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HD-tDCS + Language Therapy for Primary Progressive Aphasia
Study Summary
This trial is testing whether electrical stimulation can help improve language skills in people with neurodegenerative disorders that cause language deficits.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
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- People who are left-handed.I am between 50 and 80 years old.You use your right hand more often than your left hand.I have been diagnosed with Primary Progressive Aphasia or dementia.You must be diagnosed with primary progressive aphasia (PPA) or its variants at specialized dementia clinics at certain medical centers in the US.I have been diagnosed with Logopenic Variant Primary Progressive Aphasia.The researchers will include 30 healthy people who are similar in age and education level to the participants, usually their spouses, to make sure they have similar language and thinking abilities.I am between 50 and 80 years old.I have a history of neurological or psychiatric conditions.You have hearing loss that has not been treated or fixed.You have very severe memory or language problems, as shown by specific tests.I have a history of neurological diseases like stroke or learning disabilities.You have not corrected your vision loss.
- Group 1: Sham + Language/Cognitive Intervention(s) first
- Group 2: Active HD-tDCS + Language/Cognitive Intervention(s) first
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: You will receive the treatment for 30 null
- Follow Ups: You may be asked to continue sharing information regarding the trial for 1 Months after you stop receiving the treatment.
Frequently Asked Questions
What is the current enrollment number for this clinical experiment?
"Affirmative. According to data on clinicaltrials.gov, this research study is presently recruiting individuals for participation. This trial was first posted in August of 2019 and most recently updated in June 2022; it seeks a total of 60 patients from one medical site."
Would I be an eligible participant for this clinical research?
"This clinical study seeks 60 participants afflicted with Pick Disease of the brain, between 45-75 years old. In addition to this key requirement, applicants must have a high school diploma and be right-handed; additionally, 30 healthy age and education matched controls are expected in order to maintain homogeneity amongst language and cognitive performance measures."
Are there currently openings for patient participation in this experiment?
"Afirmation. Clinicaltrials.gov affirms that this research endeavor, which was published on August 28th 2019, is actively seeking patients for enrollment. The experiment requires 60 volunteers from a singular site to complete the trial."
What are the objectives of this trial?
"The primary outcome being monitored in this clinical trial will be the change in percent accuracy on word repetition (no delay) assessed by Temple Assessment of Language and Short-Term Memory in Aphasia (TALSA) Test 3, measured over a period before intervention, immediately after, 1 month post-, and 3 months post-intervention. Other outcomes include the change in digit span forward score which assesses rote immediate verbal memory; Northwestern Anagram Test (NAT), which gauges syntax accuracy; as well as NAVS - Sentence Comprehension Test score measuring comprehension across multiple sentence types. All changes are evaluated with an increase representing"
Does this clinical trial have an age restriction, and if so, what is it?
"The age range for this clinical trial is from 45 to 75 years old."
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What portion of applicants met pre-screening criteria?
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