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What is Pantoprazole Sodium
PantoprazoleThe Generic name of this drug
Treatment SummaryPantoprazole is a medication used to reduce the amount of stomach acid produced. It is used to treat gastroesophageal reflux disease (GERD), peptic ulcer disease, and other conditions caused by too much stomach acid. It can also be used in combination with other antibiotics to treat infections caused by _H. pylori_. Pantoprazole works by blocking an enzyme that is necessary for acid production in the stomach. Its effects last longer than 24 hours, making it a popular choice for long-term treatment. While it is generally safe and effective, there are some potential side effects associated with long-
Protonix Delayed-releaseis the brand name
Pantoprazole Sodium Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Protonix Delayed-release
Pantoprazole
2000
353
Approved as Treatment by the FDA
Pantoprazole, also called Protonix Delayed-release, is approved by the FDA for 11 uses like GERD With Erosive Esophagitis and conditions where a reduction of gastric acid secretion is required .GERD With Erosive Esophagitis
conditions where a reduction of gastric acid secretion is required
Curling Ulcer
Reflux Esophagitis (RE)
Pathological Conditions, Anatomical
Heartburn
Gastroesophageal reflux disease
Erosive Esophagitis
Gastric Ulcer
Healing
Zollinger-Ellison Syndrome
Helps manage Zollinger-Ellison Syndrome
Effectiveness
How Pantoprazole Sodium Affects PatientsPantoprazole reduces the amount of acid in the stomach, and can help relieve symptoms of acid reflux, heal inflammation of the esophagus, and improve patient quality of life. It is generally considered safe and has few drug interactions. However, long-term use of PPIs such as pantoprazole may be linked to increased risk of bacterial infections, reduced absorption of nutrients, and increased risk of bone fractures. It has also been linked to an increased risk of cardiovascular events due to its effect on an enzyme called DDAH. Before taking measurements of chromogranin A or urine screening tests for THC, pantop
How Pantoprazole Sodium works in the bodyHydrochloric acid is a normal part of the stomach, and is formed by a proton pump enzyme in the parietal cells of the stomach. Pantoprazole is a type of proton pump inhibitor, which works by binding to the enzyme and making it unable to create hydrochloric acid. This blocks the formation of hydrochloric acid and stops it from being released into the stomach, reducing acid levels in the stomach and providing relief for conditions such as heartburn.
When to interrupt dosage
The portion of Pantoprazole Sodium is contingent upon the recognized affliction, including Gastric Ulcer, Healing and Heartburn. The degree of dosage can be found in the table below, dependent on the method of administration.Condition
Dosage
Administration
Stress Ulcers
, 4.0 mg/mL, 40.0 mg, 20.0 mg
, Oral, Tablet, delayed release, Tablet, delayed release - Oral, Granule, delayed release, Granule, delayed release - Oral, Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
GERD With Erosive Esophagitis
, 4.0 mg/mL, 40.0 mg, 20.0 mg
, Oral, Tablet, delayed release, Tablet, delayed release - Oral, Granule, delayed release, Granule, delayed release - Oral, Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Erosive Esophagitis
, 4.0 mg/mL, 40.0 mg, 20.0 mg
, Oral, Tablet, delayed release, Tablet, delayed release - Oral, Granule, delayed release, Granule, delayed release - Oral, Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
conditions where a reduction of gastric acid secretion is required
, 4.0 mg/mL, 40.0 mg, 20.0 mg
, Oral, Tablet, delayed release, Tablet, delayed release - Oral, Granule, delayed release, Granule, delayed release - Oral, Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Gastroesophageal reflux disease
, 4.0 mg/mL, 40.0 mg, 20.0 mg
, Oral, Tablet, delayed release, Tablet, delayed release - Oral, Granule, delayed release, Granule, delayed release - Oral, Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Helicobacter Pylori Infection
, 4.0 mg/mL, 40.0 mg, 20.0 mg
, Oral, Tablet, delayed release, Tablet, delayed release - Oral, Granule, delayed release, Granule, delayed release - Oral, Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Heartburn
, 4.0 mg/mL, 40.0 mg, 20.0 mg
, Oral, Tablet, delayed release, Tablet, delayed release - Oral, Granule, delayed release, Granule, delayed release - Oral, Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Gastric Ulcer
, 4.0 mg/mL, 40.0 mg, 20.0 mg
, Oral, Tablet, delayed release, Tablet, delayed release - Oral, Granule, delayed release, Granule, delayed release - Oral, Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Curling Ulcer
, 4.0 mg/mL, 40.0 mg, 20.0 mg
