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Procedure

Laser Disinfection for Root Canal Infections

N/A
Recruiting
Led By Bekir Karabucak, DMD, MS.
Research Sponsored by University of Pennsylvania
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up all samples will be taken during the first root canal treatment visit.sample1 before cleaning or shaping the root canal.sample2 after cleaning and shaping of the root canal using laser or naocl.sample3 upon completion of final routine irrigation protocol
Awards & highlights

Study Summary

This trial tests if a laser treatment can disinfect the canal system during endodontic treatment, to fight biofilms and compare to other antibacterial protocols.

Who is the study for?
This trial is for adults over 18 in good health with specific dental pulp diseases, who need root canal treatment. They must have a tooth that can be isolated and no history of trauma or prior endodontic work on it. Pregnant individuals or those with certain periodontal issues are excluded.Check my eligibility
What is being tested?
The study aims to develop a disinfection protocol using an FDA-approved Er,Cr:YSGG laser during routine root canal treatments. It will assess the laser's effectiveness against biofilms compared to traditional antibacterial methods like Sodium Hypochlorite.See study design
What are the potential side effects?
Potential side effects may include discomfort at the site of treatment, sensitivity in the treated tooth, and possible irritation of surrounding gum tissue due to laser application.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~all samples will be taken during the first root canal treatment visit.sample1 before cleaning or shaping the root canal.sample2 after cleaning and shaping of the root canal using laser or naocl.sample3 upon completion of final routine irrigation protocol
This trial's timeline: 3 weeks for screening, Varies for treatment, and all samples will be taken during the first root canal treatment visit.sample1 before cleaning or shaping the root canal.sample2 after cleaning and shaping of the root canal using laser or naocl.sample3 upon completion of final routine irrigation protocol for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
The change in bacterial count between the experimental group (laser) and the standard of care (NaOCl) group (routinely used irrigation protocol).
Secondary outcome measures
Mean Change from Baseline in Pain Scores at 24-hours After the Procedure on a Numeric Rating Scale (NRS)
Mean Change from Baseline in Pain Scores at 4-hours After the Procedure on a Numeric Rating Scale (NRS)
Mean Change from Baseline in Pain Scores at 48-hours After the Procedure on a Numeric Rating Scale (NRS)
+9 more

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Waterlase Express™, BIOLASE®Experimental Treatment1 Intervention
Root canals will be instrumented up to size 30/0.04 taper using Er,Cr:YSGG laser (Waterlase Express™, BIOLASE®), followed by standard of care (NaOCl).
Group II: Sodium HypochloriteActive Control1 Intervention
Root canals will be instrumented up to size 30/0.04 taper using standard of care (NaOCl).

Find a Location

Who is running the clinical trial?

University of PennsylvaniaLead Sponsor
2,005 Previous Clinical Trials
42,882,235 Total Patients Enrolled
Bekir Karabucak, DMD, MS.Principal InvestigatorChair and Professor of Endodontics. Postdoctoral Endodontics Program, Director.
Flavia Teles, DDS,MS,DMScPrincipal InvestigatorAssociate Professor, Department of Basic & Translational Sciences

Media Library

Erbium, Chromium: Yttrium, Scandium, Gallium, Garnet (Er,Cr:YSGG) Laser (Procedure) Clinical Trial Eligibility Overview. Trial Name: NCT05959629 — N/A
Root Canal Research Study Groups: Waterlase Express™, BIOLASE®, Sodium Hypochlorite
Root Canal Clinical Trial 2023: Erbium, Chromium: Yttrium, Scandium, Gallium, Garnet (Er,Cr:YSGG) Laser Highlights & Side Effects. Trial Name: NCT05959629 — N/A
Erbium, Chromium: Yttrium, Scandium, Gallium, Garnet (Er,Cr:YSGG) Laser (Procedure) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05959629 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are new participants still being admitted to this clinical trial?

"As of July 17th 2023, this clinical trial is no longer recruiting. However, there are 18 other medical studies presently enrolling participants as per information found on clinicaltrials.gov."

Answered by AI

Who else is applying?

What site did they apply to?
University of Pennsylvania, School of Dental Medicine
What portion of applicants met pre-screening criteria?
Met criteria
Recent research and studies
clinicaltrials.govStudy
Erbium, Chromium: Yttrium, Scandium, Gallium, Garnet (Er,Cr:YSGG) Laser in Root Canal Disinfection
2023. "Erbium, Chromium: Yttrium, Scandium, Gallium, Garnet (Er,Cr:YSGG) Laser in Root Canal Disinfection". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05959629.
~35 spots leftby Jul 2025
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