Lansoprazole

Zollinger-Ellison Syndrome, Curling Ulcer, maintenance of healing Erosive esophagitis + 9 more

Treatment

5 FDA approvals

5 Active Studies for Lansoprazole

What is Lansoprazole

Lansoprazole

The Generic name of this drug

Treatment Summary

Dexlansoprazole is a proton pump inhibitor (PPI) used to manage symptoms of gastroesophageal reflux disease (GERD) and erosive esophagitis. It is a newer generation PPI that is released in two phases in the body, resulting in two peaks of concentrations in the blood. Dexlansoprazole works by targeting an enzyme responsible for producing stomach acid, which reduces the amount of acid in the stomach. It is generally well-tolerated and can be used for long periods of time, although it can have some adverse effects such as increased risk of bacterial infections

Prevacid

is the brand name

image of different drug pills on a surface

Lansoprazole Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Prevacid

Lansoprazole

1995

326

Approved as Treatment by the FDA

Lansoprazole, otherwise known as Prevacid, is approved by the FDA for 5 uses like Duodenal Ulcer and Zollinger-Ellison Syndrome .

Duodenal Ulcer

Used to treat Duodenal Ulcer in combination with Amoxicillin

Zollinger-Ellison Syndrome

Helps manage Zollinger-Ellison Syndrome

hypersecretory conditions

Helps manage hypersecretory conditions

Helicobacter Pylori Infection

Used to treat Helicobacter Pylori Infection in combination with Amoxicillin

Curling Ulcer

Used to treat Duodenal Ulcer in combination with Amoxicillin

Effectiveness

How Lansoprazole Affects Patients

Dexlansoprazole is a type of drug that reduces the amount of acid produced in the stomach. It works by blocking the enzyme (H+, K+)-ATPase, which is found on the surface of cells in the stomach lining. This prevents acid from being released.

How Lansoprazole works in the body

Dexlansoprazole works to decrease the amount of acid in your stomach. It does this by blocking an enzyme, H/K ATPase, which helps create hydrochloric acid. The drug is released into your system in two phases, first in the upper part of your small intestine, then further down. This helps the medication to be more effective. Dexlansoprazole helps reduce both regular and extra acid levels in the stomach.

When to interrupt dosage

The advised dosage of Lansoprazole is contingent upon the diagnosed condition, including healed erosive esophagitis, symptomatic non-erosive gastroesphageal reflux disease and Heartburn. The measure of dosage varies, as per the technique of administration (e.g. Capsule, delayed release or Tablet, orally disintegrating, delayed release) specified in the table beneath.

Condition

Dosage

Administration

Zollinger-Ellison Syndrome

, 15.0 mg, 30.0 mg, 30.0 mg/mL

Kit, , Oral, Capsule, delayed release - Oral, Capsule, delayed release, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Capsule; Capsule, delayed release; Kit; Tablet - Oral, Capsule; Capsule, delayed release; Kit; Tablet, Intravenous, Injection, powder, for solution - Intravenous, Injection, powder, for solution, Injection, Injection - Intravenous, Suspension, Suspension - Oral, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating, Capsule - Oral, Kit - Oral, Capsule

Curling Ulcer

, 15.0 mg, 30.0 mg, 30.0 mg/mL

Kit, , Oral, Capsule, delayed release - Oral, Capsule, delayed release, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Capsule; Capsule, delayed release; Kit; Tablet - Oral, Capsule; Capsule, delayed release; Kit; Tablet, Intravenous, Injection, powder, for solution - Intravenous, Injection, powder, for solution, Injection, Injection - Intravenous, Suspension, Suspension - Oral, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating, Capsule - Oral, Kit - Oral, Capsule

maintenance of healing Erosive esophagitis

, 15.0 mg, 30.0 mg, 30.0 mg/mL

Kit, , Oral, Capsule, delayed release - Oral, Capsule, delayed release, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Capsule; Capsule, delayed release; Kit; Tablet - Oral, Capsule; Capsule, delayed release; Kit; Tablet, Intravenous, Injection, powder, for solution - Intravenous, Injection, powder, for solution, Injection, Injection - Intravenous, Suspension, Suspension - Oral, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating, Capsule - Oral, Kit - Oral, Capsule

Duodenal Ulcer

, 15.0 mg, 30.0 mg, 30.0 mg/mL

Kit, , Oral, Capsule, delayed release - Oral, Capsule, delayed release, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Capsule; Capsule, delayed release; Kit; Tablet - Oral, Capsule; Capsule, delayed release; Kit; Tablet, Intravenous, Injection, powder, for solution - Intravenous, Injection, powder, for solution, Injection, Injection - Intravenous, Suspension, Suspension - Oral, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating, Capsule - Oral, Kit - Oral, Capsule

