Amnesteem

Sezary Syndrome, refractory Acne vulgaris, Acne Conglobata + 4 more
Treatment
20 Active Studies for Amnesteem

What is Amnesteem

IsotretinoinThe Generic name of this drug
Treatment SummaryIsotretinoin is a vitamin A-based drug used to treat severe, long-lasting acne. It was previously sold under the brand name Accutane, but is no longer available. Because of the potential risks to a developing baby, isotretinoin is only available in the US through the iPLEDGE program. This medication was approved by the FDA in 1982.
Accutaneis the brand name
image of different drug pills on a surface
Amnesteem Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Accutane
Isotretinoin
1982
78

Effectiveness

How Amnesteem Affects PatientsThe way isotretinoin works in the body is not yet fully understood.
How Amnesteem works in the bodyIsotretinoin works by changing how cells grow, divide, survive and die. This helps reduce the amount of sebum, or oil, produced by the body and prevents blockages in pores that can lead to acne. Isotretinoin also causes sebaceous cells to die, while decreasing inflammation. It also changes the environment of the skin to make it less hospitable to acne-causing bacteria. Scientists are still investigating how isotretinoin works, but there is evidence that it may interact with a certain protein to explain some of its effects.

When to interrupt dosage

The prescribed measure of Amnesteem is contingent upon the acknowledged state, for example Acne conglobata, Acne Vulgaris and Pregnancy. The measure of dosage is subject to the technique of delivery (e.g. Capsule - Oral or Capsule) delineated in the table underneath.
Condition
Dosage
Administration
Sezary Syndrome
, 10.0 mg, 20.0 mg, 40.0 mg, 30.0 mg, 0.05 %, 25.0 mg, 35.0 mg, 8.0 mg, 24.0 mg, 28.0 mg, 16.0 mg, 32.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Topical, Gel, Gel - Topical
refractory Acne vulgaris
, 10.0 mg, 20.0 mg, 40.0 mg, 30.0 mg, 0.05 %, 25.0 mg, 35.0 mg, 8.0 mg, 24.0 mg, 28.0 mg, 16.0 mg, 32.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Topical, Gel, Gel - Topical
Rosacea
, 10.0 mg, 20.0 mg, 40.0 mg, 30.0 mg, 0.05 %, 25.0 mg, 35.0 mg, 8.0 mg, 24.0 mg, 28.0 mg, 16.0 mg, 32.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Topical, Gel, Gel - Topical
Acne Vulgaris
, 10.0 mg, 20.0 mg, 40.0 mg, 30.0 mg, 0.05 %, 25.0 mg, 35.0 mg, 8.0 mg, 24.0 mg, 28.0 mg, 16.0 mg, 32.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Topical, Gel, Gel - Topical
early Mycosis Fungoides (MF)
, 10.0 mg, 20.0 mg, 40.0 mg, 30.0 mg, 0.05 %, 25.0 mg, 35.0 mg, 8.0 mg, 24.0 mg, 28.0 mg, 16.0 mg, 32.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Topical, Gel, Gel - Topical
Neuroblastoma (NB)
, 10.0 mg, 20.0 mg, 40.0 mg, 30.0 mg, 0.05 %, 25.0 mg, 35.0 mg, 8.0 mg, 24.0 mg, 28.0 mg, 16.0 mg, 32.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Topical, Gel, Gel - Topical
Acne Conglobata
, 10.0 mg, 20.0 mg, 40.0 mg, 30.0 mg, 0.05 %, 25.0 mg, 35.0 mg, 8.0 mg, 24.0 mg, 28.0 mg, 16.0 mg, 32.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Topical, Gel, Gel - Topical

Warnings

Amnesteem Contraindications
Condition
Risk Level
Notes
history of basal cell carcinoma
Do Not Combine
Squamous cell carcinoma
Do Not Combine
history of squamous cell
Do Not Combine
family history of basal cell carcinoma
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Isotretinoin may interact with Pulse Frequency
There are 20 known major drug interactions with Amnesteem.
Common Amnesteem Drug Interactions
Drug Name
Risk Level
Description
Clomocycline
Major
The risk or severity of pseudotumor cerebri can be increased when Isotretinoin is combined with Clomocycline.
Demeclocycline
Major
The risk or severity of pseudotumor cerebri can be increased when Isotretinoin is combined with Demeclocycline.
Doxycycline
Major
The risk or severity of pseudotumor cerebri can be increased when Isotretinoin is combined with Doxycycline.
Eravacycline
Major
The risk or severity of pseudotumor cerebri can be increased when Isotretinoin is combined with Eravacycline.
Metacycline
Major
The risk or severity of pseudotumor cerebri can be increased when Isotretinoin is combined with Metacycline.
Amnesteem Toxicity & Overdose RiskOverdosing on Isotretinoin may cause vomiting, flushed skin, dry and cracked lips, abdominal pain, headache, dizziness, and loss of balance. The lowest toxic dose for children is 30mg/kg, 24mg/kg for men, and 56mg/kg for women. Animal tests have found that Isotretinoin can increase the risk of tumors and abnormal growths in the adrenal gland at doses higher than the recommended clinical dose. It has also been linked to testicular atrophy in dogs. No effects have been seen on sperm count or fertility in humans.
image of a doctor in a lab doing drug, clinical research

