Pantoprazole Sodium

Q: What are the side effects of pantoprazole sodium?

<p>The following are symptoms of uncontrolled <a href="https://www.withpower.com/clinical-trials/diabetes">diabetes</a>: blurred vision, flushed skin, dry mouth, fruit-like breath odor, increased hunger, increased thirst, increased urination, stomach <a href="https://www.withpower.com/clinical-trials/pain">pain</a>, and trouble breathing. If you experience any of these symptoms, please contact your doctor.</p>

Curling Ulcer, Zollinger-Ellison Syndrome, Heartburn + 14 more

Treatment

17 FDA approvals

20 Active Studies for Pantoprazole Sodium

Treatment for

Curling Ulcer

What is Pantoprazole Sodium

PantoprazoleThe Generic name of this drug

Treatment SummaryPantoprazole is a medication used to reduce the amount of stomach acid produced. It is used to treat gastroesophageal reflux disease (GERD), peptic ulcer disease, and other conditions caused by too much stomach acid. It can also be used in combination with other antibiotics to treat infections caused by _H. pylori_. Pantoprazole works by blocking an enzyme that is necessary for acid production in the stomach. Its effects last longer than 24 hours, making it a popular choice for long-term treatment. While it is generally safe and effective, there are some potential side effects associated with long-

Protonix Delayed-releaseis the brand name

image of different drug pills on a surface

Pantoprazole Sodium Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Protonix Delayed-release

Pantoprazole

2000

353

Approved as Treatment by the FDA

Pantoprazole, also called Protonix Delayed-release, is approved by the FDA for 17 uses like Gastric Ulcer and Zollinger-Ellison Syndrome .

Gastric Ulcer

Zollinger-Ellison Syndrome

Helps manage Zollinger-Ellison Syndrome

Gastro-esophageal Reflux Disease (GERD)

Erosive Esophagitis

pathological hypersecretory conditions

Duodenal Ulcer

GERD With Erosive Esophagitis

Symptomatic Gastroesophageal Reflux Disease (sGERD)

Reflux Esophagitis (RE)

conditions where a reduction of gastric acid secretion is required

Healing

Heartburn

Pathological Conditions, Anatomical

Curling Ulcer

Stomach Ulcer

Gastroesophageal Reflux

Gastroesophageal reflux disease

Effectiveness

How Pantoprazole Sodium Affects PatientsPantoprazole reduces the amount of acid in the stomach, and can help relieve symptoms of acid reflux, heal inflammation of the esophagus, and improve patient quality of life. It is generally considered safe and has few drug interactions. However, long-term use of PPIs such as pantoprazole may be linked to increased risk of bacterial infections, reduced absorption of nutrients, and increased risk of bone fractures. It has also been linked to an increased risk of cardiovascular events due to its effect on an enzyme called DDAH. Before taking measurements of chromogranin A or urine screening tests for THC, pantop

How Pantoprazole Sodium works in the bodyHydrochloric acid is a normal part of the stomach, and is formed by a proton pump enzyme in the parietal cells of the stomach. Pantoprazole is a type of proton pump inhibitor, which works by binding to the enzyme and making it unable to create hydrochloric acid. This blocks the formation of hydrochloric acid and stops it from being released into the stomach, reducing acid levels in the stomach and providing relief for conditions such as heartburn.

When to interrupt dosage

The portion of Pantoprazole Sodium is contingent upon the recognized affliction, including Gastric Ulcer, Healing and Heartburn. The degree of dosage can be found in the table below, dependent on the method of administration.

