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Glutathione Peroxidase Mimetic

SPI-1005 400 mg for Noise-Induced Hearing Loss (PANIHL Trial)

Phase 2
Waitlist Available
Research Sponsored by Sound Pharmaceuticals, Incorporated
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up within 1 day
Awards & highlights

PANIHL Trial Summary

This study is evaluating whether a drug may help prevent hearing loss in individuals who have experienced hearing loss in the past.

Eligible Conditions
  • Noise-Induced Hearing Loss

PANIHL Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~within 1 day
This trial's timeline: 3 weeks for screening, Varies for treatment, and within 1 day for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Reduction in the Incidence of a Significant Threshold Shift
Secondary outcome measures
Improvement in word recognition score
Other outcome measures
Adverse events

PANIHL Trial Design

3Treatment groups
Active Control
Placebo Group
Group I: SPI-1005 400 mgActive Control1 Intervention
400 mg SPI-1005, capsule, bid, po, x7d
Group II: SPI-1005 200 mgActive Control1 Intervention
200 mg SPI-1005, capsule, bid, po, x7d
Group III: PlaceboPlacebo Group1 Intervention
0 mg SPI-1005, capsule, bid, po, x7d

Find a Location

Who is running the clinical trial?

Sound Pharmaceuticals, IncorporatedLead Sponsor
12 Previous Clinical Trials
988 Total Patients Enrolled
Jonathan Kil, MDStudy ChairSOUND PHARMACEUTICALS, INC.
5 Previous Clinical Trials
432 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
A Phase 2b Study of SPI-1005 to Prevent Acute Noise Induced Hearing Loss
2018. "A Phase 2b Study of SPI-1005 to Prevent Acute Noise Induced Hearing Loss". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02779192.
All > Noise Induced Hearing Loss > Hearing Loss
~28 spots leftby Apr 2025
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