Amnesteem Novel Uses: Which Conditions Have a Clinical Trial Featuring Amnesteem?

65 active trials are currently being conducted to evaluate the merits of Amnesteem in providing relief from Rosacea, Neuroblastoma (NB) and Acne conglobata.
Condition
Clinical Trials
Trial Phases
Acne Vulgaris
0 Actively Recruiting
Acne Conglobata
0 Actively Recruiting
refractory Acne vulgaris
0 Actively Recruiting
early Mycosis Fungoides (MF)
0 Actively Recruiting
Rosacea
8 Actively Recruiting
Not Applicable, Early Phase 1, Phase 2, Phase 4
Sezary Syndrome
18 Actively Recruiting
Phase 2, Phase 1
Neuroblastoma (NB)
1 Actively Recruiting
Early Phase 1

Amnesteem Reviews: What are patients saying about Amnesteem?

5Patient Review
3/27/2010
Amnesteem for Severe Difficult to Treat Nodular Acne
I've been using this product for four months now and I'm thrilled with the results. My skin is clearing up beautifully, and I'm getting a lot of compliments on how great it looks. If you're considering this treatment, I would highly recommend it.
5Patient Review
9/19/2010
Amnesteem for Severe Difficult to Treat Nodular Acne
Unfortunately, this medication caused me a lot of irritation. My face and back were extremely red, and I also started bleeding from my rectum.
4.7Patient Review
9/25/2010
Amnesteem for Severe Difficult to Treat Nodular Acne
I've been using this treatment for 18 days now and have seen significant results. I'm not entirely happy with the dryness it's caused, but the redness of my skin is gone and I breakout much less frequently. Acne was a huge problem for me before trying this, to the point where I had tried everything else possible without success. This medication has really helped me out.
4.3Patient Review
4/16/2011
Amnesteem for Severe Difficult to Treat Nodular Acne
I had pretty severe dry skin before I started using this treatment, but it's been working great! The flakiness around my chin and nose has almost entirely stopped, and my lips are a lot less dry.
4.3Patient Review
1/8/2008
Amnesteem for Severe Difficult to Treat Nodular Acne
2Patient Review
1/4/2022
Amnesteem for Severe Difficult to Treat Nodular Acne
The medicine is effective, but the side effects are very intense. Ipledge also caused me to miss almost a month's worth of treatments, which was extremely frustrating.
1Patient Review
3/21/2015
Amnesteem for Severe Difficult to Treat Nodular Acne
We gave this medication to our grandson and it has made him extremely drowsy, unable to focus, and very depressed. We strongly advise against taking this drug and urge you to explore healthier alternatives!
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about amnesteem

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How quickly does Amnesteem work?

"The acne may get worse when first starting to take the drug, but should start to improve after a few months. If the acne comes back after stopping the medication, a second course may be necessary."

Answered by AI

What does Amnesteem do to your body?

"Amnesteem is a prescription medication used to treat the most severe form of acne, nodular acne. It belongs to a group of drugs called retinoids and is thought to work by preventing oil production in the glands under the skin. The medication comes in capsule form and is usually taken twice daily with food."

Answered by AI

Is Accutane and Amnesteem the same?

"Accutane and Amnesteem, both forms of vitamin A called retinoids, are used for the treatment and prevention of severe acne. Accutane is no longer available in the U.S., but generic versions are."

Answered by AI

Clinical Trials for Amnesteem

Have you considered Amnesteem clinical trials? We made a collection of clinical trials featuring Amnesteem, we think they might fit your search criteria.
Have you considered Amnesteem clinical trials? We made a collection of clinical trials featuring Amnesteem, we think they might fit your search criteria.
Have you considered Amnesteem clinical trials? We made a collection of clinical trials featuring Amnesteem, we think they might fit your search criteria.
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