NSAID use

, 15.0 mg, 30.0 mg, 30.0 mg/mL

Kit, , Oral, Capsule, delayed release - Oral, Capsule, delayed release, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Capsule; Capsule, delayed release; Kit; Tablet - Oral, Capsule; Capsule, delayed release; Kit; Tablet, Intravenous, Injection, powder, for solution - Intravenous, Injection, powder, for solution, Injection, Injection - Intravenous, Suspension, Suspension - Oral, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating, Capsule - Oral, Kit - Oral, Capsule

hypersecretory conditions

, 15.0 mg, 30.0 mg, 30.0 mg/mL

Kit, , Oral, Capsule, delayed release - Oral, Capsule, delayed release, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Capsule; Capsule, delayed release; Kit; Tablet - Oral, Capsule; Capsule, delayed release; Kit; Tablet, Intravenous, Injection, powder, for solution - Intravenous, Injection, powder, for solution, Injection, Injection - Intravenous, Suspension, Suspension - Oral, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating, Capsule - Oral, Kit - Oral, Capsule

Helicobacter Pylori Infection

, 15.0 mg, 30.0 mg, 30.0 mg/mL

Kit, , Oral, Capsule, delayed release - Oral, Capsule, delayed release, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Capsule; Capsule, delayed release; Kit; Tablet - Oral, Capsule; Capsule, delayed release; Kit; Tablet, Intravenous, Injection, powder, for solution - Intravenous, Injection, powder, for solution, Injection, Injection - Intravenous, Suspension, Suspension - Oral, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating, Capsule - Oral, Kit - Oral, Capsule

Erosive Esophagitis

, 15.0 mg, 30.0 mg, 30.0 mg/mL

Kit, , Oral, Capsule, delayed release - Oral, Capsule, delayed release, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Capsule; Capsule, delayed release; Kit; Tablet - Oral, Capsule; Capsule, delayed release; Kit; Tablet, Intravenous, Injection, powder, for solution - Intravenous, Injection, powder, for solution, Injection, Injection - Intravenous, Suspension, Suspension - Oral, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating, Capsule - Oral, Kit - Oral, Capsule

Ulcer Healing

, 15.0 mg, 30.0 mg, 30.0 mg/mL

Kit, , Oral, Capsule, delayed release - Oral, Capsule, delayed release, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Capsule; Capsule, delayed release; Kit; Tablet - Oral, Capsule; Capsule, delayed release; Kit; Tablet, Intravenous, Injection, powder, for solution - Intravenous, Injection, powder, for solution, Injection, Injection - Intravenous, Suspension, Suspension - Oral, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating, Capsule - Oral, Kit - Oral, Capsule

A History of Gastric or Duodenal Ulcers

, 15.0 mg, 30.0 mg, 30.0 mg/mL

Kit, , Oral, Capsule, delayed release - Oral, Capsule, delayed release, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Capsule; Capsule, delayed release; Kit; Tablet - Oral, Capsule; Capsule, delayed release; Kit; Tablet, Intravenous, Injection, powder, for solution - Intravenous, Injection, powder, for solution, Injection, Injection - Intravenous, Suspension, Suspension - Oral, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating, Capsule - Oral, Kit - Oral, Capsule

Stomach Ulcer

, 15.0 mg, 30.0 mg, 30.0 mg/mL

Kit, , Oral, Capsule, delayed release - Oral, Capsule, delayed release, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Capsule; Capsule, delayed release; Kit; Tablet - Oral, Capsule; Capsule, delayed release; Kit; Tablet, Intravenous, Injection, powder, for solution - Intravenous, Injection, powder, for solution, Injection, Injection - Intravenous, Suspension, Suspension - Oral, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating, Capsule - Oral, Kit - Oral, Capsule

Gastroesophageal reflux disease

, 15.0 mg, 30.0 mg, 30.0 mg/mL

Kit, , Oral, Capsule, delayed release - Oral, Capsule, delayed release, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Capsule; Capsule, delayed release; Kit; Tablet - Oral, Capsule; Capsule, delayed release; Kit; Tablet, Intravenous, Injection, powder, for solution - Intravenous, Injection, powder, for solution, Injection, Injection - Intravenous, Suspension, Suspension - Oral, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating, Capsule - Oral, Kit - Oral, Capsule

Warnings

There are 20 known major drug interactions with Lansoprazole.

Common Lansoprazole Drug Interactions

Drug Name

Risk Level

Description

Albendazole

Major

The metabolism of Albendazole can be decreased when combined with Lansoprazole.

Amoxapine

Major

The metabolism of Amoxapine can be decreased when combined with Lansoprazole.

Apixaban

Major

The metabolism of Apixaban can be decreased when combined with Lansoprazole.

Artemether

Major

The metabolism of Artemether can be decreased when combined with Lansoprazole.

