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What is Gantrisin
Acetyl sulfisoxazoleThe Generic name of this drug
Treatment SummarySulfisoxazole acetyl is a type of antibiotic that works by preventing bacteria from being able to make folic acid. When combined with erythromycin, it is used to treat ear infections caused by Haemophilus influenzae. It prevents the enzyme dihydropteroate synthase from combining PABA (a compound found in bacteria) with dihydrofolic acid, which is needed for making folic acid. This ultimately leads to the death of the bacteria.
Gantrisinis the brand name
Gantrisin Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Gantrisin
Acetyl sulfisoxazole
1953
5
Approved as Treatment by the FDA
Acetyl sulfisoxazole, otherwise known as Gantrisin, is approved by the FDA for 15 uses including Malaria and Toxoplasmosis .Malaria
Toxoplasmosis
Used in combination with Pyrimethamine for Toxoplasmosis
Acute Otitis Media caused by Haemophilus Influenzae
Used to treat Acute Otitis Media caused by Haemophilus Influenzae in combination with Erythromycin
Meningitis caused by Haemophilus influenzae
Used in combination with Streptomycin for Meningitis caused by Haemophilus influenzae
Conjunctivitis, Inclusion
Nocardiosis
Chancroid
Trachoma
Klebsiella
Foreign Bodies
Klebsiella
Meningococcal Meningitis
organism demonstrated to be susceptible
prophylaxis of Meningococcal meningitis
Sulfonamides
Effectiveness
How Gantrisin Affects PatientsSulfisoxazole is an antibiotic that works to stop the growth of bacteria. It works by blocking an important part of the bacteria's metabolism cycle. If bacteria are resistant to one sulfonamide, they are usually resistant to all. This drug is not generally used for meningitis anymore, but it can still be found in high levels in the cerebrospinal fluid when meningeal infections occur. Its effectiveness as an antibiotic is reduced in the presence of pus.
How Gantrisin works in the bodySulfisoxazole works by targeting an enzyme called dihydropteroate synthetase. This enzyme is responsible for the production of folic acid in bacteria. Sulfisoxazole stops it from working correctly by blocking a reaction between a pteridine and para-aminobenzoic acid (PABA). Without this reaction, bacteria can't make folic acid and are unable to survive.
When to interrupt dosage
The prescribed measure of Gantrisin is contingent upon the established issue, such as the organism demonstrated to be susceptible, Sulfonamides and Toxoplasmosis. The quantity of dosage fluctuates, in line with the approach of administration depicted in the table beneath.Condition
Dosage
Administration
Meningitis caused by Haemophilus influenzae
500.0 mg/mL, , 600.0 mg/mL
, Oral, Suspension, Suspension - Oral, Granule, for suspension, Granule, for suspension - Oral, Powder, for suspension - Oral, Powder, for suspension
prophylaxis of Meningococcal meningitis
500.0 mg/mL, , 600.0 mg/mL
, Oral, Suspension, Suspension - Oral, Granule, for suspension, Granule, for suspension - Oral, Powder, for suspension - Oral, Powder, for suspension
Malaria
500.0 mg/mL, , 600.0 mg/mL
, Oral, Suspension, Suspension - Oral, Granule, for suspension, Granule, for suspension - Oral, Powder, for suspension - Oral, Powder, for suspension
Sulfonamides
500.0 mg/mL, , 600.0 mg/mL
, Oral, Suspension, Suspension - Oral, Granule, for suspension, Granule, for suspension - Oral, Powder, for suspension - Oral, Powder, for suspension
organism demonstrated to be susceptible
500.0 mg/mL, , 600.0 mg/mL
, Oral, Suspension, Suspension - Oral, Granule, for suspension, Granule, for suspension - Oral, Powder, for suspension - Oral, Powder, for suspension
Chancroid
500.0 mg/mL, , 600.0 mg/mL
, Oral, Suspension, Suspension - Oral, Granule, for suspension, Granule, for suspension - Oral, Powder, for suspension - Oral, Powder, for suspension
Trachoma
500.0 mg/mL, , 600.0 mg/mL
, Oral, Suspension, Suspension - Oral, Granule, for suspension, Granule, for suspension - Oral, Powder, for suspension - Oral, Powder, for suspension
Toxoplasmosis
500.0 mg/mL, , 600.0 mg/mL
, Oral, Suspension, Suspension - Oral, Granule, for suspension, Granule, for suspension - Oral, Powder, for suspension - Oral, Powder, for suspension
Conjunctivitis, Inclusion
500.0 mg/mL, , 600.0 mg/mL
, Oral, Suspension, Suspension - Oral, Granule, for suspension, Granule, for suspension - Oral, Powder, for suspension - Oral, Powder, for suspension
Meningococcal Meningitis
500.0 mg/mL, , 600.0 mg/mL
, Oral, Suspension, Suspension - