Phoslo

Hyperphosphataemia, Communicable Diseases, Dialysis therapy + 4 more
Treatment
3 FDA approvals
4 Active Studies for Phoslo

What is Phoslo

Calcium acetateThe Generic name of this drug
Treatment SummaryCalcium acetate is a chemical compound consisting of calcium and acetic acid. It is more commonly known as the acetate of lime and is usually found in its hygroscopic monohydrate form.
ProcalAmineis the brand name
image of different drug pills on a surface
Phoslo Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
ProcalAmine
Calcium acetate
1982
77

Approved as Treatment by the FDA

Calcium acetate, otherwise known as ProcalAmine, is approved by the FDA for 3 uses which include Kidney Failure, Chronic and End-stage Renal Failure (ESRF) .
Kidney Failure, Chronic
Helps manage End-stage Renal Failure (ESRF)
End-stage Renal Failure (ESRF)
Helps manage End-stage Renal Failure (ESRF)
Hyperphosphataemia
Helps manage Hyperphosphataemia

Effectiveness

How Phoslo Affects PatientsPeople with severe kidney problems may have an increased amount of phosphate in their blood, which can lead to secondary hyperparathyroidism, bone and tissue damage. To reduce the amount of phosphate, people can reduce their dietary intake and use a phosphate binder like calcium acetate. This binds to dietary phosphate in the small intestine and helps remove it from the body. Keeping the phosphate levels below 6.0 mg/dl is the goal of using calcium acetate.
How Phoslo works in the bodyCalcium acetate and other calcium salts work by binding with phosphate in food, so that it can't be absorbed into the body. This helps stop excess phosphate from building up.

When to interrupt dosage

The suggested dosage of Phoslo is contingent upon the recognized affliction, for example Kidney, Hyperphosphataemia and Kidney Failure, Chronic. The portion of dosage depends upon the method of delivery (e.g. Intravenous or Topical) highlighted in the table below.
Condition
Dosage
Administration
Hyperphosphataemia
667.0 mg, , 667.0 mg/mL, 0.839 mg/mg, 0.952 mg/mg, 952.0 mg, 5.95 mg/mL, 450.0 mg, 300.0 mg, 668.0 mg, 0.26 mg/mL, 22.0 mg/mL, 6.67 mg/mg, 44.0 mg/mL
, Oral, Tablet - Oral, Tablet, Capsule, Capsule - Oral, Solution, Solution - Oral, Topical, Powder, for solution - Topical, Powder, for solution, Injection, Injection - Intravenous, Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution - Intravenous, Liquid - Intravenous, Liquid, Tablet, coated - Oral, Solution - Topical, Tablet, coated
Kidney
667.0 mg, , 667.0 mg/mL, 0.839 mg/mg, 0.952 mg/mg, 952.0 mg, 5.95 mg/mL, 450.0 mg, 300.0 mg, 668.0 mg, 0.26 mg/mL, 22.0 mg/mL, 6.67 mg/mg, 44.0 mg/mL
, Oral, Tablet - Oral, Tablet, Capsule, Capsule - Oral, Solution, Solution - Oral, Topical, Powder, for solution - Topical, Powder, for solution, Injection, Injection - Intravenous, Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution - Intravenous, Liquid - Intravenous, Liquid, Tablet, coated - Oral, Solution - Topical, Tablet, coated
high phosphate levels
667.0 mg, , 667.0 mg/mL, 0.839 mg/mg, 0.952 mg/mg, 952.0 mg, 5.95 mg/mL, 450.0 mg, 300.0 mg, 668.0 mg, 0.26 mg/mL, 22.0 mg/mL, 6.67 mg/mg, 44.0 mg/mL
, Oral, Tablet - Oral, Tablet, Capsule, Capsule - Oral, Solution, Solution - Oral, Topical, Powder, for solution - Topical, Powder, for solution, Injection, Injection - Intravenous, Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution - Intravenous, Liquid - Intravenous, Liquid, Tablet, coated - Oral, Solution - Topical, Tablet, coated
Astringent
667.0 mg, , 667.0 mg/mL, 0.839 mg/mg, 0.952 mg/mg, 952.0 mg, 5.95 mg/mL, 450.0 mg, 300.0 mg, 668.0 mg, 0.26 mg/mL, 22.0 mg/mL, 6.67 mg/mg, 44.0 mg/mL
, Oral, Tablet - Oral, Tablet, Capsule, Capsule - Oral, Solution, Solution - Oral, Topical, Powder, for solution - Topical, Powder, for solution, Injection, Injection - Intravenous, Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution - Intravenous, Liquid - Intravenous, Liquid, Tablet, coated - Oral, Solution - Topical, Tablet, coated
Communicable Diseases
667.0 mg, , 667.0 mg/mL, 0.839 mg/mg, 0.952 mg/mg, 952.0 mg, 5.95 mg/mL, 450.0 mg, 300.0 mg, 668.0 mg, 0.26 mg/mL, 22.0 mg/mL, 6.67 mg/mg, 44.0 mg/mL
, Oral, Tablet - Oral, Tablet, Capsule, Capsule - Oral, Solution, Solution - Oral, Topical, Powder, for solution - Topical, Powder, for solution, Injection, Injection - Intravenous, Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution - Intravenous, Liquid - Intravenous, Liquid, Tablet, coated - Oral, Solution - Topical, Tablet, coated
Dialysis therapy
667.0 mg, , 667.0 mg/mL, 0.839 mg/mg, 0.952 mg/mg, 952.0 mg, 5.95 mg/mL, 450.0 mg, 300.0 mg, 668.0 mg, 0.26 mg/mL, 22.0 mg/mL, 6.67 mg/mg, 44.0 mg/mL
, Oral, Tablet - Oral, Tablet, Capsule, Capsule - Oral, Solution, Solution - Oral, Topical, Powder, for solution - Topical, Powder, for solution, Injection, Injection - Intravenous, Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution - Intravenous, Liquid - Intravenous, Liquid, Tablet, coated - Oral, Solution - Topical, Tablet, coated
Kidney Failure, Chronic
667.0 mg, , 667.0 mg/mL, 0.839 mg/mg, 0.952 mg/mg, 952.0 mg, 5.95 mg/mL, 450.0 mg, 300.0 mg, 668.0 mg, 0.26 mg/mL, 22.0 mg/mL, 6.67 mg/mg, 44.0 mg/mL
, Oral, Tablet - Oral, Tablet, Capsule, Capsule - Oral, Solution, Solution - Oral, Topical, Powder, for solution - Topical, Powder, for solution, Injection, Injection - Intravenous, Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution - Intravenous, Liquid - Intravenous, Liquid, Tablet, coated - Oral, Solution - Topical, Tablet, coated

