuretic used to treat fluid retention in people with congestive heart failure, liver disease, or a kidney disorder such as nephrotic syndrome."

Answered by AI

Clinical Trials for Edecrin

Have you considered Edecrin clinical trials? We made a collection of clinical trials featuring Edecrin, we think they might fit your search criteria.
Have you considered Edecrin clinical trials? We made a collection of clinical trials featuring Edecrin, we think they might fit your search criteria.
Have you considered Edecrin clinical trials? We made a collection of clinical trials featuring Edecrin, we think they might fit your search criteria.