Lansoprazole

Zollinger-Ellison Syndrome, Curling Ulcer, maintenance of healing Erosive esophagitis + 9 more
Treatment
5 FDA approvals
5 Active Studies for Lansoprazole

What is Lansoprazole

LansoprazoleThe Generic name of this drug
Treatment SummaryDexlansoprazole is a proton pump inhibitor (PPI) used to manage symptoms of gastroesophageal reflux disease (GERD) and erosive esophagitis. It is a newer generation PPI that is released in two phases in the body, resulting in two peaks of concentrations in the blood. Dexlansoprazole works by targeting an enzyme responsible for producing stomach acid, which reduces the amount of acid in the stomach. It is generally well-tolerated and can be used for long periods of time, although it can have some adverse effects such as increased risk of bacterial infections
Prevacidis the brand name
image of different drug pills on a surface
Lansoprazole Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Prevacid
Lansoprazole
1995
326

Approved as Treatment by the FDA

Lansoprazole, otherwise known as Prevacid, is approved by the FDA for 5 uses like Duodenal Ulcer and Zollinger-Ellison Syndrome .
Duodenal Ulcer
Used to treat Duodenal Ulcer in combination with Amoxicillin
Zollinger-Ellison Syndrome
Helps manage Zollinger-Ellison Syndrome
hypersecretory conditions
Helps manage hypersecretory conditions
Helicobacter Pylori Infection
Used to treat Helicobacter Pylori Infection in combination with Amoxicillin
Curling Ulcer
Used to treat Duodenal Ulcer in combination with Amoxicillin

Effectiveness

How Lansoprazole Affects PatientsDexlansoprazole is a type of drug that reduces the amount of acid produced in the stomach. It works by blocking the enzyme (H+, K+)-ATPase, which is found on the surface of cells in the stomach lining. This prevents acid from being released.
How Lansoprazole works in the bodyDexlansoprazole works to decrease the amount of acid in your stomach. It does this by blocking an enzyme, H/K ATPase, which helps create hydrochloric acid. The drug is released into your system in two phases, first in the upper part of your small intestine, then further down. This helps the medication to be more effective. Dexlansoprazole helps reduce both regular and extra acid levels in the stomach.