Warnings

Phoslo has two contraindications and should not be ingested concurrently with the conditions stated in the following table.Phoslo Contraindications
Condition
Risk Level
Notes
Hypercalcemia
Do Not Combine
Pulse Frequency
Do Not Combine
There are 20 known major drug interactions with Phoslo.
Common Phoslo Drug Interactions
Drug Name
Risk Level
Description
Technetium Tc-99m oxidronate
Major
Calcium acetate may decrease effectiveness of Technetium Tc-99m oxidronate as a diagnostic agent.
Dobutamine
Minor
The therapeutic efficacy of Dobutamine can be decreased when used in combination with Calcium acetate.
3-Aza-2,3-Dihydrogeranyl Diphosphate
Moderate
Calcium acetate can cause a decrease in the absorption of 3-Aza-2,3-Dihydrogeranyl Diphosphate resulting in a reduced serum concentration and potentially a decrease in efficacy.
Acebutolol
Moderate
The therapeutic efficacy of Acebutolol can be decreased when used in combination with Calcium acetate.
Acetyldigitoxin
Moderate
Calcium acetate may increase the arrhythmogenic and cardiotoxic activities of Acetyldigitoxin.
Phoslo Toxicity & Overdose RiskThe lowest toxic dose of this drug in rats is 4280mg/kg. Mild effects of an overdose include constipation, loss of appetite, and nausea and vomiting. Severe overdosing can result in confusion, unconsciousness, and difficulty speaking.

Phoslo Novel Uses: Which Conditions Have a Clinical Trial Featuring Phoslo?

5 active clinical trials are investigating the potential of Phoslo to reduce phosphate levels in Kidney disorders and Hyperphosphataemia.
Condition
Clinical Trials
Trial Phases
high phosphate levels
0 Actively Recruiting
Kidney Failure, Chronic
0 Actively Recruiting
Communicable Diseases
0 Actively Recruiting
Hyperphosphataemia
0 Actively Recruiting
Dialysis therapy
4 Actively Recruiting
Not Applicable, Phase 3, Phase 4
Astringent
0 Actively Recruiting
Kidney
0 Actively Recruiting

Phoslo Reviews: What are patients saying about Phoslo?

