Dynacin

Rocky Mountain Spotted Fever, Relapsing Fever, Trachoma + 22 more
Treatment
4 Active Studies for Dynacin

What is Dynacin

MinocyclineThe Generic name of this drug
Treatment SummaryMinocycline is an antibiotic used to treat bacterial infections. It was discovered in 1966 and approved by the FDA in 1971. Minocycline belongs to a group of drugs called tetracyclines and has been modified to make it more effective than other tetracyclines. It works against both gram-positive and gram-negative bacteria.
Minocinis the brand name
image of different drug pills on a surface
Dynacin Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Minocin
Minocycline
1990
305

Effectiveness

How Dynacin Affects PatientsMinocycline is an antibiotic used to treat bacterial infections. It is typically taken 2-4 times per day. Taking more than 400mg in a day can lead to serious side effects, so patients should be warned of the risks associated with minocycline use, such as tooth and bone development issues, colitis, side effects on the nervous system, and pseudotumor cerebri.
How Dynacin works in the bodyTetracyclines enter bacteria and stop protein synthesis by blocking the ribosomes. They do this by diffusing into the bacterial cytoplasm and attaching to cations like magnesium. This allows them to move into the periplasm and stop the binding of aminoacyl-tRNA to the ribosome. This prevents the bacteria from creating proteins, which is essential for survival.

