Prevacid

Zollinger-Ellison Syndrome, Curling Ulcer, maintenance of healing Erosive esophagitis + 9 more

Treatment

5 FDA approvals

5 Active Studies for Prevacid

What is Prevacid

Lansoprazole

The Generic name of this drug

Treatment Summary

Lansoprazole, sold under the brand name Prevacid, is a medication used to reduce stomach acid production. It works by targeting enzymes that cause acid secretion and is used to treat ulcers, GERD, and other conditions caused by too much stomach acid. It is classified as a type of benzimidazole and is one of the most commonly prescribed proton pump inhibitors.

Prevacid

is the brand name

image of different drug pills on a surface

Prevacid Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Prevacid

Lansoprazole

1995

326

Approved as Treatment by the FDA

Lansoprazole, otherwise known as Prevacid, is approved by the FDA for 5 uses like Duodenal Ulcer and Zollinger-Ellison Syndrome .

Duodenal Ulcer

Used to treat Duodenal Ulcer in combination with Amoxicillin

Zollinger-Ellison Syndrome

Helps manage Zollinger-Ellison Syndrome

hypersecretory conditions

Helps manage hypersecretory conditions

Helicobacter Pylori Infection

Used to treat Helicobacter Pylori Infection in combination with Amoxicillin

Curling Ulcer

Used to treat Duodenal Ulcer in combination with Amoxicillin

Effectiveness

How Prevacid Affects Patients

Lansoprazole helps to reduce stomach acid by blocking an enzyme (H+,K+-ATPase) in the cells that produce acid. This drug can be taken at any time of day and is typically effective in healing duodenal ulcers, reducing ulcer-related pain, and providing relief from heartburn symptoms. It also reduces the production of pepsin, making it a suitable treatment option for conditions like Zollinger-Ellison syndrome that cause too much acid production.

How Prevacid works in the body

Lansoprazole is a proton pump inhibitor (PPI) that stops your stomach from producing too much acid. It works by becoming activated in an acidic environment, then binding to two cysteine molecules in the proton pump of your stomach. This binding is strong and long-lasting, so it can provide long-term inhibition of acid production.

When to interrupt dosage

The prescribed dosage of Prevacid is contingent upon the diagnosed state, including A History of Gastric or Duodenal Ulcers, Stomach Ulcer and Erosive Esophagitis. The measure of dosage can be located in the following table, in accordance with the method of administration.

Condition

Dosage

Administration

Zollinger-Ellison Syndrome

, 15.0 mg, 30.0 mg, 30.0 mg/mL

Kit, , Oral, Capsule, delayed release - Oral, Capsule, delayed release, Tablet, orally disintegrating, delayed release, Capsule, delayed release pellets - Oral, Tablet, orally disintegrating, delayed release - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Capsule; Capsule, delayed release; Kit; Tablet - Oral, Capsule; Capsule, delayed release; Kit; Tablet, Intravenous, Injection, powder, for solution - Intravenous, Injection, Injection - Intravenous, Suspension, Suspension - Oral, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating, Capsule - Oral, Capsule, Capsule, delayed release pellets, Injection, powder, for solution, Kit - Oral

Curling Ulcer

, 15.0 mg, 30.0 mg, 30.0 mg/mL

Kit, , Oral, Capsule, delayed release - Oral, Capsule, delayed release, Tablet, orally disintegrating, delayed release, Capsule, delayed release pellets - Oral, Tablet, orally disintegrating, delayed release - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Capsule; Capsule, delayed release; Kit; Tablet - Oral, Capsule; Capsule, delayed release; Kit; Tablet, Intravenous, Injection, powder, for solution - Intravenous, Injection, Injection - Intravenous, Suspension, Suspension - Oral, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating, Capsule - Oral, Capsule, Capsule, delayed release pellets, Injection, powder, for solution, Kit - Oral