4.7Patient Review
6/25/2011
Phoslo for Low Amount of Calcium in the Blood
This treatment is incredibly important to me as it helps keep me from having to go through Dyalisis.
4.3Patient Review
12/17/2011
Phoslo for High Amount of Phosphate in the Blood
This drug has been really helpful in managing my ESRD. I take it with meals and snacks, and it helps to keep my phosphorus levels lower. It's just as effective in liquid form, too, which is great.
4.3Patient Review
9/2/2009
Phoslo for Low Amount of Calcium in the Blood
I was given this treatment in the hospital, and I'm continuing to use it today.
4Patient Review
8/11/2014
Phoslo for Renal Osteodystrophy with Hyperphosphatemia
Relieved my itching significantly.
3Patient Review
8/14/2013
Phoslo for High Amount of Phosphate in the Blood
I have end stage kidney failure but am not on dialysis at this time. I was taking 4 tablets a day, three times a day before meals, to get phosphorus levels down. I had blood work done after a week on the medication It worked, but raised my calcium levels to about 11.4, much higher than normal, causing an imbalance in some of my other numbers. I probably wouldn't use it again due to this single side effect.
3Patient Review
4/18/2010
Phoslo for High Amount of Phosphate in the Blood
I've been a renal patient for almost three years now, and I've been on Phoslo the whole time. However, about 8 months in I started experiencing chronic diarrhea that has yet to stop. This medication has made life incredibly difficult for me.
3Patient Review
4/10/2019
Phoslo for High Amount of Phosphate in the Blood
These pills can be tough to swallow and they tend to stick to your tongue and throat. Has anyone had success opening the gelcaps and sprinkling them on food?
2.7Patient Review
4/19/2008
Phoslo for High Amount of Phosphate in the Blood
I take three pills before each meal, but my phosphate levels are still high. My doctor says I need to increase to four pills. Is there a limit on the amount you should take?
2.7Patient Review
10/8/2009
Phoslo for High Amount of Phosphate in the Blood
I take this medication alongside renagel, but my phosphorous levels are still high. Additionally, it gives me stomach trouble and the capsules stick to my mouth, making them difficult to swallow.
2.3Patient Review
1/31/2009
Phoslo for High Amount of Phosphate in the Blood
This medication unfortunately gives me an upset stomach.
2Patient Review
4/1/2016
Phoslo for High Amount of Phosphate in the Blood
I am on the generic form of this and I try to take 6-8 per meal and 4 with snacks two with drinks. levels at record highs.
2Patient Review
2/23/2008
Phoslo for High Amount of Phosphate in the Blood
Despite taking the recommended dosage, I still saw high levels when I went to dialysis. Not sure if I need to take more or if they just don't work for me, but they're too expensive to continue taking if they don't show results.
2Patient Review
12/17/2008
Phoslo for High Amount of Phosphate in the Blood
The morning dosage of this can cause explosive diarrhea without much warning.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about phoslo

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does PhosLo increase phosphorus?

"PhosLo is a drug used to treat patients with kidney failure by reducing the amount of phosphate in their blood. The dosage is increased gradually until the phosphate level in the blood falls to the desired range."

Answered by AI

Is PhosLo the same as calcium acetate?

"Calcium acetate is a phosphate binder that helps lower phosphorus levels and protect kidneys and bones. It binds to phosphate in food before it can be absorbed by the body."

Answered by AI

Why is PhosLo given with meals?

"When calcium acetate is taken with meals, it combines with phosphate in food to form calcium phosphate. However, calcium phosphate is poorly absorbed into the body and is excreted in the feces. By binding phosphate in the intestines, calcium acetate reduces absorption of phosphate into the body."

Answered by AI

What is PhosLo used for?

"Phoslo (calcium acetate) is a calcium supplement in the form of a tablet that is used to control the level of phosphate in the blood for patients who are on dialysis due to severe kidney disease."

Answered by AI

Clinical Trials for Phoslo

Image of London Health Sciences Centre in London, Canada.

Exercise for Dialysis

18 - 79
All Sexes
London, Canada
Patients receiving regular hemodialysis (HD) treatments are at a higher risk of cardiovascular events and death as HD can cause a decrease in the pumping of the heart during treatment called 'stunning'. Intradialytic exercise has emerged as a safe and effective non-drug approach to improve cardiovascular health and is now recommended for patients undergoing HD. It is currently advised that HD patients engage in at least 30 minutes of moderate to vigorous exercise three times per week. This study will evaluate the impact of exercise intensity in the HD population and determine if high impact exercise can offer better protection to the heart against HD-induced myocardial stunning.
Recruiting
Has No Placebo
London Health Sciences CentreChris McIntyre, MBBS DM
Image of Rocky Mountain Kidney Care - Lone Tree in Lone Tree, United States.

AP301 for High Phosphate Levels

Any Age
All Sexes
Lone Tree, CO
The goal of this clinical trial is to learn if AP301 could work in the patients receiving maintenance dialysis with elevated blood phosphate. The main questions it aims to answer are: * Does AP301 lower blood phosphate levels? * Does AP301 works on serum calcium level, calcium times phosphate level, and intact parathyroid hormone level? * What discomfort or medical problem do the patients have when taking AP301? * Does AP301 improve quality of life in Chinese patients? The researchers will compare AP301 to an ineffective comparator (a look-alike substance that contains low dose AP301) to see if AP301 works to treat elevated blood phosphate. In the study, the patients will experience the following stages in a chronicle order: * Stop all using blood phosphate-lowering drugs, * Take AP301 or the comparator three times a day for 8 weeks, * Take AP301 three times a day for 24 weeks, and * Take AP301 or the comparator three times a day for 3 weeks. In the first 32 weeks, the dose of AP301 will be adjusted upwards or downwards based on the patient's blood phosphate level and the study doctor's judgment. If the participant has a blood phosphate level above or below a certain level, they may receive additional treatment to lower the blood phosphate level.
Phase 3
Recruiting
Rocky Mountain Kidney Care - Lone Tree (+18 Sites)Alebund Pharmaceuticals
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