When to interrupt dosage

The advised dosage of Lansoprazole is contingent upon the diagnosed condition, including healed erosive esophagitis, symptomatic non-erosive gastroesphageal reflux disease and Heartburn. The measure of dosage varies, as per the technique of administration (e.g. Capsule, delayed release or Tablet, orally disintegrating, delayed release) specified in the table beneath.
Condition
Dosage
Administration
Zollinger-Ellison Syndrome
, 15.0 mg, 30.0 mg, 30.0 mg/mL
, Kit, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Capsule; Capsule, delayed release; Kit; Tablet, Capsule; Capsule, delayed release; Kit; Tablet - Oral, Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection, Injection - Intravenous, Suspension, Suspension - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Capsule - Oral, Capsule, Kit - Oral
Curling Ulcer
, 15.0 mg, 30.0 mg, 30.0 mg/mL
, Kit, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Capsule; Capsule, delayed release; Kit; Tablet, Capsule; Capsule, delayed release; Kit; Tablet - Oral, Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection, Injection - Intravenous, Suspension, Suspension - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Capsule - Oral, Capsule, Kit - Oral
maintenance of healing Erosive esophagitis
, 15.0 mg, 30.0 mg, 30.0 mg/mL
, Kit, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Capsule; Capsule, delayed release; Kit; Tablet, Capsule; Capsule, delayed release; Kit; Tablet - Oral, Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection, Injection - Intravenous, Suspension, Suspension - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Capsule - Oral, Capsule, Kit - Oral
Duodenal Ulcer
, 15.0 mg, 30.0 mg, 30.0 mg/mL
, Kit, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Capsule; Capsule, delayed release; Kit; Tablet, Capsule; Capsule, delayed release; Kit; Tablet - Oral, Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection, Injection - Intravenous, Suspension, Suspension - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Capsule - Oral, Capsule, Kit - Oral
NSAID use
, 15.0 mg, 30.0 mg, 30.0 mg/mL
, Kit, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Capsule; Capsule, delayed release; Kit; Tablet, Capsule; Capsule, delayed release; Kit; Tablet - Oral, Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection, Injection - Intravenous, Suspension, Suspension - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Capsule - Oral, Capsule, Kit - Oral
hypersecretory conditions
, 15.0 mg, 30.0 mg, 30.0 mg/mL
, Kit, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Capsule; Capsule, delayed release; Kit; Tablet, Capsule; Capsule, delayed release; Kit; Tablet - Oral, Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection, Injection - Intravenous, Suspension, Suspension - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Capsule - Oral, Capsule, Kit - Oral
Helicobacter Pylori Infection
, 15.0 mg, 30.0 mg, 30.0 mg/mL
, Kit, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Capsule; Capsule, delayed release; Kit; Tablet, Capsule; Capsule, delayed release; Kit; Tablet - Oral, Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection, Injection - Intravenous, Suspension, Suspension - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Capsule - Oral, Capsule, Kit - Oral
Erosive Esophagitis
, 15.0 mg, 30.0 mg, 30.0 mg/mL
, Kit, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Capsule; Capsule, delayed release; Kit; Tablet, Capsule; Capsule, delayed release; Kit; Tablet - Oral, Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection, Injection - Intravenous, Suspension, Suspension - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Capsule - Oral, Capsule, Kit - Oral
Ulcer Healing
, 15.0 mg, 30.0 mg, 30.0 mg/mL
, Kit, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Capsule; Capsule, delayed release; Kit; Tablet, Capsule; Capsule, delayed release; Kit; Tablet - Oral, Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection, Injection - Intravenous, Suspension, Suspension - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Capsule - Oral, Capsule, Kit - Oral
A History of Gastric or Duodenal Ulcers
, 15.0 mg, 30.0 mg, 30.0 mg/mL
, Kit, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Capsule; Capsule, delayed release; Kit; Tablet, Capsule; Capsule, delayed release; Kit; Tablet - Oral, Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection, Injection - Intravenous, Suspension, Suspension - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Capsule - Oral, Capsule, Kit - Oral
Stomach Ulcer
, 15.0 mg, 30.0 mg, 30.0 mg/mL
, Kit, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Capsule; Capsule, delayed release; Kit; Tablet, Capsule; Capsule, delayed release; Kit; Tablet - Oral, Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection, Injection - Intravenous, Suspension, Suspension - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Capsule - Oral, Capsule, Kit - Oral
Gastroesophageal reflux disease
, 15.0 mg, 30.0 mg, 30.0 mg/mL
, Kit, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Capsule; Capsule, delayed release; Kit; Tablet, Capsule; Capsule, delayed release; Kit; Tablet - Oral, Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection, Injection - Intravenous, Suspension, Suspension - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Capsule - Oral, Capsule, Kit - Oral

Warnings

There are 20 known major drug interactions with Lansoprazole.
Common Lansoprazole Drug Interactions
Drug Name
Risk Level
Description
Albendazole
Major
The metabolism of Albendazole can be decreased when combined with Lansoprazole.
Amoxapine
Major
The metabolism of Amoxapine can be decreased when combined with Lansoprazole.
Apixaban
Major
The metabolism of Apixaban can be decreased when combined with Lansoprazole.
Artemether
Major
The metabolism of Artemether can be decreased when combined with Lansoprazole.
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Lansoprazole.
Lansoprazole Toxicity & Overdose RiskThe toxic dose of DEXILANT for mice, rats, and dogs is greater than 5,000mg/kg. Common side effects include diarrhea, abdominal pain, nausea, upper respiratory tract infection, vomiting, and gas. High blood pressure has been reported in patients taking doses of DEXILANT twice a day. Research has shown that long-term use of the drug may lead to gastric ECL cell hyperplasia and ECL cell carcinoids in rats, as well as intestinal metaplasia of the gastric epithelium. There are no known effects on fertility or the reproductive system.
image of a doctor in a lab doing drug, clinical research

Lansoprazole Novel Uses: Which Conditions Have a Clinical Trial Featuring Lansoprazole?