, Oral, Tablet, delayed release, Tablet, delayed release - Oral, Granule, delayed release, Granule, delayed release - Oral, Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Reflux Esophagitis (RE)
, 4.0 mg/mL, 40.0 mg, 20.0 mg
, Oral, Tablet, delayed release, Tablet, delayed release - Oral, Granule, delayed release, Granule, delayed release - Oral, Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
patients who are unable to continue taking pantoprazole delayed-release tablets
, 4.0 mg/mL, 40.0 mg, 20.0 mg
, Oral, Tablet, delayed release, Tablet, delayed release - Oral, Granule, delayed release, Granule, delayed release - Oral, Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Pathological Conditions, Anatomical
, 4.0 mg/mL, 40.0 mg, 20.0 mg
, Oral, Tablet, delayed release, Tablet, delayed release - Oral, Granule, delayed release, Granule, delayed release - Oral, Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Zollinger-Ellison Syndrome
, 4.0 mg/mL, 40.0 mg, 20.0 mg
, Oral, Tablet, delayed release, Tablet, delayed release - Oral, Granule, delayed release, Granule, delayed release - Oral, Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Critical Illness
, 4.0 mg/mL, 40.0 mg, 20.0 mg
, Oral, Tablet, delayed release, Tablet, delayed release - Oral, Granule, delayed release, Granule, delayed release - Oral, Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Healing
, 4.0 mg/mL, 40.0 mg, 20.0 mg
, Oral, Tablet, delayed release, Tablet, delayed release - Oral, Granule, delayed release, Granule, delayed release - Oral, Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
prophylaxis of Stress Ulcers
, 4.0 mg/mL, 40.0 mg, 20.0 mg
, Oral, Tablet, delayed release, Tablet, delayed release - Oral, Granule, delayed release, Granule, delayed release - Oral, Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Heartburn
, 4.0 mg/mL, 40.0 mg, 20.0 mg
, Oral, Tablet, delayed release, Tablet, delayed release - Oral, Granule, delayed release, Granule, delayed release - Oral, Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Warnings
Pantoprazole Sodium ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
HIV Positive
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Pantoprazole may interact with Pulse Frequency
Severe Hypersensitivity Reactions
Do Not Combine
Pantoprazole may interact with Pulse Frequency
Common Pantoprazole Sodium Drug Interactions
Drug Name
Risk Level
Description
Acenocoumarol
Major
The metabolism of Acenocoumarol can be decreased when combined with Pantoprazole.
Atazanavir
Major
The therapeutic efficacy of Atazanavir can be decreased when used in combination with Pantoprazole.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Pantoprazole.
Cyclophosphamide
Major
The metabolism of Cyclophosphamide can be decreased when combined with Pantoprazole.
Infigratinib
Major
The serum concentration of Infigratinib can be decreased when it is combined with Pantoprazole.
Pantoprazole Sodium Toxicity & Overdose RiskIn animal studies, pantoprazole was found to be toxic at a dose of 747mg/kg for rats. Long-term studies in rodents have shown that pantoprazole may lead to rare types of stomach tumors, but it is unknown if this is relevant to humans. This drug is considered safe for pregnant women, but it is still advised to only use it when absolutely necessary. Pantoprazole has been found in breast milk from one nursing mother after a single 40mg dose, but it is not known what the effects could be on nursing infants.
Pantoprazole Sodium Novel Uses: Which Conditions Have a Clinical Trial Featuring Pantoprazole Sodium?
23 active studies are currently being conducted to assess the efficacy of Pantoprazole Sodium in relieving Gastric Ulcers, Critical Illness and Stress Ulcers.Condition
Clinical Trials
Trial Phases
Curling Ulcer
0 Actively Recruiting
Zollinger-Ellison Syndrome
0 Actively Recruiting
Helicobacter Pylori Infection
0 Actively Recruiting
Reflux Esophagitis (RE)
0 Actively Recruiting
Pathological Conditions, Anatomical
0 Actively Recruiting
Erosive Esophagitis
3 Actively Recruiting
Phase 2, Phase 3
Gastroesophageal reflux disease
0 Actively Recruiting
GERD With Erosive Esophagitis
0 Actively Recruiting
Healing
0 Actively Recruiting
patients who are unable to continue taking pantoprazole delayed-release tablets
0 Actively Recruiting
Stress Ulcers
0 Actively Recruiting
Critical Illness
0 Actively Recruiting
Heartburn
14 Actively Recruiting
Phase 3, Phase 2, Not Applicable, Phase 4, Phase 1
conditions where a reduction of gastric acid secretion is required
0 Actively Recruiting
Gastric Ulcer
1 Actively Recruiting
Phase 4
Heartburn
2 Actively Recruiting
Phase 3, Not Applicable
prophylaxis of Stress Ulcers
0 Actively Recruiting
Pantoprazole Sodium Reviews: What are patients saying about Pantoprazole Sodium?