Astemizole

Major

The metabolism of Astemizole can be decreased when combined with Lansoprazole.

Lansoprazole Toxicity & Overdose Risk

The toxic dose of DEXILANT for mice, rats, and dogs is greater than 5,000mg/kg. Common side effects include diarrhea, abdominal pain, nausea, upper respiratory tract infection, vomiting, and gas. High blood pressure has been reported in patients taking doses of DEXILANT twice a day. Research has shown that long-term use of the drug may lead to gastric ECL cell hyperplasia and ECL cell carcinoids in rats, as well as intestinal metaplasia of the gastric epithelium. There are no known effects on fertility or the reproductive system.

image of a doctor in a lab doing drug, clinical research

Lansoprazole Novel Uses: Which Conditions Have a Clinical Trial Featuring Lansoprazole?

At present, there are 7 active trials examining the potential of Lansoprazole to alleviate Erosive Esophagitis, healed erosive esophagitis and symptomatic non-erosive gastroesphageal reflux disease.

Condition

Clinical Trials

Trial Phases

hypersecretory conditions

0 Actively Recruiting

A History of Gastric or Duodenal Ulcers

0 Actively Recruiting

Duodenal Ulcer

0 Actively Recruiting

maintenance of healing Erosive esophagitis

0 Actively Recruiting

Curling Ulcer

0 Actively Recruiting

NSAID use

0 Actively Recruiting

Ulcer Healing

1 Actively Recruiting

Not Applicable

Stomach Ulcer

0 Actively Recruiting

Helicobacter Pylori Infection

2 Actively Recruiting

Not Applicable, Phase 4

Zollinger-Ellison Syndrome

0 Actively Recruiting

Gastroesophageal reflux disease

0 Actively Recruiting

Erosive Esophagitis

2 Actively Recruiting

Phase 2, Phase 3

Lansoprazole Reviews: What are patients saying about Lansoprazole?

5

Patient Review

5/6/2013

Lansoprazole for Condition in which Stomach Acid is Pushed Into the Esophagus

5

Patient Review

8/23/2014

Lansoprazole for Conditions of Excess Stomach Acid Secretion

I was given this generic form of Prevacid 30mg and it does not work. I'm contacting my mail order pharmacy tomorrow to get something that actually works because I've been miserable since taking this pill a few days ago.

5

Patient Review

3/20/2022

Lansoprazole for Medication Treatment for Healing Erosive Esophagitis

Different drugs affect different people in a variety of ways, so it's important to find the right one for you. I've tried Omeprazole and Pantoprazole but had a terrible time with them; Lansoprazole is not without its drawbacks either, but it's been overall positive for me. Some pros include that there's no reflux, I barely notice I've taken it, and I feel alright on it. However, some cons are neck pain, blocked nose, and fatigue. Overall, I would recommend this drug at 30mg in the morning and evening...but again, results may vary from person

5

Patient Review

7/8/2014

Lansoprazole for Excessive Production of Stomach Acid

This treatment is effective for me.

5

Patient Review

5/15/2015

Lansoprazole for Condition in which Stomach Acid is Pushed Into the Esophagus

I've been using Prevacid for over 15 years without any issues. However, with a change in insurance, Prevacid now costs me $180 for three months through Welldyn - which is an absolutely terrible company to deal with. After using lansoprazole oral for a month, I'm gassy, bloated and uncomfortable all day. Plus, the medicine is less effective than the name brand Prevacid.

5

Patient Review

5/14/2022

Lansoprazole for Increased Stomach Acid from Systemic Mastocytosis

I can't overstate how thankful I am for this treatment. It has quite literally changed my life for the better. Before, even simple things like drinking a glass of water would send me into fits of pain. Now, I can eat and drink normally without any issues whatsoever.

4.7

Patient Review

9/17/2014

Lansoprazole for Condition in which Stomach Acid is Pushed Into the Esophagus

I had great results with Prevacid, but ever since I switched to the generic version by Mylan, I've been having a lot more trouble with acid reflux.

3.3

Patient Review

10/31/2013

Lansoprazole for Condition in which Stomach Acid is Pushed Into the Esophagus

3.3

Patient Review

12/16/2016

Lansoprazole for Condition in which Stomach Acid is Pushed Into the Esophagus

This medication cured my severe acid reflux, but unfortunately I started having very severe diarrhea within two weeks of use. This happened up to five times a day, and my GP insisted that it wasn't the medication. They tested me for Crohn's Disease and gluten allergies, but everything came back negative. Eventually I stopped taking the medication and the diarrhea stopped. Now I'm on Pantoprazole with no problems three months in.

3

Patient Review

9/30/2017

Lansoprazole for Condition in which Stomach Acid is Pushed Into the Esophagus

I found this treatment effective for a short period of time, but then my acid reflux returned even worse than before. Not sure why this is the case.

