Your session is about to expire
What is Phoslo
Calcium acetateThe Generic name of this drug
Treatment SummaryCalcium acetate is a chemical compound consisting of calcium and acetic acid. It is more commonly known as the acetate of lime and is usually found in its hygroscopic monohydrate form.
ProcalAmineis the brand name
Phoslo Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
ProcalAmine
Calcium acetate
1982
77
Approved as Treatment by the FDA
Calcium acetate, otherwise known as ProcalAmine, is approved by the FDA for 3 uses which include Kidney Failure, Chronic and End-stage Renal Failure (ESRF) .Kidney Failure, Chronic
Helps manage End-stage Renal Failure (ESRF)
End-stage Renal Failure (ESRF)
Helps manage End-stage Renal Failure (ESRF)
Hyperphosphataemia
Helps manage Hyperphosphataemia
Effectiveness
How Phoslo Affects PatientsPeople with severe kidney problems may have an increased amount of phosphate in their blood, which can lead to secondary hyperparathyroidism, bone and tissue damage. To reduce the amount of phosphate, people can reduce their dietary intake and use a phosphate binder like calcium acetate. This binds to dietary phosphate in the small intestine and helps remove it from the body. Keeping the phosphate levels below 6.0 mg/dl is the goal of using calcium acetate.
How Phoslo works in the bodyCalcium acetate and other calcium salts work by binding with phosphate in food, so that it can't be absorbed into the body. This helps stop excess phosphate from building up.
When to interrupt dosage
The suggested dosage of Phoslo is contingent upon the recognized affliction, for example Kidney, Hyperphosphataemia and Kidney Failure, Chronic. The portion of dosage depends upon the method of delivery (e.g. Intravenous or Topical) highlighted in the table below.Condition
Dosage
Administration
Kidney
667.0 mg, , 667.0 mg/mL, 0.839 mg/mg, 0.952 mg/mg, 952.0 mg, 5.95 mg/mL, 450.0 mg, 300.0 mg, 668.0 mg, 0.26 mg/mL, 22.0 mg/mL, 6.67 mg/mg, 44.0 mg/mL
, Oral, Tablet - Oral, Tablet, Capsule - Oral, Capsule, Solution, Solution - Oral, Powder, for solution - Topical, Topical, Powder, for solution, Solution - Topical, Intravenous, Injection, Injection - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Liquid, Liquid - Intravenous, Solution - Intravenous, Tablet, coated, Tablet, coated - Oral
Hyperphosphataemia
667.0 mg, , 667.0 mg/mL, 0.839 mg/mg, 0.952 mg/mg, 952.0 mg, 5.95 mg/mL, 450.0 mg, 300.0 mg, 668.0 mg, 0.26 mg/mL, 22.0 mg/mL, 6.67 mg/mg, 44.0 mg/mL
, Oral, Tablet - Oral, Tablet, Capsule - Oral, Capsule, Solution, Solution - Oral, Powder, for solution - Topical, Topical, Powder, for solution, Solution - Topical, Intravenous, Injection, Injection - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Liquid, Liquid - Intravenous, Solution - Intravenous, Tablet, coated, Tablet, coated - Oral
high phosphate levels
667.0 mg, , 667.0 mg/mL, 0.839 mg/mg, 0.952 mg/mg, 952.0 mg, 5.95 mg/mL, 450.0 mg, 300.0 mg, 668.0 mg, 0.26 mg/mL, 22.0 mg/mL, 6.67 mg/mg, 44.0 mg/mL
, Oral, Tablet - Oral, Tablet, Capsule - Oral, Capsule, Solution, Solution - Oral, Powder, for solution - Topical, Topical, Powder, for solution, Solution - Topical, Intravenous, Injection, Injection - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Liquid, Liquid - Intravenous, Solution - Intravenous, Tablet, coated, Tablet, coated - Oral
Astringent
667.0 mg, , 667.0 mg/mL, 0.839 mg/mg, 0.952 mg/mg, 952.0 mg, 5.95 mg/mL, 450.0 mg, 300.0 mg, 668.0 mg, 0.26 mg/mL, 22.0 mg/mL, 6.67 mg/mg, 44.0 mg/mL
, Oral, Tablet - Oral, Tablet, Capsule - Oral, Capsule, Solution, Solution - Oral, Powder, for solution - Topical, Topical, Powder, for solution, Solution - Topical, Intravenous, Injection, Injection - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Liquid, Liquid - Intravenous, Solution - Intravenous, Tablet, coated, Tablet, coated - Oral
Communicable Diseases
667.0 mg, , 667.0 mg/mL, 0.839 mg/mg, 0.952 mg/mg, 952.0 mg, 5.95 mg/mL, 450.0 mg, 300.0 mg, 668.0 mg, 0.26 mg/mL, 22.0 mg/mL, 6.67 mg/mg, 44.0 mg/mL
, Oral, Tablet - Oral, Tablet, Capsule - Oral, Capsule, Solution, Solution - Oral, Powder, for solution - Topical, Topical, Powder, for solution, Solution - Topical, Intravenous, Injection, Injection - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Liquid, Liquid - Intravenous, Solution - Intravenous, Tablet, coated, Tablet, coated - Oral
Dialysis therapy
667.0 mg, , 667.0 mg/mL, 0.839 mg/mg, 0.952 mg/mg, 952.0 mg, 5.95 mg/mL, 450.0 mg, 300.0 mg, 668.0 mg, 0.26 mg/mL, 22.0 mg/mL, 6.67 mg/mg, 44.0 mg/mL
, Oral, Tablet - Oral, Tablet, Capsule - Oral, Capsule, Solution, Solution - Oral, Powder, for solution - Topical, Topical, Powder, for solution, Solution - Topical, Intravenous, Injection, Injection - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Liquid, Liquid - Intravenous, Solution - Intravenous, Tablet, coated, Tablet, coated - Oral