When to interrupt dosage

The quantity of Dynacin is contingent upon the determined disorder, including Periodontitis, Rickettsialpox and Lymphogranuloma Venereum. The amount of dosage can be found in the table below, based on the technique of delivery (e.g. Capsule, extended release or Tablet, film coated, extended release).
Condition
Dosage
Administration
Gum Disease
, 75.0 mg, 45.0 mg, 90.0 mg, 135.0 mg, 50.0 mg, 100.0 mg, 80.0 mg, 1.0 mg, 65.0 mg, 115.0 mg, 55.0 mg, 105.0 mg, 67.5 mg, 112.5 mg, 0.04 mg/mg, 0.015 mg/mg, 1.0 mg/mg
, Oral, Capsule - Oral, Capsule, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Kit, Tablet - Oral, Tablet, Intravenous, Injection, Injection - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, Powder - Oral, Topical, Aerosol, foam - Topical, Aerosol, foam
Campylobacter fetus
, 75.0 mg, 45.0 mg, 90.0 mg, 135.0 mg, 50.0 mg, 100.0 mg, 80.0 mg, 1.0 mg, 65.0 mg, 115.0 mg, 55.0 mg, 105.0 mg, 67.5 mg, 112.5 mg, 0.04 mg/mg, 0.015 mg/mg, 1.0 mg/mg
, Oral, Capsule - Oral, Capsule, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Kit, Tablet - Oral, Tablet, Intravenous, Injection, Injection - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, Powder - Oral, Topical, Aerosol, foam - Topical, Aerosol, foam
Psittacosis
, 75.0 mg, 45.0 mg, 90.0 mg, 135.0 mg, 50.0 mg, 100.0 mg, 80.0 mg, 1.0 mg, 65.0 mg, 115.0 mg, 55.0 mg, 105.0 mg, 67.5 mg, 112.5 mg, 0.04 mg/mg, 0.015 mg/mg, 1.0 mg/mg
, Oral, Capsule - Oral, Capsule, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Kit, Tablet - Oral, Tablet, Intravenous, Injection, Injection - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, Powder - Oral, Topical, Aerosol, foam - Topical, Aerosol, foam
Brucellosis
, 75.0 mg, 45.0 mg, 90.0 mg, 135.0 mg, 50.0 mg, 100.0 mg, 80.0 mg, 1.0 mg, 65.0 mg, 115.0 mg, 55.0 mg, 105.0 mg, 67.5 mg, 112.5 mg, 0.04 mg/mg, 0.015 mg/mg, 1.0 mg/mg
, Oral, Capsule - Oral, Capsule, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Kit, Tablet - Oral, Tablet, Intravenous, Injection, Injection - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, Powder - Oral, Topical, Aerosol, foam - Topical, Aerosol, foam
Lymphogranuloma Venereum
, 75.0 mg, 45.0 mg, 90.0 mg, 135.0 mg, 50.0 mg, 100.0 mg, 80.0 mg, 1.0 mg, 65.0 mg, 115.0 mg, 55.0 mg, 105.0 mg, 67.5 mg, 112.5 mg, 0.04 mg/mg, 0.015 mg/mg, 1.0 mg/mg
, Oral, Capsule - Oral, Capsule, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Kit, Tablet - Oral, Tablet, Intravenous, Injection, Injection - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, Powder - Oral, Topical, Aerosol, foam - Topical, Aerosol, foam
Granuloma Inguinale
, 75.0 mg, 45.0 mg, 90.0 mg, 135.0 mg, 50.0 mg, 100.0 mg, 80.0 mg, 1.0 mg, 65.0 mg, 115.0 mg, 55.0 mg, 105.0 mg, 67.5 mg, 112.5 mg, 0.04 mg/mg, 0.015 mg/mg, 1.0 mg/mg
, Oral, Capsule - Oral, Capsule, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Kit, Tablet - Oral, Tablet, Intravenous, Injection, Injection - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, Powder - Oral, Topical, Aerosol, foam - Topical, Aerosol, foam
Respiratory Tract Infections
, 75.0 mg, 45.0 mg, 90.0 mg, 135.0 mg, 50.0 mg, 100.0 mg, 80.0 mg, 1.0 mg, 65.0 mg, 115.0 mg, 55.0 mg, 105.0 mg, 67.5 mg, 112.5 mg, 0.04 mg/mg, 0.015 mg/mg, 1.0 mg/mg
, Oral, Capsule - Oral, Capsule, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Kit, Tablet - Oral, Tablet, Intravenous, Injection, Injection - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, Powder - Oral, Topical, Aerosol, foam - Topical, Aerosol, foam
Inflammation
, 75.0 mg, 45.0 mg, 90.0 mg, 135.0 mg, 50.0 mg, 100.0 mg, 80.0 mg, 1.0 mg, 65.0 mg, 115.0 mg, 55.0 mg, 105.0 mg, 67.5 mg, 112.5 mg, 0.04 mg/mg, 0.015 mg/mg, 1.0 mg/mg
, Oral, Capsule - Oral, Capsule, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Kit, Tablet - Oral, Tablet, Intravenous, Injection, Injection - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, Powder - Oral, Topical, Aerosol, foam - Topical, Aerosol, foam
Urethritis
, 75.0 mg, 45.0 mg, 90.0 mg, 135.0 mg, 50.0 mg, 100.0 mg, 80.0 mg, 1.0 mg, 65.0 mg, 115.0 mg, 55.0 mg, 105.0 mg, 67.5 mg, 112.5 mg, 0.04 mg/mg, 0.015 mg/mg, 1.0 mg/mg
, Oral, Capsule - Oral, Capsule, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Kit, Tablet - Oral, Tablet, Intravenous, Injection, Injection - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, Powder - Oral, Topical, Aerosol, foam - Topical, Aerosol, foam
Typhus, Endemic Flea-Borne
, 75.0 mg, 45.0 mg, 90.0 mg, 135.0 mg, 50.0 mg, 100.0 mg, 80.0 mg, 1.0 mg, 65.0 mg, 115.0 mg, 55.0 mg, 105.0 mg, 67.5 mg, 112.5 mg, 0.04 mg/mg, 0.015 mg/mg, 1.0 mg/mg
