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Inside Nurtec

Introduction and Basic Information

Safety and Precautions

Uses and Effectiveness

Comparative Analysis

Cost and Administration

Nurtec ODT Overview, Mechanism, and Dosage Guidelines

Nurtec ODT (rimegepant) is a prescription medication approved for the acute treatment of migraine attacks with or without aura in adults. It is provided as an orally disintegrating tablet (ODT) that dissolves in the mouth, eliminating the need for water. This characteristic makes Nurtec ODT a convenient option for individuals who are traveling or have difficulty swallowing pills.

Migraines are believed to be partially caused by increased activity of a molecule known as CGRP (Calcitonin Gene-Related Peptide). CGRP is significant in causing inflammation and pain during migraine attacks. Nurtec ODT functions by blocking CGRP receptors, which prevents the peptide from binding to them. By inhibiting CGRP's action, Nurtec ODT aims to relieve migraine symptoms and terminate the attack.

The recommended dosage of Nurtec ODT is one 75 mg tablet taken orally once a day as needed for migraine attacks. The tablet is designed to be placed on or under the tongue, where it dissolves quickly. There is no requirement to consume it with water, enhancing its ease of use.

  • It is important to adhere to the guidance not to exceed more than one dose within a 24-hour period due to the risk of potential side effects such as nausea and dizziness.
  • Prior to the initiation of Nurtec ODT, an evaluation of the patient's health history is critical.

This overview provides information on the use of Nurtec ODT for the treatment of migraine in adults, detailing its mechanism of action and dosage guidelines.

Side Effects and Considerations Before Taking Nurtec

Nurtec, a prescription medication used for treating migraine headaches in adults, comes with potential side effects and other considerations.

While Nurtec is generally well-tolerated, it may cause side effects. Common side effects include:

  • Nausea
  • Stomach pain
  • Indigestion

Less common but more serious side effects might also occur, including allergic reactions characterized by symptoms such as rash, itching, swelling of the face or throat, severe dizziness, and trouble breathing. Immediate medical attention is necessary if these symptoms appear following the intake of Nurtec.

Several factors need to be considered when evaluating Nurtec for migraine treatment:

  1. Liver problems or kidney issues should be assessed.
  2. A comprehensive list of currently taken medications should be reviewed to avoid drug interactions.
  3. The effects of Nurtec on an unborn baby or breast milk are not fully known, necessitating a consultation for pregnant or nursing mothers.

Medication Overuse Headaches: The risk of medication-overuse headaches exists when Nurtec is used frequently over a long period, resulting in headaches that become more frequent and persistent.

In addition to medication, lifestyle changes could contribute to reducing the frequency of migraines.

This information aims to provide an understanding of the benefits and risks associated with Nurtec for migraine relief.

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Nurtec for Migraine and Cluster Headache Treatment

Nurtec ODT (orally disintegrating tablet) is a prescription medication designed for the treatment of migraine and cluster headaches. It contains rimegepant, which functions by blocking CGRP receptors. CGRP (Calcitonin Gene-Related Peptide) is significant in the development of migraine pain. The blockade of these receptors by Nurtec can diminish the frequency and severity of migraine attacks.

The medication offers a dual functionality, serving not only to treat an ongoing attack but also as a preventive measure when utilized regularly, distinguishing it among headache treatments currently available.

In the context of cluster headaches, while Nurtec is primarily approved for migraine management, its effectiveness may also benefit some patients with cluster headaches, attributed to the similar underlying mechanisms involving CGRP. However, individual responses may vary.

The administration of Nurtec is through an orally disintegrating tablet placed under the tongue, allowing for rapid dissolution without the need for water. This feature is particularly beneficial during severe headache episodes. Potential side effects include nausea or drowsiness, although they are generally mild.

In summary:

  • Nurtec ODT is a medication containing rimegepant.
  • Its mechanism of action involves blocking CGRP receptors to reduce migraine pain.
  • It is applicable for patients with frequent migraines and, in some instances, those with cluster headaches.
  • The method of administration is via dissolving the tablet under the tongue, eliminating the need for water.

The suitability of Nurtec based on medical history and specific health conditions is determined through a comprehensive evaluation.

Comparing Migraine Medications Including Nurtec

Migraines affect millions worldwide, creating a demand for effective treatments. Among the plethora of options, comparing medications is essential for patients seeking relief. This article focuses on various migraine medications, including a newer option: Nurtec.

Doctors typically prescribe two types of medication for migraines: preventive and acute treatment drugs. Preventive medications aim to reduce the frequency and severity of migraines over time, including beta-blockers like propranolol and metoprolol, anticonvulsants such as topiramate, and antidepressants.

For immediate relief during a migraine attack, acute treatment medications are used. Common choices are NSAIDs (e.g., ibuprofen), triptans (like sumatriptan), and ergots.

Nurtec ODT (rimegepant) represents a new class called CGRP receptor antagonists, designed specifically for acute migraine treatment and also approved for preventive use. Unlike traditional medications that often provide only partial relief or have significant side effects, Nurtec dissolves quickly under the tongue, offering fast-acting results with fewer reported side effects.

  • Effectiveness varies across these options:

    • Triptans: Effective in relieving pain but may not be suitable for those with cardiovascular issues due to constriction of blood vessels.
    • NSAIDs: An initial choice but can lead to gastrointestinal problems if used frequently.
    • CGRP Antagonists (including Nurtec): Show promise in both preventing onset when taken regularly and stopping migraines once they've started, without the cardiovascular risks associated with triptans.
  • Side effects also vary widely among these categories:

    • Triptans may cause dizziness or sensations of warmth/tingling.
    • NSAIDs might increase risk factors related to heart health or stomach ulcers.
    • Nurtec ODT's common side effects are somewhat milder, with nausea occasionally reported but generally less severe than the adverse impacts of traditional options.

This overview indicates the evolving landscape of migraine treatment options, highlighting the introduction of new medications like Nurtec which offer different benefits and side effect profiles compared to more traditional therapies.

Cost, Savings, and Administering Nurtec ODT

Nurtec ODT is a prescription medication for the acute treatment of migraine in adults. Understanding its cost, potential savings options, and the correct administration method is important for effective management.


The cost of Nurtec ODT can vary based on factors including insurance coverage, pharmacy location, and access to savings programs or coupons. Without insurance or discounts, the price may be higher. Healthcare providers or pharmacists may provide information on the current cost and suggest ways to obtain Nurtec at a lower price.


There are ways to save on Nurtec ODT:

  • Manufacturer Coupons: The manufacturer of Nurtec ODT offers coupons or vouchers that can reduce the out-of-pocket costs.
  • Insurance Coverage: Some insurance plans cover a portion of the cost.
  • Patient Assistance Programs: These programs are available for those who qualify based on financial need or lack of insurance.

Exploring these options could lead to substantial savings.

Administering Nurtec ODT

Proper administration of Nurtec is crucial for its effectiveness:

  1. The tablet should not be removed from its blister pack until ready to use.
  2. It should be placed directly under the tongue to dissolve quickly.
  3. Water is not required, but eating or drinking should be avoided within 15 minutes before and after taking the tablet until it has dissolved completely.

Understanding the cost and administration of medications like Nurtec ODT is important for effective management.