Spaceflight for Cognitive Performance

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Johnson Space Center (JSC), Houston, TX
Cognitive Performance+1 More
Spaceflight - Other
Eligibility
Any Age
All Sexes
Eligible conditions
Select

Study Summary

This study is evaluating whether extended time in space may have negative impacts on the brain.

See full description

Eligible Conditions

  • Cognitive Performance
  • Brain Structure

Treatment Effectiveness

Effectiveness Progress

1 of 3

Other trials for Cognitive Performance

Study Objectives

This trial is evaluating whether Spaceflight will improve 6 primary outcomes and 7 secondary outcomes in patients with Cognitive Performance. Measurement will happen over the course of Change from pre-flight local task activation (investigated 60 days prior to launch) to post-flight local task activation (investigated 5 days and 30 days after return to Earth).

Day 60
Structural brain changes
Day 60
Local task activation Cognition
Local task activation Spatial Cognition
Month 12
Spatial cognition performance
Month 12
Cognitive performance
Month 12
Brain-Derived Neurotropic Factor (BDNF)
Insulin-like Growth Factor 1 (IGF-1)
Interleukin (IL)-1
Interleukin (IL)-10
Interleukin (IL)-1ra
Oxytocin
Tumor Necrosis Factor a (TNFa)
Vascular Endothelial Growth Factor (VEGF)

Trial Safety

Safety Progress

1 of 3

Other trials for Cognitive Performance

Trial Design

4 Treatment Groups

12-Month Arm
1 of 4
2-Month Arm
1 of 4
No Intervention
1 of 4
6-Month Arm
1 of 4
Experimental Treatment

This trial requires 40 total participants across 4 different treatment groups

This trial involves 4 different treatments. Spaceflight is the primary treatment being studied. Participants will be divided into 4 treatment groups. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

12-Month Arm
Other
Astronauts on 12-month International Space Station missions will be exposed to spaceflight for a duration of 12 months. Biometric and cognitive data will routinely be collected.
2-Month Arm
Other
Astronauts on 2-month International Space Station missions will be exposed to spaceflight for a duration of 2 months. Biometric and cognitive data will routinely be collected.
No Intervention
Other
Subjects matched to 12-month astronauts that stay on Earth and are investigated at similar time points.
6-Month Arm
Other
Astronauts on 6-month International Space Station missions will be exposed to spaceflight for a duration of 6 months. Biometric and cognitive data will routinely be collected.

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: change from pre-flight performance (average of tests performed 180, 120 and 60 days prior to launch) to in-flight performance (average of all tests: 1 month mission = 1 test, 2 months = 2 tests, 6 months = 6 tests, 12 months = 12 tests)
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly change from pre-flight performance (average of tests performed 180, 120 and 60 days prior to launch) to in-flight performance (average of all tests: 1 month mission = 1 test, 2 months = 2 tests, 6 months = 6 tests, 12 months = 12 tests) for reporting.

Who is running the study

Principal Investigator
M. B.
Prof. Mathias Basner,, MD PhD
University of Pennsylvania

Closest Location

Johnson Space Center (JSC) - Houston, TX

Eligibility Criteria

This trial is for patients born any sex of any age. There are 2 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
Astronauts (according to NASA requirements)
Normal, healthy volunteers (astronaut surrogates) - Astronaut surrogates will be matched for age and education relative to astronauts

Patient Q&A Section

Can brain structure be cured?

"The study reported here demonstrated that an exercise intervention for 5 weeks improved several aspects of mental fitness in patients with mild to moderate Alzheimers' disease. The study provided further evidence to support the use of exercise for the prevention of further cognitive decline in individuals with Alzheimer's disease and may be useful for individuals with other forms of dementia, including VaD." - Anonymous Online Contributor

Unverified Answer

What are the signs of brain structure?

"Structural brain abnormalities that occur with ADHD are more subtle than the neuropathologic abnormalities of psychiatric syndromes. A variety of brain abnormalities can be present; however when the abnormalities are the result of ADHD, symptoms may be more salient than anatomical ones." - Anonymous Online Contributor

Unverified Answer

What are common treatments for brain structure?