maintenance of healing Erosive esophagitis

, 15.0 mg, 30.0 mg, 30.0 mg/mL

Kit, , Oral, Capsule, delayed release - Oral, Capsule, delayed release, Tablet, orally disintegrating, delayed release, Capsule, delayed release pellets - Oral, Tablet, orally disintegrating, delayed release - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Capsule; Capsule, delayed release; Kit; Tablet - Oral, Capsule; Capsule, delayed release; Kit; Tablet, Intravenous, Injection, powder, for solution - Intravenous, Injection, Injection - Intravenous, Suspension, Suspension - Oral, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating, Capsule - Oral, Capsule, Capsule, delayed release pellets, Injection, powder, for solution, Kit - Oral

Duodenal Ulcer

, 15.0 mg, 30.0 mg, 30.0 mg/mL

Kit, , Oral, Capsule, delayed release - Oral, Capsule, delayed release, Tablet, orally disintegrating, delayed release, Capsule, delayed release pellets - Oral, Tablet, orally disintegrating, delayed release - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Capsule; Capsule, delayed release; Kit; Tablet - Oral, Capsule; Capsule, delayed release; Kit; Tablet, Intravenous, Injection, powder, for solution - Intravenous, Injection, Injection - Intravenous, Suspension, Suspension - Oral, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating, Capsule - Oral, Capsule, Capsule, delayed release pellets, Injection, powder, for solution, Kit - Oral

NSAID use

, 15.0 mg, 30.0 mg, 30.0 mg/mL

Kit, , Oral, Capsule, delayed release - Oral, Capsule, delayed release, Tablet, orally disintegrating, delayed release, Capsule, delayed release pellets - Oral, Tablet, orally disintegrating, delayed release - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Capsule; Capsule, delayed release; Kit; Tablet - Oral, Capsule; Capsule, delayed release; Kit; Tablet, Intravenous, Injection, powder, for solution - Intravenous, Injection, Injection - Intravenous, Suspension, Suspension - Oral, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating, Capsule - Oral, Capsule, Capsule, delayed release pellets, Injection, powder, for solution, Kit - Oral

hypersecretory conditions

, 15.0 mg, 30.0 mg, 30.0 mg/mL

Kit, , Oral, Capsule, delayed release - Oral, Capsule, delayed release, Tablet, orally disintegrating, delayed release, Capsule, delayed release pellets - Oral, Tablet, orally disintegrating, delayed release - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Capsule; Capsule, delayed release; Kit; Tablet - Oral, Capsule; Capsule, delayed release; Kit; Tablet, Intravenous, Injection, powder, for solution - Intravenous, Injection, Injection - Intravenous, Suspension, Suspension - Oral, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating, Capsule - Oral, Capsule, Capsule, delayed release pellets, Injection, powder, for solution, Kit - Oral

Helicobacter Pylori Infection

, 15.0 mg, 30.0 mg, 30.0 mg/mL

Kit, , Oral, Capsule, delayed release - Oral, Capsule, delayed release, Tablet, orally disintegrating, delayed release, Capsule, delayed release pellets - Oral, Tablet, orally disintegrating, delayed release - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Capsule; Capsule, delayed release; Kit; Tablet - Oral, Capsule; Capsule, delayed release; Kit; Tablet, Intravenous, Injection, powder, for solution - Intravenous, Injection, Injection - Intravenous, Suspension, Suspension - Oral, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating, Capsule - Oral, Capsule, Capsule, delayed release pellets, Injection, powder, for solution, Kit - Oral

Erosive Esophagitis

, 15.0 mg, 30.0 mg, 30.0 mg/mL

Kit, , Oral, Capsule, delayed release - Oral, Capsule, delayed release, Tablet, orally disintegrating, delayed release, Capsule, delayed release pellets - Oral, Tablet, orally disintegrating, delayed release - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Capsule; Capsule, delayed release; Kit; Tablet - Oral, Capsule; Capsule, delayed release; Kit; Tablet, Intravenous, Injection, powder, for solution - Intravenous, Injection, Injection - Intravenous, Suspension, Suspension - Oral, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating, Capsule - Oral, Capsule, Capsule, delayed release pellets, Injection, powder, for solution, Kit - Oral

