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What is Claravis
IsotretinoinThe Generic name of this drug
Treatment SummaryIsotretinoin is a derivative of vitamin A used to treat severe acne. It was previously sold under the brand name Accutane, but is no longer available. Isotretinoin is associated with major risks in pregnancy, so it must be prescribed according to the iPLEDGE program in the United States. Isotretinoin was first approved by the FDA in 1982.
Accutaneis the brand name
Claravis Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Accutane
Isotretinoin
1982
78
Effectiveness
How Claravis Affects PatientsIt is not well understood how isotretinoin works in the body.
How Claravis works in the bodyIsotretinoin works to prevent and treat acne in multiple ways. It reduces the amount of sebum (oil) produced by the skin, which helps unblock pores and prevent the growth of bacteria that causes acne. It also induces apoptosis (cell death) in sebaceous cells, which further decreases sebum production. Isotretinoin also reduces hyperkeratinization and inflammation, and can make the environment less hospitable for acne-causing bacteria. There is also some evidence that it interacts with FoxO1, which may explain some of its additional effects.
When to interrupt dosage
The proposed dosage of Claravis is contingent upon the diagnosed state, including Acne conglobata, Acne Vulgaris and Pregnancy. The measure of dosage varies, as per the administration technique (e.g. Capsule - Oral or Capsule) pointed out in the table beneath.Condition
Dosage
Administration
Sezary Syndrome
, 10.0 mg, 20.0 mg, 40.0 mg, 30.0 mg, 0.05 %, 25.0 mg, 35.0 mg, 8.0 mg, 24.0 mg, 28.0 mg, 16.0 mg, 32.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Topical, Gel, Gel - Topical
refractory Acne vulgaris
, 10.0 mg, 20.0 mg, 40.0 mg, 30.0 mg, 0.05 %, 25.0 mg, 35.0 mg, 8.0 mg, 24.0 mg, 28.0 mg, 16.0 mg, 32.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Topical, Gel, Gel - Topical
Rosacea
, 10.0 mg, 20.0 mg, 40.0 mg, 30.0 mg, 0.05 %, 25.0 mg, 35.0 mg, 8.0 mg, 24.0 mg, 28.0 mg, 16.0 mg, 32.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Topical, Gel, Gel - Topical
Acne Vulgaris
, 10.0 mg, 20.0 mg, 40.0 mg, 30.0 mg, 0.05 %, 25.0 mg, 35.0 mg, 8.0 mg, 24.0 mg, 28.0 mg, 16.0 mg, 32.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Topical, Gel, Gel - Topical
early Mycosis Fungoides (MF)
, 10.0 mg, 20.0 mg, 40.0 mg, 30.0 mg, 0.05 %, 25.0 mg, 35.0 mg, 8.0 mg, 24.0 mg, 28.0 mg, 16.0 mg, 32.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Topical, Gel, Gel - Topical
Neuroblastoma (NB)
, 10.0 mg, 20.0 mg, 40.0 mg, 30.0 mg, 0.05 %, 25.0 mg, 35.0 mg, 8.0 mg, 24.0 mg, 28.0 mg, 16.0 mg, 32.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Topical, Gel, Gel - Topical
Acne Conglobata
, 10.0 mg, 20.0 mg, 40.0 mg, 30.0 mg, 0.05 %, 25.0 mg, 35.0 mg, 8.0 mg, 24.0 mg, 28.0 mg, 16.0 mg, 32.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Topical, Gel, Gel - Topical
Warnings
Claravis ContraindicationsCondition
Risk Level
Notes
history of basal cell carcinoma
Do Not Combine
Squamous cell carcinoma
Do Not Combine
history of squamous cell
Do Not Combine
family history of basal cell carcinoma
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Isotretinoin may interact with Pulse Frequency
Common Claravis Drug Interactions
Drug Name
Risk Level
Description
Clomocycline
Major
The risk or severity of pseudotumor cerebri can be increased when Isotretinoin is combined with Clomocycline.
Demeclocycline
Major
The risk or severity of pseudotumor cerebri can be increased when Isotretinoin is combined with Demeclocycline.
Doxycycline
Major
The risk or severity of pseudotumor cerebri can be increased when Isotretinoin is combined with Doxycycline.
Eravacycline
Major
The risk or severity of pseudotumor cerebri can be increased when Isotretinoin is combined with Eravacycline.
