Phoslo

Hyperphosphataemia, Communicable Diseases, Dialysis therapy + 4 more

Treatment

3 FDA approvals

3 Active Studies for Phoslo

Treatment for

Hyperphosphataemia

What is Phoslo

Calcium acetate

The Generic name of this drug

Treatment Summary

Calcium acetate is a chemical compound consisting of calcium and acetic acid. It is more commonly known as the acetate of lime and is usually found in its hygroscopic monohydrate form.

ProcalAmine

is the brand name

image of different drug pills on a surface

Phoslo Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

ProcalAmine

Calcium acetate

1982

Approved as Treatment by the FDA

Calcium acetate, otherwise known as ProcalAmine, is approved by the FDA for 3 uses which include Kidney Failure, Chronic and End-stage Renal Failure (ESRF) .

Kidney Failure, Chronic

Helps manage End-stage Renal Failure (ESRF)

End-stage Renal Failure (ESRF)

Helps manage End-stage Renal Failure (ESRF)

Hyperphosphataemia

Helps manage Hyperphosphataemia

Effectiveness

How Phoslo Affects Patients

People with severe kidney problems may have an increased amount of phosphate in their blood, which can lead to secondary hyperparathyroidism, bone and tissue damage. To reduce the amount of phosphate, people can reduce their dietary intake and use a phosphate binder like calcium acetate. This binds to dietary phosphate in the small intestine and helps remove it from the body. Keeping the phosphate levels below 6.0 mg/dl is the goal of using calcium acetate.

How Phoslo works in the body

Calcium acetate and other calcium salts work by binding with phosphate in food, so that it can't be absorbed into the body. This helps stop excess phosphate from building up.

When to interrupt dosage

The suggested dosage of Phoslo is contingent upon the recognized affliction, for example Kidney, Hyperphosphataemia and Kidney Failure, Chronic. The portion of dosage depends upon the method of delivery (e.g. Intravenous or Topical) highlighted in the table below.

Condition

Dosage

Administration

Hyperphosphataemia

667.0 mg, , 667.0 mg/mL, 0.839 mg/mg, 0.952 mg/mg, 952.0 mg, 5.95 mg/mL, 450.0 mg, 300.0 mg, 668.0 mg, 0.26 mg/mL, 22.0 mg/mL, 6.67 mg/mg, 44.0 mg/mL

, Oral, Tablet - Oral, Tablet, Capsule - Oral, Capsule, Solution, Solution - Oral, Powder, for solution - Topical, Topical, Powder, for solution, Solution - Topical, Injection - Intravenous, Injection, Intravenous, Injection, solution, concentrate - Intravenous, Injection, solution, concentrate, Liquid, Solution - Intravenous, Liquid - Intravenous, Tablet, coated, Tablet, coated - Oral

Kidney

667.0 mg, , 667.0 mg/mL, 0.839 mg/mg, 0.952 mg/mg, 952.0 mg, 5.95 mg/mL, 450.0 mg, 300.0 mg, 668.0 mg, 0.26 mg/mL, 22.0 mg/mL, 6.67 mg/mg, 44.0 mg/mL

high phosphate levels

667.0 mg, , 667.0 mg/mL, 0.839 mg/mg, 0.952 mg/mg, 952.0 mg, 5.95 mg/mL, 450.0 mg, 300.0 mg, 668.0 mg, 0.26 mg/mL, 22.0 mg/mL, 6.67 mg/mg, 44.0 mg/mL

Astringent

667.0 mg, , 667.0 mg/mL, 0.839 mg/mg, 0.952 mg/mg, 952.0 mg, 5.95 mg/mL, 450.0 mg, 300.0 mg, 668.0 mg, 0.26 mg/mL, 22.0 mg/mL, 6.67 mg/mg, 44.0 mg/mL

Communicable Diseases

667.0 mg, , 667.0 mg/mL, 0.839 mg/mg, 0.952 mg/mg, 952.0 mg, 5.95 mg/mL, 450.0 mg, 300.0 mg, 668.0 mg, 0.26 mg/mL, 22.0 mg/mL, 6.67 mg/mg, 44.0 mg/mL

Dialysis therapy

667.0 mg, , 667.0 mg/mL, 0.839 mg/mg, 0.952 mg/mg, 952.0 mg, 5.95 mg/mL, 450.0 mg, 300.0 mg, 668.0 mg, 0.26 mg/mL, 22.0 mg/mL, 6.67 mg/mg, 44.0 mg/mL

Kidney Failure, Chronic

667.0 mg, , 667.0 mg/mL, 0.839 mg/mg, 0.952 mg/mg, 952.0 mg, 5.95 mg/mL, 450.0 mg, 300.0 mg, 668.0 mg, 0.26 mg/mL, 22.0 mg/mL, 6.67 mg/mg, 44.0 mg/mL

Warnings

Phoslo has two contraindications and should not be ingested concurrently with the conditions stated in the following table.

Phoslo Contraindications

Condition

Risk Level

Notes

Hypercalcemia

Do Not Combine

Pulse Frequency

Do Not Combine

There are 20 known major drug interactions with Phoslo.

Common Phoslo Drug Interactions

Drug Name

Risk Level

Description

Technetium Tc-99m oxidronate

Major

Calcium acetate may decrease effectiveness of Technetium Tc-99m oxidronate as a diagnostic agent.

Dobutamine

Minor

The therapeutic efficacy of Dobutamine can be decreased when used in combination with Calcium acetate.