Ulcer Healing

, 15.0 mg, 30.0 mg, 30.0 mg/mL

Kit, , Oral, Capsule, delayed release - Oral, Capsule, delayed release, Tablet, orally disintegrating, delayed release, Capsule, delayed release pellets - Oral, Tablet, orally disintegrating, delayed release - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Capsule; Capsule, delayed release; Kit; Tablet - Oral, Capsule; Capsule, delayed release; Kit; Tablet, Intravenous, Injection, powder, for solution - Intravenous, Injection, Injection - Intravenous, Suspension, Suspension - Oral, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating, Capsule - Oral, Capsule, Capsule, delayed release pellets, Injection, powder, for solution, Kit - Oral

A History of Gastric or Duodenal Ulcers

, 15.0 mg, 30.0 mg, 30.0 mg/mL

Kit, , Oral, Capsule, delayed release - Oral, Capsule, delayed release, Tablet, orally disintegrating, delayed release, Capsule, delayed release pellets - Oral, Tablet, orally disintegrating, delayed release - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Capsule; Capsule, delayed release; Kit; Tablet - Oral, Capsule; Capsule, delayed release; Kit; Tablet, Intravenous, Injection, powder, for solution - Intravenous, Injection, Injection - Intravenous, Suspension, Suspension - Oral, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating, Capsule - Oral, Capsule, Capsule, delayed release pellets, Injection, powder, for solution, Kit - Oral

Stomach Ulcer

, 15.0 mg, 30.0 mg, 30.0 mg/mL

Kit, , Oral, Capsule, delayed release - Oral, Capsule, delayed release, Tablet, orally disintegrating, delayed release, Capsule, delayed release pellets - Oral, Tablet, orally disintegrating, delayed release - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Capsule; Capsule, delayed release; Kit; Tablet - Oral, Capsule; Capsule, delayed release; Kit; Tablet, Intravenous, Injection, powder, for solution - Intravenous, Injection, Injection - Intravenous, Suspension, Suspension - Oral, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating, Capsule - Oral, Capsule, Capsule, delayed release pellets, Injection, powder, for solution, Kit - Oral

Gastroesophageal reflux disease

, 15.0 mg, 30.0 mg, 30.0 mg/mL

Kit, , Oral, Capsule, delayed release - Oral, Capsule, delayed release, Tablet, orally disintegrating, delayed release, Capsule, delayed release pellets - Oral, Tablet, orally disintegrating, delayed release - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Capsule; Capsule, delayed release; Kit; Tablet - Oral, Capsule; Capsule, delayed release; Kit; Tablet, Intravenous, Injection, powder, for solution - Intravenous, Injection, Injection - Intravenous, Suspension, Suspension - Oral, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating, Capsule - Oral, Capsule, Capsule, delayed release pellets, Injection, powder, for solution, Kit - Oral

Warnings

There are 20 known major drug interactions with Prevacid.

Common Prevacid Drug Interactions

Drug Name

Risk Level

Description

Albendazole

Major

The metabolism of Albendazole can be decreased when combined with Lansoprazole.

Amoxapine

Major

The metabolism of Amoxapine can be decreased when combined with Lansoprazole.

Apixaban

Major

The metabolism of Apixaban can be decreased when combined with Lansoprazole.

Artemether

Major

The metabolism of Artemether can be decreased when combined with Lansoprazole.

Astemizole

Major

The metabolism of Astemizole can be decreased when combined with Lansoprazole.

Prevacid Toxicity & Overdose Risk

Lansoprazole is generally well tolerated, but may cause abdominal pain, constipation, diarrhea, or nausea in some patients. There have been reports of a serious skin reaction called toxic epidermal necrolysis (TEN), though this is rare. In one case, a patient took a very high dose of 600mg of lansoprazole with no side effects. Lansoprazole is categorized as pregnancy category B, meaning there is some animal data that suggests it is safe for use in pregnant women, but more data is needed. It is unknown if lansoprazole is passed through breastmilk,

image of a doctor in a lab doing drug, clinical research

Prevacid Novel Uses: Which Conditions Have a Clinical Trial Featuring Prevacid?