At present, there are 7 active trials examining the potential of Lansoprazole to alleviate Erosive Esophagitis, healed erosive esophagitis and symptomatic non-erosive gastroesphageal reflux disease.
Condition
Clinical Trials
Trial Phases
hypersecretory conditions
0 Actively Recruiting
A History of Gastric or Duodenal Ulcers
0 Actively Recruiting
Duodenal Ulcer
0 Actively Recruiting
maintenance of healing Erosive esophagitis
0 Actively Recruiting
Curling Ulcer
0 Actively Recruiting
NSAID use
0 Actively Recruiting
Ulcer Healing
1 Actively Recruiting
Not Applicable
Stomach Ulcer
0 Actively Recruiting
Helicobacter Pylori Infection
1 Actively Recruiting
Not Applicable
Zollinger-Ellison Syndrome
0 Actively Recruiting
Gastroesophageal reflux disease
0 Actively Recruiting
Erosive Esophagitis
3 Actively Recruiting
Phase 2, Phase 3

Lansoprazole Reviews: What are patients saying about Lansoprazole?

5Patient Review
5/6/2013
Lansoprazole for Condition in which Stomach Acid is Pushed Into the Esophagus
5Patient Review
8/23/2014
Lansoprazole for Conditions of Excess Stomach Acid Secretion
I was given this generic form of Prevacid 30mg and it does not work. I'm contacting my mail order pharmacy tomorrow to get something that actually works because I've been miserable since taking this pill a few days ago.
5Patient Review
3/20/2022
Lansoprazole for Medication Treatment for Healing Erosive Esophagitis
Different drugs affect different people in a variety of ways, so it's important to find the right one for you. I've tried Omeprazole and Pantoprazole but had a terrible time with them; Lansoprazole is not without its drawbacks either, but it's been overall positive for me. Some pros include that there's no reflux, I barely notice I've taken it, and I feel alright on it. However, some cons are neck pain, blocked nose, and fatigue. Overall, I would recommend this drug at 30mg in the morning and evening...but again, results may vary from person
5Patient Review
7/8/2014
Lansoprazole for Excessive Production of Stomach Acid
This treatment is effective for me.
5Patient Review
5/15/2015
Lansoprazole for Condition in which Stomach Acid is Pushed Into the Esophagus
I've been using Prevacid for over 15 years without any issues. However, with a change in insurance, Prevacid now costs me $180 for three months through Welldyn - which is an absolutely terrible company to deal with. After using lansoprazole oral for a month, I'm gassy, bloated and uncomfortable all day. Plus, the medicine is less effective than the name brand Prevacid.
View All Reviews
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Patient Q&A Section about lansoprazole

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does lansoprazole cause weight gain?

"Lansoprazole does not create weight gain on its own, however it can lead to bloating or oedema. Oedema, caused by fluid retention, can lead to an increase in body weight, making one feel tired and heavy constantly. Another possible reason for weight gain after taking lansoprazole is that acidic foods are more likely to be eaten when the acid reflux subsides."

Answered by AI

What is lansoprazole used for?

"Lansoprazole is a medication that reduces the amount of acid produced by the stomach. It is used to treat conditions such as indigestion, heartburn, acid reflux, and gastroesophageal reflux disease (GORD). Lansoprazole can also be taken to prevent and treat stomach ulcers."

Answered by AI

How long can you safely take lansoprazole?

"You should not take non-prescription lansoprazole for more than 14 days or treat yourself with it more often than once every 4 months without talking to your doctor. You should also continue to take lansoprazole even if you feel well, and not stop taking prescription lansoprazole without talking to your doctor."

Answered by AI

Is lansoprazole stronger than omeprazole?

"There is no significant difference in the clinical effectiveness of omeprazole and lansoprazole for relieving symptoms of heartburn and regurgitation. However, omeprazole is more effective than lansoprazole in increasing intragastric pH."

Answered by AI

Clinical Trials for Lansoprazole

Have you considered Lansoprazole clinical trials? We made a collection of clinical trials featuring Lansoprazole, we think they might fit your search criteria.
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