This trial is evaluating whether Spaceflight will improve 6 primary outcomes and 7 secondary outcomes in patients with Cognitive Performance. Measurement will happen over the course of Change from pre-flight local task activation (investigated 60 days prior to launch) to post-flight local task activation (investigated 5 days and 30 days after return to Earth).
This trial requires 40 total participants across 4 different treatment groups
This trial involves 4 different treatments. Spaceflight is the primary treatment being studied. Participants will be divided into 4 treatment groups. There is no placebo group. The treatments being tested are not being studied for commercial purposes.
"The study reported here demonstrated that an exercise intervention for 5 weeks improved several aspects of mental fitness in patients with mild to moderate Alzheimers' disease. The study provided further evidence to support the use of exercise for the prevention of further cognitive decline in individuals with Alzheimer's disease and may be useful for individuals with other forms of dementia, including VaD." - Anonymous Online Contributor
"Structural brain abnormalities that occur with ADHD are more subtle than the neuropathologic abnormalities of psychiatric syndromes. A variety of brain abnormalities can be present; however when the abnormalities are the result of ADHD, symptoms may be more salient than anatomical ones." - Anonymous Online Contributor
"Some common treatments for brain structure include deep brain stimulation, high-frequency rTMS therapy, and pharmacotherapy. There is not a single, definitive treatment for brain disorders. Future advances in brain surgery should await further research into individualized therapy." - Anonymous Online Contributor
"The primary risk factor for some types of brain structure disorder is genetic; other risk factors include head injury, infections, and prenatal exposure to certain medications or substances. These cause structural damage within specific brain areas, resulting in impairments in intellectual functioning or neurological symptoms." - Anonymous Online Contributor
"Brain structure is highly prevalent in the general populace. More recent estimates suggest that the burden of brain disease is increasing. For example, the first decade of the twenty-first century was associated with a surge in the numbers being diagnosed with Alzheimer's Disease and Dementia. Further, while autism is declining, the related spectrum of neurodevelopmental disorders including PANDAS and autism spectrum disorders are on the rise. The high prevalence of neurodevelopmental disorders, as reflected in the findings of the present study, suggests that a more rigorous and integrated research on these conditions in the framework of larger, longitudinal, multidisciplinary studies of brain, neurodevelopmental and psychiatric development is required." - Anonymous Online Contributor
"brain-imaging and brain surgery techniques have increased in the past two decades, allowing physicians and neuroscientists to better define the neural mechanisms of cognition, mood, consciousness, and behavior. These techniques have given insights into the structural and functional anatomy of the brain, its diseases, and its responses to treatments. In this report, we review current trends in brain imaging and some of the most recent advances in brain surgery that have advanced our understanding of the brain and the brain-behavior relationship. We will also look at some recent advances in MR neurography and how these may have a role in defining the clinical manifestations and in guiding the treatment of neurological disorders." - Anonymous Online Contributor
"Brain structure continues to form well past 20 years old. This is most apparent when looking at the cortical atrophy associated with age. The average onset of brain structure is 18 years. This age starts high for cortical atrophy, then decreases as the age increases. This knowledge may be useful when evaluating patients with brain-related complaints." - Anonymous Online Contributor
"Many patients have symptoms of brain disease that is devastating. Clinical trials may provide new treatments to help their condition. Many physicians check to see if the patient they are treating might be eligible for a clinical trial. If you want to be tested if you can be eligible for one of these treatments, then visit Power and contact a clinical research center in your state if you think you may be a good candidate." - Anonymous Online Contributor
"There are several known diseases aboard the International Space Station, the most common being the human spaceflight intolerance disease psychogenic intolerance. The most common and treatable condition aboard the space station would be migraines, especially the tension type. But since none of these symptoms are included as reasons for the limitations of space to treat many of these illnesses aboard the space station; there are other reasons for spaceflight limitations not yet explained. We offer suggestions to use space to treat these conditions. We also offer suggestions for treatment of the medical conditions that are treated aboard the space station." - Anonymous Online Contributor
"Results from a recent clinical trial suggests that spaceflight does not induce an altered microglial cellular reaction in rats. The impact of long-term microgravity stays consistent for up to 1-year and may explain the lack of microglial activation and neuropathological consequences." - Anonymous Online Contributor
"Since the advent of MRI, the standard interpretation of brain structure and its relationship with cognitive function is debated. This article describes the current understanding of the anatomy of the human brain, and emphasizes the relevance of considering normal variations in brain anatomy on how we interpret the structure-function relationship." - Anonymous Online Contributor
"In a recent study, findings are discussed in the context of the results of several space missions investigating the physiological effects of weightlessness. In a recent study, findings are consistent with models that postulate that a decrease in metabolic demand leads to a relative'recovery' of homeostasis, which may be mediated largely by the production of circulating growth factors by the choroid plexus. This may explain the improvement in several symptoms after a space flight as well as the reduction in the long-term risk of some conditions after a space flight." - Anonymous Online Contributor