Condition

Dosage

Administration

Stomach Ulcer

, 4.0 mg/mL, 40.0 mg, 20.0 mg

Granule, delayed release, Granule, delayed release - Oral, Intravenous, Injection, powder, for solution, , Injection, powder, for solution - Intravenous, Tablet, delayed release, Tablet, delayed release - Oral, Oral, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injection, powder, lyophilized, for solution

Heartburn

, 4.0 mg/mL, 40.0 mg, 20.0 mg

Curling Ulcer

, 4.0 mg/mL, 40.0 mg, 20.0 mg

Zollinger-Ellison Syndrome

, 4.0 mg/mL, 40.0 mg, 20.0 mg

Pathological Conditions, Anatomical

, 4.0 mg/mL, 40.0 mg, 20.0 mg

Helicobacter Pylori Infection

, 4.0 mg/mL, 40.0 mg, 20.0 mg

Gastroesophageal Reflux

, 4.0 mg/mL, 40.0 mg, 20.0 mg

Erosive Esophagitis

, 4.0 mg/mL, 40.0 mg, 20.0 mg

Critical Illness

, 4.0 mg/mL, 40.0 mg, 20.0 mg

Gastroesophageal reflux disease

, 4.0 mg/mL, 40.0 mg, 20.0 mg

Reflux Esophagitis (RE)

, 4.0 mg/mL, 40.0 mg, 20.0 mg

patients who are unable to continue taking pantoprazole delayed-release tablets

, 4.0 mg/mL, 40.0 mg, 20.0 mg

prophylaxis of Stress Ulcers

, 4.0 mg/mL, 40.0 mg, 20.0 mg

Stress Ulcers

, 4.0 mg/mL, 40.0 mg, 20.0 mg

Heartburn

, 4.0 mg/mL, 40.0 mg, 20.0 mg

conditions where a reduction of gastric acid secretion is required

, 4.0 mg/mL, 40.0 mg, 20.0 mg

Healing

, 4.0 mg/mL, 40.0 mg, 20.0 mg

Warnings

Pantoprazole Sodium Contraindications

Condition

Risk Level

Notes

Pulse Frequency

Do Not Combine

Pulse Frequency

Do Not Combine

Pulse Frequency

Do Not Combine

Pulse Frequency

Do Not Combine

HIV Positive

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Pantoprazole may interact with Pulse Frequency

Severe Hypersensitivity Reactions

Do Not Combine

Pantoprazole may interact with Pulse Frequency

There are 20 known major drug interactions with Pantoprazole Sodium.

Common Pantoprazole Sodium Drug Interactions

Drug Name

Risk Level

Description

Acenocoumarol

Major

The metabolism of Acenocoumarol can be decreased when combined with Pantoprazole.

Atazanavir

Major

The therapeutic efficacy of Atazanavir can be decreased when used in combination with Pantoprazole.

Axitinib

Major

The metabolism of Axitinib can be decreased when combined with Pantoprazole.

Cyclophosphamide

Major

The metabolism of Cyclophosphamide can be decreased when combined with Pantoprazole.

Infigratinib

Major

The serum concentration of Infigratinib can be decreased when it is combined with Pantoprazole.

Pantoprazole Sodium Toxicity & Overdose RiskIn animal studies, pantoprazole was found to be toxic at a dose of 747mg/kg for rats. Long-term studies in rodents have shown that pantoprazole may lead to rare types of stomach tumors, but it is unknown if this is relevant to humans. This drug is considered safe for pregnant women, but it is still advised to only use it when absolutely necessary. Pantoprazole has been found in breast milk from one nursing mother after a single 40mg dose, but it is not known what the effects could be on nursing infants.

image of a doctor in a lab doing drug, clinical research

Pantoprazole Sodium Novel Uses: Which Conditions Have a Clinical Trial Featuring Pantoprazole Sodium?

23 active studies are currently being conducted to assess the efficacy of Pantoprazole Sodium in relieving Gastric Ulcers, Critical Illness and Stress Ulcers.

Condition

Clinical Trials

Trial Phases

conditions where a reduction of gastric acid secretion is required

0 Actively Recruiting

Zollinger-Ellison Syndrome

0 Actively Recruiting

Heartburn

2 Actively Recruiting

Phase 3, Not Applicable

Gastroesophageal reflux disease

0 Actively Recruiting

Curling Ulcer

0 Actively Recruiting

Heartburn

12 Actively Recruiting

Phase 3, Phase 2, Not Applicable

Helicobacter Pylori Infection

2 Actively Recruiting

Not Applicable, Phase 4

Healing

0 Actively Recruiting

Erosive Esophagitis

2 Actively Recruiting

Phase 2, Phase 3

patients who are unable to continue taking pantoprazole delayed-release tablets

0 Actively Recruiting

Pathological Conditions, Anatomical

3 Actively Recruiting

Phase 3, Not Applicable, Phase 2

Reflux Esophagitis (RE)

0 Actively Recruiting

Critical Illness

0 Actively Recruiting

Stress Ulcers

0 Actively Recruiting

Gastroesophageal Reflux

0 Actively Recruiting

Stomach Ulcer

2 Actively Recruiting

Phase 4, Not Applicable

prophylaxis of Stress Ulcers

0 Actively Recruiting

Pantoprazole Sodium Reviews: What are patients saying about Pantoprazole Sodium?

5Patient Review

3/7/2022

Pantoprazole Sodium for Medication Treatment for Healing Erosive Esophagitis

I've been on Pantoprazole 20mg for close to two years now, and it's been amazing. I can eat whatever I want without experiencing any acid reflux! The only side effect is occasionally insomnia, but that's tolerable.

5Patient Review

4/23/2022

Pantoprazole Sodium for Condition in which Stomach Acid is Pushed Into the Esophagus

I've only been on this medication for a short time, but it has already made a huge difference for me. I would highly recommend it to anyone suffering from acid reflux or heartburn.

5Patient Review

2/7/2022

Pantoprazole Sodium for Inflammation of the Esophagus with Erosion

I've been taking Pantoprazole 20mg 2x daily for a little over a year now and it's done wonders for my eroded esophagus and GERD.

5Patient Review

6/8/2022

Pantoprazole Sodium for Increased Stomach Acid from Systemic Mastocytosis

I've been on this medication for nearly 2 years and have not had a single instance of heartburn. Love it!

4.3Patient Review

9/25/2022

Pantoprazole Sodium for Condition in which Stomach Acid is Pushed Into the Esophagus

I started gaining weight at a rate of 3-4 pounds per month. In the span of five months, I went from 220 to 255 pounds.

3.7Patient Review

4/7/2022

Pantoprazole Sodium for Condition in which Stomach Acid is Pushed Into the Esophagus

Pantoprazole was great for my stomach acid problems, but I unfortunately had to stop taking it after learning that it caused a kidney stone.

3Patient Review

4/11/2022

Pantoprazole Sodium for Heartburn

I have never had such negative reactions to a medication before. This caused me immense stomach pain, joint pain, anxiety, depression, brain fog, and made it difficult to concentrate or even stand up without feeling lightheaded.

2Patient Review

7/20/2022

Pantoprazole Sodium for Increased Stomach Acid from Systemic Mastocytosis

Do not bother with this treatment. It might help your stomach, but it gave me such severe anxiety that I felt like I was going crazy. I took it for eight weeks and the feeling only got worse. Finally, I stopped taking it on my own and switched to Zantac--which helped within a few weeks.

1.7Patient Review

8/8/2022

Pantoprazole Sodium for Excessive Production of Stomach Acid

I had much better luck with my reflux before taking this drug. My doctor wanted me to use it as a preventative measure, but unfortunately it made things much worse for me. I stopped taking it after a week and I'm still dealing with throat pain from the acid - almost a month later. Please be careful before you decide to take this medication.

1.7Patient Review

9/6/2022

Pantoprazole Sodium for Condition in which Stomach Acid is Pushed Into the Esophagus

I developed a heart condition after taking this medication for an extended period of time. I'm not sure if the two are related, but it's something to be aware of.

1.7Patient Review

10/30/2022

Pantoprazole Sodium for Inflammation of the Esophagus with Erosion

I found this medicine to be incredibly irritating. It got to the point where I thought it was making me lose my mind. Not only that, but the anxiety from thinking I was losing my mind made my GERD so much worse. This "medicine" came close to driving me to suicide.

1Patient Review

11/18/2021

Pantoprazole Sodium for Increased Stomach Acid from Systemic Mastocytosis

I tried one 40mg tablet and it felt like I had been poisoned. I saw things that weren't there and felt terrible overall. Please remove this product from the market before it hurts anyone else.

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about pantoprazole sodium

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is pantoprazole sodium used for?

"Pantoprazole cuts down on the amount of stomach acid produced. It can be used for heartburn, acid reflux, and gastroesophageal reflux disease (GERD). GERD is a condition where acid reflux occurs frequently. Pantoprazole is also taken to prevent and treat stomach ulcers."

Answered by AI

What are the side effects of pantoprazole sodium?

"The following are symptoms of uncontrolled diabetes: blurred vision, flushed skin, dry mouth, fruit-like breath odor, increased hunger, increased thirst, increased urination, stomach pain, and trouble breathing. If you experience any of these symptoms, please contact your doctor."

Answered by AI

What is pantoprazole sodium 40mg?

"Pantoprazole is used to treat certain stomach and esophagus problems, such as acid reflux. It works by decreasing the amount of acid your stomach makes, which relieves symptoms such as heartburn, difficulty swallowing, and persistent cough."

Answered by AI

What is the best time to take pantoprazole?

"It is typically recommended to take pantoprazole once daily, either before breakfast or 30-60 minutes before a meal. If taking the medication twice daily, take the first dose before breakfast and the second dose before dinner. Swallow the tablets whole; do not split, crush, or chew them."

Answered by AI

Clinical Trials for Pantoprazole Sodium

Have you considered Pantoprazole Sodium clinical trials? We made a collection of clinical trials featuring Pantoprazole Sodium, we think they might fit your search criteria.

Image of Brigham and Women's Hospital in Boston, United States.

Argon Plasma for Helicobacter Pylori Infection

18+

All Sexes

Boston, MA

The objective of the study is to investigate the efficacy and safety of an argon plasma-based therapy - HEAPE - in treating H. pylori infections during endoscopic procedures. By filling the stomach with sodium chloride solution that is treated with APC (PAL), the Investigators hypothesize a significant reduction in H. pylori. The use of PAL instead of direct application of APC allows for a broader and more homogeneous application throughout the stomach and a faster procedure time, as the fluid bypasses the thermal effects typically associated with higher electrical power settings and focuses on the bactericidal action of PAL. It is a procedure that does not involve thermal ablation of the stomach lining. Thus, side effects should be expected to be as low as possible. Two different PAL generation modalities will be compared in this study: 1. HEAPE direct: This modality is the direct generation of PAL in the stomach. The stomach is filled with sodium chloride solution which is then treated with APC. With HEAPE direct a potential decrease of reactive species is avoided, as the treatment happens directly at the intended location in the H. pylori infected stomach. 2. Pre-HEAPE: This modality features the treatment of sodium chloride with APC outside of the patient in a sterile container. After the APC treatment, the generated PAL is administered into the stomach with a syringe through the working channel of the endoscope. Pre-HEAPE allows an easier handling of the APC probe as the treatment of the sodium chloride solution can be done without an endoscope. To evaluate the immediate effect of this novel treatment approach the metabolic activity of H. pylori will be assessed using a urea breath test (UBT) before and after treatment. A reduction in H. pylori levels can be detected by a reduction in urease activity in the breath test. After the HEAPE procedure, patients are treated with antibiotics (best practice) as they would be under normal circumstances. Four weeks after treatment, another UBT is performed to determine if H. pylori has been eradicated or if additional antibiotic treatment is indicated. This two-arm, randomized, pilot, single-center, prospective clinical study is designed to evaluate the safety, tolerability and proof of concept that PAL has the ability to eradicate or reduce the bacterial load of H. pylori in humans.

Recruiting

Has No Placebo

Brigham and Women's HospitalChristopher C Thompson, MDErbe Elektromedizin GmbH

Have you considered Pantoprazole Sodium clinical trials? We made a collection of clinical trials featuring Pantoprazole Sodium, we think they might fit your search criteria.