There are 4 active clinical trials evaluating the potential of Prevacid to treat Gastric Ulcer, NSAID-Induced Gastric Ulcers and a History of Gastric or Duodenal Ulcers.

Condition

Clinical Trials

Trial Phases

hypersecretory conditions

0 Actively Recruiting

A History of Gastric or Duodenal Ulcers

0 Actively Recruiting

Duodenal Ulcer

0 Actively Recruiting

maintenance of healing Erosive esophagitis

0 Actively Recruiting

Curling Ulcer

0 Actively Recruiting

NSAID use

0 Actively Recruiting

Ulcer Healing

1 Actively Recruiting

Not Applicable

Stomach Ulcer

0 Actively Recruiting

Helicobacter Pylori Infection

2 Actively Recruiting

Not Applicable, Phase 4

Zollinger-Ellison Syndrome

0 Actively Recruiting

Gastroesophageal reflux disease

0 Actively Recruiting

Erosive Esophagitis

2 Actively Recruiting

Phase 2, Phase 3

Prevacid Reviews: What are patients saying about Prevacid?

5

Patient Review

3/2/2013

Prevacid for Excessive Production of Stomach Acid

Prevacid saved my life. I was losing weight rapidly and thought I was dying until I was diagnosed with GERD. This medication took a while to work, but it healed the erosion in my stomach and allowed me to eat normal foods again. If you miss a dose, your symptoms will come back, but for me, this is a small price to pay for being able to live a normal life again.

5

Patient Review

10/21/2013

Prevacid for Heartburn

Prevacid has been a game-changer for me. It's the first PPI that I've tried that has actually helped alleviate some of my symptoms.

5

Patient Review

8/18/2014

Prevacid for Excessive Production of Stomach Acid

Unfortunately, this treatment didn't work for me. I developed blisters and hives within a week of starting it.

4.7

Patient Review

5/2/2013

Prevacid for Condition in which Stomach Acid is Pushed Into the Esophagus

Worked well for three days, but then I started having some uncomfortable side effects like itching and coughing. Had to stop taking it after that.

4.3

Patient Review

3/22/2019

Prevacid for Heartburn

This drug works well for me, though I do get mild nausea throughout the day. However, I think it's a great value considering how expensive other medications like this are.

4.3

Patient Review

5/31/2014

Prevacid for Excessive Production of Stomach Acid

The medication was effective for a few weeks, but then I developed a rash. Even after discontinuing use, the rash spread all over my body.

4

Patient Review

5/13/2013

Prevacid for Condition in which Stomach Acid is Pushed Into the Esophagus

I was having heartburn after eating, which continued even after I got over the flu. This product worked immediately on the first day, and I haven't had any issues with heartburn for two weeks now.

4

Patient Review

1/30/2013

Prevacid for Condition in which Stomach Acid is Pushed Into the Esophagus

I now have a constant, persistent cough.

3.7

Patient Review

3/29/2014

Prevacid for Heartburn

I had severe stomach pain that was so bad I missed two days of work. It was a horrible pain that kept me awake for two nights. Other than that, it did a great job getting rid of my acid reflux.

3.7

Patient Review

11/2/2013

Prevacid for Inflammation of the Esophagus with Erosion

This treatment has not been effective in helping me sleep.

2

Patient Review

8/20/2013

Prevacid for Condition in which Stomach Acid is Pushed Into the Esophagus

I unfortunately felt increased muscle and joint pain, fatigue, and dizziness after taking this medication.

1.7

Patient Review

11/18/2013

Prevacid for Heartburn

While this drug was effective for my condition, the muscle aches it caused were unbearable. I was taking a larger dose than recommended and experienced cramping after just one month. Unfortunately, I had to stop taking the medication.