Kidney Failure, Chronic
667.0 mg, , 667.0 mg/mL, 0.839 mg/mg, 0.952 mg/mg, 952.0 mg, 5.95 mg/mL, 450.0 mg, 300.0 mg, 668.0 mg, 0.26 mg/mL, 22.0 mg/mL, 6.67 mg/mg, 44.0 mg/mL
, Oral, Tablet - Oral, Tablet, Capsule - Oral, Capsule, Solution, Solution - Oral, Powder, for solution - Topical, Topical, Powder, for solution, Solution - Topical, Intravenous, Injection, Injection - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Liquid, Liquid - Intravenous, Solution - Intravenous, Tablet, coated, Tablet, coated - Oral
Warnings
Phoslo has two contraindications and should not be ingested concurrently with the conditions stated in the following table.Phoslo ContraindicationsCondition
Risk Level
Notes
Hypercalcemia
Do Not Combine
Pulse Frequency
Do Not Combine
Common Phoslo Drug Interactions
Drug Name
Risk Level
Description
Technetium Tc-99m oxidronate
Major
Calcium acetate may decrease effectiveness of Technetium Tc-99m oxidronate as a diagnostic agent.
Dobutamine
Minor
The therapeutic efficacy of Dobutamine can be decreased when used in combination with Calcium acetate.
3-Aza-2,3-Dihydrogeranyl Diphosphate
Moderate
Calcium acetate can cause a decrease in the absorption of 3-Aza-2,3-Dihydrogeranyl Diphosphate resulting in a reduced serum concentration and potentially a decrease in efficacy.
Acebutolol
Moderate
The therapeutic efficacy of Acebutolol can be decreased when used in combination with Calcium acetate.
Acetyldigitoxin
Moderate
Calcium acetate may increase the arrhythmogenic and cardiotoxic activities of Acetyldigitoxin.
Phoslo Toxicity & Overdose RiskThe lowest toxic dose of this drug in rats is 4280mg/kg. Mild effects of an overdose include constipation, loss of appetite, and nausea and vomiting. Severe overdosing can result in confusion, unconsciousness, and difficulty speaking.
Phoslo Novel Uses: Which Conditions Have a Clinical Trial Featuring Phoslo?
5 active clinical trials are investigating the potential of Phoslo to reduce phosphate levels in Kidney disorders and Hyperphosphataemia.Condition
Clinical Trials
Trial Phases
high phosphate levels
0 Actively Recruiting
Kidney Failure, Chronic
2 Actively Recruiting
Not Applicable, Phase 1
Communicable Diseases
0 Actively Recruiting
Hyperphosphataemia
0 Actively Recruiting
Dialysis therapy
3 Actively Recruiting
Not Applicable
Astringent
0 Actively Recruiting
Kidney
0 Actively Recruiting
Phoslo Reviews: What are patients saying about Phoslo?
4.7Patient Review
6/25/2011 This treatment is incredibly important to me as it helps keep me from having to go through Dyalisis.
4.3Patient Review
12/17/2011 This drug has been really helpful in managing my ESRD. I take it with meals and snacks, and it helps to keep my phosphorus levels lower. It's just as effective in liquid form, too, which is great.
4.3Patient Review
9/2/2009 I was given this treatment in the hospital, and I'm continuing to use it today.
4Patient Review
8/11/2014 Relieved my itching significantly.
3Patient Review
8/14/2013 I have end stage kidney failure but am not on dialysis at this time. I was taking 4 tablets a day, three times a day before meals, to get phosphorus levels down. I had blood work done after a week on the medication It worked, but raised my calcium levels to about 11.4, much higher than normal, causing an imbalance in some of my other numbers. I probably wouldn't use it again due to this single side effect.
Patient Q&A Section about phoslo
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Does PhosLo increase phosphorus?
"PhosLo is a drug used to treat patients with kidney failure by reducing the amount of phosphate in their blood. The dosage is increased gradually until the phosphate level in the blood falls to the desired range."
Answered by AI
Is PhosLo the same as calcium acetate?
"Calcium acetate is a phosphate binder that helps lower phosphorus levels and protect kidneys and bones. It binds to phosphate in food before it can be absorbed by the body."
Answered by AI
Why is PhosLo given with meals?
"When calcium acetate is taken with meals, it combines with phosphate in food to form calcium phosphate. However, calcium phosphate is poorly absorbed into the body and is excreted in the feces. By binding phosphate in the intestines, calcium acetate reduces absorption of phosphate into the body."
Answered by AI
What is PhosLo used for?
"Phoslo (calcium acetate) is a calcium supplement in the form of a tablet that is used to control the level of phosphate in the blood for patients who are on dialysis due to severe kidney disease."
Answered by AI
Clinical Trials for Phoslo
Other Trials to Consider
Popular Categories
Learn More About These Treatments
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.