2.7

Patient Review

5/26/2021

Lansoprazole for Indigestion

My doctor is still trying to figure out what's causing my indigestion, belching, nausea, and loose bowels. I'm currently taking Lansoprazole twice a day, which has helped a little bit with the indigestion. However, now it's causing severe nausea and diarrhea. The benefits don't seem worth the side effects.

2.3

Patient Review

12/29/2013

Lansoprazole for Condition in which Stomach Acid is Pushed Into the Esophagus

I wasn't thrilled when my doctor switched me from dexilant to this medication.

2

Patient Review

4/19/2013

Lansoprazole for Heartburn

2

Patient Review

1/1/2015

Lansoprazole for Condition in which Stomach Acid is Pushed Into the Esophagus

My acid reflux has decreased since I started taking this medication, in combination with ranitidine at bedtime.

1

Patient Review

5/30/2015

Lansoprazole for Heartburn

I've been taking this medication for three years now, and it's done wonders for my Barrett's esophagus. I only have the occasional episode of reflux now, whereas before I was constantly in pain and unable to eat many foods. There are some side effects like impact on regularity and stool consistency, but overall I'm very pleased with the benefits of this treatment.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about lansoprazole

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does lansoprazole cause weight gain?

"Lansoprazole does not create weight gain on its own, however it can lead to bloating or oedema. Oedema, caused by fluid retention, can lead to an increase in body weight, making one feel tired and heavy constantly. Another possible reason for weight gain after taking lansoprazole is that acidic foods are more likely to be eaten when the acid reflux subsides."

Answered by AI

What is lansoprazole used for?

"Lansoprazole is a medication that reduces the amount of acid produced by the stomach. It is used to treat conditions such as indigestion, heartburn, acid reflux, and gastroesophageal reflux disease (GORD). Lansoprazole can also be taken to prevent and treat stomach ulcers."

Answered by AI

How long can you safely take lansoprazole?

"You should not take non-prescription lansoprazole for more than 14 days or treat yourself with it more often than once every 4 months without talking to your doctor. You should also continue to take lansoprazole even if you feel well, and not stop taking prescription lansoprazole without talking to your doctor."

Answered by AI

Is lansoprazole stronger than omeprazole?

"There is no significant difference in the clinical effectiveness of omeprazole and lansoprazole for relieving symptoms of heartburn and regurgitation. However, omeprazole is more effective than lansoprazole in increasing intragastric pH."

Answered by AI

Clinical Trials for Lansoprazole

Image of Brigham and Women's Hospital in Boston, United States.

Argon Plasma for Helicobacter Pylori Infection

18+
All Sexes
Boston, MA

The objective of the study is to investigate the efficacy and safety of an argon plasma-based therapy - HEAPE - in treating H. pylori infections during endoscopic procedures. By filling the stomach with sodium chloride solution that is treated with APC (PAL), the Investigators hypothesize a significant reduction in H. pylori. The use of PAL instead of direct application of APC allows for a broader and more homogeneous application throughout the stomach and a faster procedure time, as the fluid bypasses the thermal effects typically associated with higher electrical power settings and focuses on the bactericidal action of PAL. It is a procedure that does not involve thermal ablation of the stomach lining. Thus, side effects should be expected to be as low as possible. Two different PAL generation modalities will be compared in this study: 1. HEAPE direct: This modality is the direct generation of PAL in the stomach. The stomach is filled with sodium chloride solution which is then treated with APC. With HEAPE direct a potential decrease of reactive species is avoided, as the treatment happens directly at the intended location in the H. pylori infected stomach. 2. Pre-HEAPE: This modality features the treatment of sodium chloride with APC outside of the patient in a sterile container. After the APC treatment, the generated PAL is administered into the stomach with a syringe through the working channel of the endoscope. Pre-HEAPE allows an easier handling of the APC probe as the treatment of the sodium chloride solution can be done without an endoscope. To evaluate the immediate effect of this novel treatment approach the metabolic activity of H. pylori will be assessed using a urea breath test (UBT) before and after treatment. A reduction in H. pylori levels can be detected by a reduction in urease activity in the breath test. After the HEAPE procedure, patients are treated with antibiotics (best practice) as they would be under normal circumstances. Four weeks after treatment, another UBT is performed to determine if H. pylori has been eradicated or if additional antibiotic treatment is indicated. This two-arm, randomized, pilot, single-center, prospective clinical study is designed to evaluate the safety, tolerability and proof of concept that PAL has the ability to eradicate or reduce the bacterial load of H. pylori in humans.

Recruiting
Has No Placebo

Brigham and Women's Hospital

Christopher C Thompson, MD

Erbe Elektromedizin GmbH

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