, Oral, Capsule - Oral, Capsule, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Kit, Tablet - Oral, Tablet, Intravenous, Injection, Injection - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, Powder - Oral, Topical, Aerosol, foam - Topical, Aerosol, foam
Rickettsia Infections
, 75.0 mg, 45.0 mg, 90.0 mg, 135.0 mg, 50.0 mg, 100.0 mg, 80.0 mg, 1.0 mg, 65.0 mg, 115.0 mg, 55.0 mg, 105.0 mg, 67.5 mg, 112.5 mg, 0.04 mg/mg, 0.015 mg/mg, 1.0 mg/mg
, Oral, Capsule - Oral, Capsule, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Kit, Tablet - Oral, Tablet, Intravenous, Injection, Injection - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, Powder - Oral, Topical, Aerosol, foam - Topical, Aerosol, foam
Cat-Scratch Disease
, 75.0 mg, 45.0 mg, 90.0 mg, 135.0 mg, 50.0 mg, 100.0 mg, 80.0 mg, 1.0 mg, 65.0 mg, 115.0 mg, 55.0 mg, 105.0 mg, 67.5 mg, 112.5 mg, 0.04 mg/mg, 0.015 mg/mg, 1.0 mg/mg
, Oral, Capsule - Oral, Capsule, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Kit, Tablet - Oral, Tablet, Intravenous, Injection, Injection - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, Powder - Oral, Topical, Aerosol, foam - Topical, Aerosol, foam
Dental Root Planing
, 75.0 mg, 45.0 mg, 90.0 mg, 135.0 mg, 50.0 mg, 100.0 mg, 80.0 mg, 1.0 mg, 65.0 mg, 115.0 mg, 55.0 mg, 105.0 mg, 67.5 mg, 112.5 mg, 0.04 mg/mg, 0.015 mg/mg, 1.0 mg/mg
, Oral, Capsule - Oral, Capsule, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Kit, Tablet - Oral, Tablet, Intravenous, Injection, Injection - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, Powder - Oral, Topical, Aerosol, foam - Topical, Aerosol, foam
Plague
, 75.0 mg, 45.0 mg, 90.0 mg, 135.0 mg, 50.0 mg, 100.0 mg, 80.0 mg, 1.0 mg, 65.0 mg, 115.0 mg, 55.0 mg, 105.0 mg, 67.5 mg, 112.5 mg, 0.04 mg/mg, 0.015 mg/mg, 1.0 mg/mg
, Oral, Capsule - Oral, Capsule, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Kit, Tablet - Oral, Tablet, Intravenous, Injection, Injection - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, Powder - Oral, Topical, Aerosol, foam - Topical, Aerosol, foam
Acne Vulgaris
, 75.0 mg, 45.0 mg, 90.0 mg, 135.0 mg, 50.0 mg, 100.0 mg, 80.0 mg, 1.0 mg, 65.0 mg, 115.0 mg, 55.0 mg, 105.0 mg, 67.5 mg, 112.5 mg, 0.04 mg/mg, 0.015 mg/mg, 1.0 mg/mg
, Oral, Capsule - Oral, Capsule, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Kit, Tablet - Oral, Tablet, Intravenous, Injection, Injection - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, Powder - Oral, Topical, Aerosol, foam - Topical, Aerosol, foam
Rickettsialpox
, 75.0 mg, 45.0 mg, 90.0 mg, 135.0 mg, 50.0 mg, 100.0 mg, 80.0 mg, 1.0 mg, 65.0 mg, 115.0 mg, 55.0 mg, 105.0 mg, 67.5 mg, 112.5 mg, 0.04 mg/mg, 0.015 mg/mg, 1.0 mg/mg
, Oral, Capsule - Oral, Capsule, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Kit, Tablet - Oral, Tablet, Intravenous, Injection, Injection - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, Powder - Oral, Topical, Aerosol, foam - Topical, Aerosol, foam
Disease
, 75.0 mg, 45.0 mg, 90.0 mg, 135.0 mg, 50.0 mg, 100.0 mg, 80.0 mg, 1.0 mg, 65.0 mg, 115.0 mg, 55.0 mg, 105.0 mg, 67.5 mg, 112.5 mg, 0.04 mg/mg, 0.015 mg/mg, 1.0 mg/mg
, Oral, Capsule - Oral, Capsule, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Kit, Tablet - Oral, Tablet, Intravenous, Injection, Injection - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, Powder - Oral, Topical, Aerosol, foam - Topical, Aerosol, foam
Rocky Mountain Spotted Fever
, 75.0 mg, 45.0 mg, 90.0 mg, 135.0 mg, 50.0 mg, 100.0 mg, 80.0 mg, 1.0 mg, 65.0 mg, 115.0 mg, 55.0 mg, 105.0 mg, 67.5 mg, 112.5 mg, 0.04 mg/mg, 0.015 mg/mg, 1.0 mg/mg
, Oral, Capsule - Oral, Capsule, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Kit, Tablet - Oral, Tablet, Intravenous, Injection, Injection - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, Powder - Oral, Topical, Aerosol, foam - Topical, Aerosol, foam
Relapsing Fever
, 75.0 mg, 45.0 mg, 90.0 mg, 135.0 mg, 50.0 mg, 100.0 mg, 80.0 mg, 1.0 mg, 65.0 mg, 115.0 mg, 55.0 mg, 105.0 mg, 67.5 mg, 112.5 mg, 0.04 mg/mg, 0.015 mg/mg, 1.0 mg/mg
, Oral, Capsule - Oral, Capsule, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Kit, Tablet - Oral, Tablet, Intravenous, Injection, Injection - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, Powder - Oral, Topical, Aerosol, foam - Topical, Aerosol, foam
Trachoma
, 75.0 mg, 45.0 mg, 90.0 mg, 135.0 mg, 50.0 mg, 100.0 mg, 80.0 mg, 1.0 mg, 65.0 mg, 115.0 mg, 55.0 mg, 105.0 mg, 67.5 mg, 112.5 mg, 0.04 mg/mg, 0.015 mg/mg, 1.0 mg/mg
, Oral, Capsule - Oral, Capsule, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Kit, Tablet - Oral, Tablet, Intravenous, Injection, Injection - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, Powder - Oral, Topical, Aerosol, foam - Topical, Aerosol, foam