3-Aza-2,3-Dihydrogeranyl Diphosphate

Moderate

Calcium acetate can cause a decrease in the absorption of 3-Aza-2,3-Dihydrogeranyl Diphosphate resulting in a reduced serum concentration and potentially a decrease in efficacy.

Acebutolol

Moderate

The therapeutic efficacy of Acebutolol can be decreased when used in combination with Calcium acetate.

Acetyldigitoxin

Moderate

Calcium acetate may increase the arrhythmogenic and cardiotoxic activities of Acetyldigitoxin.

Phoslo Toxicity & Overdose Risk

The lowest toxic dose of this drug in rats is 4280mg/kg. Mild effects of an overdose include constipation, loss of appetite, and nausea and vomiting. Severe overdosing can result in confusion, unconsciousness, and difficulty speaking.

Phoslo Novel Uses: Which Conditions Have a Clinical Trial Featuring Phoslo?

5 active clinical trials are investigating the potential of Phoslo to reduce phosphate levels in Kidney disorders and Hyperphosphataemia.

Condition

Clinical Trials

Trial Phases

high phosphate levels

0 Actively Recruiting

Kidney Failure, Chronic

0 Actively Recruiting

Communicable Diseases

0 Actively Recruiting

Hyperphosphataemia

0 Actively Recruiting

Dialysis therapy

3 Actively Recruiting

Not Applicable, Phase 3, Phase 4

Astringent

0 Actively Recruiting

Kidney

0 Actively Recruiting

Phoslo Reviews: What are patients saying about Phoslo?

4.7

Patient Review

6/25/2011

Phoslo for Low Amount of Calcium in the Blood

This treatment is incredibly important to me as it helps keep me from having to go through Dyalisis.

4.3

Patient Review

12/17/2011

Phoslo for High Amount of Phosphate in the Blood

This drug has been really helpful in managing my ESRD. I take it with meals and snacks, and it helps to keep my phosphorus levels lower. It's just as effective in liquid form, too, which is great.

4.3

Patient Review

9/2/2009

Phoslo for Low Amount of Calcium in the Blood

I was given this treatment in the hospital, and I'm continuing to use it today.

Patient Review

8/11/2014

Phoslo for Renal Osteodystrophy with Hyperphosphatemia

Relieved my itching significantly.

Patient Review

8/14/2013

Phoslo for High Amount of Phosphate in the Blood

I have end stage kidney failure but am not on dialysis at this time. I was taking 4 tablets a day, three times a day before meals, to get phosphorus levels down. I had blood work done after a week on the medication It worked, but raised my calcium levels to about 11.4, much higher than normal, causing an imbalance in some of my other numbers. I probably wouldn't use it again due to this single side effect.

Patient Review

4/18/2010

Phoslo for High Amount of Phosphate in the Blood

I've been a renal patient for almost three years now, and I've been on Phoslo the whole time. However, about 8 months in I started experiencing chronic diarrhea that has yet to stop. This medication has made life incredibly difficult for me.

Patient Review

4/10/2019

Phoslo for High Amount of Phosphate in the Blood

These pills can be tough to swallow and they tend to stick to your tongue and throat. Has anyone had success opening the gelcaps and sprinkling them on food?

2.7

Patient Review

4/19/2008

Phoslo for High Amount of Phosphate in the Blood

I take three pills before each meal, but my phosphate levels are still high. My doctor says I need to increase to four pills. Is there a limit on the amount you should take?

2.7

Patient Review

10/8/2009

Phoslo for High Amount of Phosphate in the Blood

I take this medication alongside renagel, but my phosphorous levels are still high. Additionally, it gives me stomach trouble and the capsules stick to my mouth, making them difficult to swallow.

2.3

Patient Review

1/31/2009

Phoslo for High Amount of Phosphate in the Blood

This medication unfortunately gives me an upset stomach.

Patient Review

4/1/2016

Phoslo for High Amount of Phosphate in the Blood

I am on the generic form of this and I try to take 6-8 per meal and 4 with snacks two with drinks. levels at record highs.

Patient Review

2/23/2008

Phoslo for High Amount of Phosphate in the Blood

Despite taking the recommended dosage, I still saw high levels when I went to dialysis. Not sure if I need to take more or if they just don't work for me, but they're too expensive to continue taking if they don't show results.

Patient Review

12/17/2008

Phoslo for High Amount of Phosphate in the Blood

The morning dosage of this can cause explosive diarrhea without much warning.

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about phoslo

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does PhosLo increase phosphorus?

"PhosLo is a drug used to treat patients with kidney failure by reducing the amount of phosphate in their blood. The dosage is increased gradually until the phosphate level in the blood falls to the desired range."

Answered by AI

Is PhosLo the same as calcium acetate?

"Calcium acetate is a phosphate binder that helps lower phosphorus levels and protect kidneys and bones. It binds to phosphate in food before it can be absorbed by the body."

Answered by AI

Why is PhosLo given with meals?

"When calcium acetate is taken with meals, it combines with phosphate in food to form calcium phosphate. However, calcium phosphate is poorly absorbed into the body and is excreted in the feces. By binding phosphate in the intestines, calcium acetate reduces absorption of phosphate into the body."

Answered by AI

What is PhosLo used for?

"Phoslo (calcium acetate) is a calcium supplement in the form of a tablet that is used to control the level of phosphate in the blood for patients who are on dialysis due to severe kidney disease."

Answered by AI