MRI-Guided Internal Radiation for Cervical and Vaginal Cancer
Trial Summary
Do I need to stop my current medications for the trial?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
What data supports the effectiveness of the treatment MRI-Guided Internal Radiation for Cervical and Vaginal Cancer?
Research shows that MRI-guided brachytherapy, a type of internal radiation, can significantly reduce tumor size in cervical cancer patients, with 11 out of 15 patients experiencing more than 80% tumor shrinkage. MRI helps in precisely targeting the cancer while minimizing damage to nearby organs, making it a valuable tool in treatment planning.12345
Is MRI-guided internal radiation therapy safe for humans?
How is MRI-guided internal radiation therapy for cervical and vaginal cancer different from other treatments?
MRI-guided internal radiation therapy, also known as brachytherapy, is unique because it uses MRI to precisely target the tumor, allowing for better dose optimization to the cancer while minimizing exposure to surrounding healthy organs. This approach can improve treatment accuracy and reduce side effects compared to traditional methods that may not use MRI for guidance.123910
What is the purpose of this trial?
This trial studies how well magnetic resonance imaging (MRI)-guided internal radiation therapy (brachytherapy) works in treating participants with human papillomavirus (HPV) associated stage IB2-IV cervical or stage II-IVA vaginal cancer. Using MRI guidance during brachytherapy applicator placement may improve treatment planning in participants with cervical or vaginal cancer.
Research Team
Ann H. Klopp
Principal Investigator
M.D. Anderson Cancer Center
Eligibility Criteria
This trial is for women with stage IB2-IVA cervical cancer or stage II-IVA vaginal cancer, recommended to receive chemoradiation including brachytherapy. It's not suitable for those with non-MRI-compatible anatomy, pacemakers, defibrillators, or conditions that prevent MRI use.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants undergo MRI-guided internal radiation therapy (brachytherapy) for cervical or vaginal cancer
Follow-up
Participants are monitored for safety, effectiveness, and disease recurrence after treatment
Treatment Details
Interventions
- Internal Radiation Therapy
- MRI-Guided Brachytherapy
Find a Clinic Near You
Who Is Running the Clinical Trial?
M.D. Anderson Cancer Center
Lead Sponsor
National Cancer Institute (NCI)
Collaborator