"Some common treatments for brain structure include deep brain stimulation, high-frequency rTMS therapy, and pharmacotherapy. There is not a single, definitive treatment for brain disorders. Future advances in brain surgery should await further research into individualized therapy." - Anonymous Online Contributor

Unverified Answer

What causes brain structure?

"The primary risk factor for some types of brain structure disorder is genetic; other risk factors include head injury, infections, and prenatal exposure to certain medications or substances. These cause structural damage within specific brain areas, resulting in impairments in intellectual functioning or neurological symptoms." - Anonymous Online Contributor

Unverified Answer

How many people get brain structure a year in the United States?

"Brain structure is highly prevalent in the general populace. More recent estimates suggest that the burden of brain disease is increasing. For example, the first decade of the twenty-first century was associated with a surge in the numbers being diagnosed with Alzheimer's Disease and Dementia. Further, while autism is declining, the related spectrum of neurodevelopmental disorders including PANDAS and autism spectrum disorders are on the rise. The high prevalence of neurodevelopmental disorders, as reflected in the findings of the present study, suggests that a more rigorous and integrated research on these conditions in the framework of larger, longitudinal, multidisciplinary studies of brain, neurodevelopmental and psychiatric development is required." - Anonymous Online Contributor

Unverified Answer

What is brain structure?

"brain-imaging and brain surgery techniques have increased in the past two decades, allowing physicians and neuroscientists to better define the neural mechanisms of cognition, mood, consciousness, and behavior. These techniques have given insights into the structural and functional anatomy of the brain, its diseases, and its responses to treatments. In this report, we review current trends in brain imaging and some of the most recent advances in brain surgery that have advanced our understanding of the brain and the brain-behavior relationship. We will also look at some recent advances in MR neurography and how these may have a role in defining the clinical manifestations and in guiding the treatment of neurological disorders." - Anonymous Online Contributor

Unverified Answer

What is the average age someone gets brain structure?

"Brain structure continues to form well past 20 years old. This is most apparent when looking at the cortical atrophy associated with age. The average onset of brain structure is 18 years. This age starts high for cortical atrophy, then decreases as the age increases. This knowledge may be useful when evaluating patients with brain-related complaints." - Anonymous Online Contributor

Unverified Answer

Who should consider clinical trials for brain structure?

"Many patients have symptoms of brain disease that is devastating. Clinical trials may provide new treatments to help their condition. Many physicians check to see if the patient they are treating might be eligible for a clinical trial. If you want to be tested if you can be eligible for one of these treatments, then visit Power and contact a clinical research center in your state if you think you may be a good candidate." - Anonymous Online Contributor

Unverified Answer

What does spaceflight usually treat?

"There are several known diseases aboard the International Space Station, the most common being the human spaceflight intolerance disease psychogenic intolerance. The most common and treatable condition aboard the space station would be migraines, especially the tension type. But since none of these symptoms are included as reasons for the limitations of space to treat many of these illnesses aboard the space station; there are other reasons for spaceflight limitations not yet explained. We offer suggestions to use space to treat these conditions. We also offer suggestions for treatment of the medical conditions that are treated aboard the space station." - Anonymous Online Contributor

Unverified Answer

How does spaceflight work?

"Results from a recent clinical trial suggests that spaceflight does not induce an altered microglial cellular reaction in rats. The impact of long-term microgravity stays consistent for up to 1-year and may explain the lack of microglial activation and neuropathological consequences." - Anonymous Online Contributor

Unverified Answer

What is the primary cause of brain structure?

"Since the advent of MRI, the standard interpretation of brain structure and its relationship with cognitive function is debated. This article describes the current understanding of the anatomy of the human brain, and emphasizes the relevance of considering normal variations in brain anatomy on how we interpret the structure-function relationship." - Anonymous Online Contributor

Unverified Answer

What are the common side effects of spaceflight?

"In a recent study, findings are discussed in the context of the results of several space missions investigating the physiological effects of weightlessness. In a recent study, findings are consistent with models that postulate that a decrease in metabolic demand leads to a relative'recovery' of homeostasis, which may be mediated largely by the production of circulating growth factors by the choroid plexus. This may explain the improvement in several symptoms after a space flight as well as the reduction in the long-term risk of some conditions after a space flight." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
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