1.7

Patient Review

1/10/2013

Prevacid for Excessive Production of Stomach Acid

1.7

Patient Review

1/1/2021

Prevacid for Medication Treatment for Healing Erosive Esophagitis

I experienced severe abdominal pain, nausea, drowsiness, and diarrhea.

1

Patient Review

8/11/2014

Prevacid for Condition in which Stomach Acid is Pushed Into the Esophagus

This medication is pretty effective at reducing heartburn. I've been using it for seven years now with occasional stomach aches and diarrhea as the only side effects.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about prevacid

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the difference between Pepcid and Prevacid?

"Pepcid can also help with heartburn, gastroesophageal reflux disease (GERD), and Zollinger-Ellison syndrome. Pepcid and Prevacid are in different categories of drugs. Pepcid is an H2-blocker and Prevacid is a proton pump inhibitor (PPI). Pepcid and Prevacid can be bought without a prescription (OTC) and come in generic form."

Answered by AI

When should you take Prevacid?

"You should take Prevacid 15-30 minutes before a meal with a cool glass of water, and you should take it at the same time each day. The peak for the medication is 0.5-3.5 hours after you take it."

Answered by AI

Is Prilosec and Prevacid the same thing?

"Prevacid and Prilosec are similar because they are in the same drug class and work in the same way, but there are some differences between them in terms of indications, cost, drug interactions, side effects, and warnings."

Answered by AI

What is Prevacid used to treat?

"This medication helps withheartburn, difficulty swallowing, and persistent cough. Additionally, it helps heal damage caused by stomach acid to the esophagus and may help prevent ulcers and cancer of the esophagus."

Answered by AI

Clinical Trials for Prevacid

Image of Brigham and Women's Hospital in Boston, United States.

Argon Plasma for Helicobacter Pylori Infection

18+
All Sexes
Boston, MA

The objective of the study is to investigate the efficacy and safety of an argon plasma-based therapy - HEAPE - in treating H. pylori infections during endoscopic procedures. By filling the stomach with sodium chloride solution that is treated with APC (PAL), the Investigators hypothesize a significant reduction in H. pylori. The use of PAL instead of direct application of APC allows for a broader and more homogeneous application throughout the stomach and a faster procedure time, as the fluid bypasses the thermal effects typically associated with higher electrical power settings and focuses on the bactericidal action of PAL. It is a procedure that does not involve thermal ablation of the stomach lining. Thus, side effects should be expected to be as low as possible. Two different PAL generation modalities will be compared in this study: 1. HEAPE direct: This modality is the direct generation of PAL in the stomach. The stomach is filled with sodium chloride solution which is then treated with APC. With HEAPE direct a potential decrease of reactive species is avoided, as the treatment happens directly at the intended location in the H. pylori infected stomach. 2. Pre-HEAPE: This modality features the treatment of sodium chloride with APC outside of the patient in a sterile container. After the APC treatment, the generated PAL is administered into the stomach with a syringe through the working channel of the endoscope. Pre-HEAPE allows an easier handling of the APC probe as the treatment of the sodium chloride solution can be done without an endoscope. To evaluate the immediate effect of this novel treatment approach the metabolic activity of H. pylori will be assessed using a urea breath test (UBT) before and after treatment. A reduction in H. pylori levels can be detected by a reduction in urease activity in the breath test. After the HEAPE procedure, patients are treated with antibiotics (best practice) as they would be under normal circumstances. Four weeks after treatment, another UBT is performed to determine if H. pylori has been eradicated or if additional antibiotic treatment is indicated. This two-arm, randomized, pilot, single-center, prospective clinical study is designed to evaluate the safety, tolerability and proof of concept that PAL has the ability to eradicate or reduce the bacterial load of H. pylori in humans.

Recruiting
Has No Placebo

Brigham and Women's Hospital

Christopher C Thompson, MD

Erbe Elektromedizin GmbH

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