Metacycline
Major
The risk or severity of pseudotumor cerebri can be increased when Isotretinoin is combined with Metacycline.
Claravis Toxicity & Overdose RiskSymptoms of an isotretinoin overdose may include vomiting, flushed skin, cracked lips, abdominal pain, headache, dizziness, and trouble with balance. Generally, no treatment is needed for a mild overdose. The lowest dose known to cause toxic effects in children is 30mg/kg/21W, 24mg/kg/4W in men, and 56mg/kg/8W in women. In animal studies, isotretinoin has been linked to an increased risk of tumors, mutation in cells, and testicular atrophy when taken in doses much higher than the recommended dose. There are no known effects on sperm count
Claravis Novel Uses: Which Conditions Have a Clinical Trial Featuring Claravis?
65 active clinical trials are examining the potential of Claravis to address Rosacea, Neuroblastoma (NB) and Acne conglobata.Condition
Clinical Trials
Trial Phases
Acne Vulgaris
0 Actively Recruiting
Acne Conglobata
0 Actively Recruiting
refractory Acne vulgaris
0 Actively Recruiting
early Mycosis Fungoides (MF)
0 Actively Recruiting
Rosacea
8 Actively Recruiting
Not Applicable, Early Phase 1, Phase 2, Phase 4
Sezary Syndrome
18 Actively Recruiting
Phase 2, Phase 1
Neuroblastoma (NB)
1 Actively Recruiting
Early Phase 1
Claravis Reviews: What are patients saying about Claravis?
5Patient Review
1/12/2019 I've had skin issues for a very long time, and this is the best treatment I've found. Not only did it work quickly (under two months), but it also lasted longer than other treatments I've tried.
5Patient Review
3/3/2017 I've only been on this medication for a week, but I had to jump through a lot of hoops just to get the prescription. So far, the only side effect I've noticed is dry skin; however, I am hopeful that this will be an effective treatment for my condition.
5Patient Review
7/28/20135Patient Review
3/15/2019 I'm a 66-year-old man who's dealt with skin problems for most of my life. They come and go in cycles, and this was the worst one I've had since my teenage years. Accutane helped for a while about 20 years ago, but eventually my skin started breaking out again. I tried Claravis for two months and it worked like a charm! My skin cleared up completely, so I stopped taking the medication in hopes that this will be the last time I have to deal with these outbreaks.
4.3Patient Review
11/25/2015 I am finally acne free. I will still get the occasional small pimple but nothing like I used to get. I also struggled with cystic acne. Now if I get a pimple it is gone by the next day. I did not get fully clear until a month after I finished Claravis.
4Patient Review
9/25/2014 I'm 60 years old, and this medication did wonders for me. I had been on long-term antibiotics for 3 years before trying this, and the only side effect I experienced was severe drying of my lips.
3.7Patient Review
11/28/2016 As a 71-year-old white male, I've only been taking this medication for about a month. So far, it seems to be working; my acne is starting to clear up. That said, it initially made my acne worse (as my doctor warned me it might), and I've also experienced dry lips and eyes, as well as some stomach upset. Hopefully I'll only have to take the medication for another two months.
2Patient Review
8/7/2013Patient Q&A Section about claravis
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is Claravis same as Accutane?
"If your provider has recommended isotretinoin to you because you have severe acne that has not responded to other treatments, you may be wondering what it is. Isotretinoin is a medication that was previously sold under the brand name Accutane, but is now available under a number of other brand names. These include Claravis, Zenatane, and Absorica."
Answered by AI
What are side effects of Claravis?
"If you experience any of the following symptoms, you may be dehydrated: dryness of your skin, lips, eyes, or nose (you may have nosebleeds); vision problems; headache, back pain, joint pain, muscle problems; skin reactions; or cold symptoms such as stuffy nose, sneezing, sore throat."
Answered by AI
What is Claravis used for?
"This medication is used to treat severe cystic acne that has not responded to other treatment options. These treatment options could include benzoyl peroxide or clindamycin applied directly to the skin, or tetracycline or minocycline taken orally. This medication belongs to a class of drugs called retinoids."
Answered by AI
What does Claravis do to the skin?
"Claravis is a prescription medication that is used to treat the most severe form of acne, called nodular acne. Claravis belongs to a group of drugs called retinoids, and it is thought to work by preventing oil production in glands under the skin. This medication comes in the form of a capsule, and it is usually taken twice daily, with food."
Answered by AI