5Patient Review
3/7/2022 I've been on Pantoprazole 20mg for close to two years now, and it's been amazing. I can eat whatever I want without experiencing any acid reflux! The only side effect is occasionally insomnia, but that's tolerable.
5Patient Review
4/23/2022 I've only been on this medication for a short time, but it has already made a huge difference for me. I would highly recommend it to anyone suffering from acid reflux or heartburn.
5Patient Review
2/7/2022 I've been taking Pantoprazole 20mg 2x daily for a little over a year now and it's done wonders for my eroded esophagus and GERD.
5Patient Review
6/8/2022 I've been on this medication for nearly 2 years and have not had a single instance of heartburn. Love it!
4.3Patient Review
9/25/2022 I started gaining weight at a rate of 3-4 pounds per month. In the span of five months, I went from 220 to 255 pounds.
3.7Patient Review
4/7/2022 Pantoprazole was great for my stomach acid problems, but I unfortunately had to stop taking it after learning that it caused a kidney stone.
3Patient Review
4/11/2022 I have never had such negative reactions to a medication before. This caused me immense stomach pain, joint pain, anxiety, depression, brain fog, and made it difficult to concentrate or even stand up without feeling lightheaded.
2Patient Review
7/20/2022 Do not bother with this treatment. It might help your stomach, but it gave me such severe anxiety that I felt like I was going crazy. I took it for eight weeks and the feeling only got worse. Finally, I stopped taking it on my own and switched to Zantac--which helped within a few weeks.
1.7Patient Review
8/8/2022 I had much better luck with my reflux before taking this drug. My doctor wanted me to use it as a preventative measure, but unfortunately it made things much worse for me. I stopped taking it after a week and I'm still dealing with throat pain from the acid - almost a month later. Please be careful before you decide to take this medication.
1.7Patient Review
9/6/2022 I developed a heart condition after taking this medication for an extended period of time. I'm not sure if the two are related, but it's something to be aware of.
1.7Patient Review
10/30/2022 I found this medicine to be incredibly irritating. It got to the point where I thought it was making me lose my mind. Not only that, but the anxiety from thinking I was losing my mind made my GERD so much worse. This "medicine" came close to driving me to suicide.
1Patient Review
11/18/2021 I tried one 40mg tablet and it felt like I had been poisoned. I saw things that weren't there and felt terrible overall. Please remove this product from the market before it hurts anyone else.
Patient Q&A Section about pantoprazole sodium
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is pantoprazole sodium used for?
"Pantoprazole cuts down on the amount of stomach acid produced. It can be used for heartburn, acid reflux, and gastroesophageal reflux disease (GERD). GERD is a condition where acid reflux occurs frequently. Pantoprazole is also taken to prevent and treat stomach ulcers."
Answered by AI
What are the side effects of pantoprazole sodium?
"The following are symptoms of uncontrolled diabetes: blurred vision, flushed skin, dry mouth, fruit-like breath odor, increased hunger, increased thirst, increased urination, stomach pain, and trouble breathing. If you experience any of these symptoms, please contact your doctor."
Answered by AI
What is pantoprazole sodium 40mg?
"Pantoprazole is used to treat certain stomach and esophagus problems, such as acid reflux. It works by decreasing the amount of acid your stomach makes, which relieves symptoms such as heartburn, difficulty swallowing, and persistent cough."
Answered by AI
What is the best time to take pantoprazole?
"It is typically recommended to take pantoprazole once daily, either before breakfast or 30-60 minutes before a meal. If taking the medication twice daily, take the first dose before breakfast and the second dose before dinner. Swallow the tablets whole; do not split, crush, or chew them."
Answered by AI