Warnings

Dynacin has two contraindications. It should not be utilized if you are encountering any of the conditions specified in the following table.Dynacin Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Minocycline may interact with Pulse Frequency
There are 20 known major drug interactions with Dynacin.
Common Dynacin Drug Interactions
Drug Name
Risk Level
Description
Amdinocillin
Major
The therapeutic efficacy of Amdinocillin can be decreased when used in combination with Minocycline.
Amoxicillin
Major
The therapeutic efficacy of Amoxicillin can be decreased when used in combination with Minocycline.
Ampicillin
Major
The therapeutic efficacy of Ampicillin can be decreased when used in combination with Minocycline.
Aspoxicillin
Major
The therapeutic efficacy of Aspoxicillin can be decreased when used in combination with Minocycline.
Azidocillin
Major
The therapeutic efficacy of Azidocillin can be decreased when used in combination with Minocycline.
Dynacin Toxicity & Overdose RiskThe lowest toxic dose of minocycline in rats is 2380mg/kg and in mice is 3600mg/kg. The lowest toxic dose in rats when given by injection is 331mg/kg, and in mice is 299mg/kg. When given under the skin, the lowest toxic dose in rats is 1700mg/kg and in mice is 2290mg/kg.Those who overdose on minocycline may experience dizziness, nausea, and vomiting. If this occurs, it is important to stop taking minocycline and seek medical support.
image of a doctor in a lab doing drug, clinical research

Dynacin Novel Uses: Which Conditions Have a Clinical Trial Featuring Dynacin?

Ten ongoing investigations are examining the potential of Dynacin for the alleviation of Psittacosis, Tularemia and other Diseases.
Condition
Clinical Trials
Trial Phases
Gum Disease
3 Actively Recruiting
Phase 3, Not Applicable
Trachoma
1 Actively Recruiting
Phase 4
Lymphogranuloma Venereum
0 Actively Recruiting
Disease
0 Actively Recruiting
Psittacosis
0 Actively Recruiting
Respiratory Tract Infections
0 Actively Recruiting
Dental Scaling
0 Actively Recruiting
Typhus, Endemic Flea-Borne
0 Actively Recruiting
Acne Vulgaris
0 Actively Recruiting
Relapsing Fever
0 Actively Recruiting
Plague
0 Actively Recruiting
Cat-Scratch Disease
0 Actively Recruiting
Rocky Mountain Spotted Fever
0 Actively Recruiting
Inflammation
0 Actively Recruiting
Brucellosis
0 Actively Recruiting
Rickettsia Infections
0 Actively Recruiting
Chancroid
0 Actively Recruiting
Q Fever
0 Actively Recruiting
Conjunctivitis, Inclusion
0 Actively Recruiting
Rickettsialpox
0 Actively Recruiting

Dynacin Reviews: What are patients saying about Dynacin?

4.7Patient Review
1/4/2010
Dynacin for Skin Infection
I had a bad case of Rosacea and this was the medication that helped me. I started seeing results immediately, which was great; however, the side effects were pretty tough to deal with. The constant nausea and dizziness made it hard to function at times. Thankfully, after four months of treatment, the Rosacea was gone for good.
4.3Patient Review
9/6/2008
Dynacin for Acne
This is a great product and it works well. I would definitely recommend it to others.
4Patient Review
1/18/2010
Dynacin for Acne
I unfortunately developed a debilitating yeast infection while taking this medication
3.7Patient Review
9/24/2009
Dynacin for Bacterial Infection due to Deer Fly, Flea & Tick Bites
I have degenerated disc disease and Lyme Disease, both of which cause me a great deal of pain.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about dynacin

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the drug minocycline used for?

"Minocycline capsules are used to treat a variety of bacterial infections. They are also used to treat anthrax infection and other infections in patients who cannot receive penicillins. Minocycline belongs to a class of antibiotics called tetracyclines."

Answered by AI

What is dynacin used to treat?

"DYNACIN is an antibiotic medication that belongs to the tetracycline class. It is used to treat infections caused by bacteria, including skin infections, respiratory infections, urinary tract infections, some sexually transmitted diseases, and others. In severe cases of acne, DYNACIN may be used in combination with other treatments."

Answered by AI

What is Minocin 100mg used for?

"Minocin is an antibiotic that is used to treat many different bacterial infections. It is available in generic form."

Answered by AI

What infections is minocycline used for?

"Minocycline is an antibiotic used to treat various types of infections caused by bacteria. These infections include pneumonia, other respiratory tract infections, certain types of skin infections, eye infections, certain infections of the lymphatic system, intestinal infections, genital infections, and urinary infections. Additionally, minocycline can be used to treat certain infections that are spread by ticks, lice, mites, and infected animals."

Answered by AI

Clinical Trials for Dynacin

Image of Office of Dental Health, Department of Health and Senior Services in Jefferson City, United States.

Dental Care for Pneumonia Prevention

60 - 100
All Sexes
Jefferson City, MO
The goal of this study is to learn if dental infection control treatment delivered to older adult nursing home residents at their place of residence will result in : * improved dental health * reduced risk of pneumonia * better glucose control for diabetic patients compared to the pre-project dental and general health evaluations of residents and the pre-project facility incidence of pneumonia. Dental infection control treatment includes treating gum infections, stopping or slowing decay with fluoride, and assisting residents with effective tooth brushing and denture cleaning daily. Previous studies indicate dental infections can be inhaled and cause pneumonia or make diabetes worse. A shortage of dentists has limited care for nursing home residents. This project will allow dental hygienists and specially trained dental assistants to treat nursing home residents using telehealth methods (computers, cameras, internet, and telephone) to talk and work with dentists in different locations.
Recruiting
Has No Placebo
Office of Dental Health, Department of Health and Senior Services
Image of University of Alabame in Birmingham, United States.

Antibiotics for Gum Disease

18+
All Sexes
Birmingham, AL
Periodontitis is a bacterial inflammatory disease and antibiotic use is being empirically used as part of its treatment. However, a clinical practice guideline on periodontal treatment adjuncts published in 2015 identified weak evidence on the use of systemic antibiotics and large heterogeneity across small scale studies, suggesting that larger pragmatic clinical trials would benefit clinical decision making. This will be a prospective, randomized, placebo-controlled trial, stratified by practice and practitioner. The study will investigate the effectiveness of adjunctive antibiotics as adjunct to scaling and root planing (SRP) compared to SRP with placebo for the treatment of generalized stage II-III, grades A-C periodontitis in patient participants from National Dental PBRN practices. Periodontal data will be collected at baseline, re-evaluation (6 weeks), and final (4-12 months) study visits. Changes in periodontal clinical and patient-reported outcomes will be assessed to determine the effectiveness of SRP plus adjunctive systemic Amoxicillin / Metronidazole antibiotics (AMXM) versus SRP with Placebo.
Phase 3
Recruiting
University of AlabameGeorgios Kotsakis, DDS
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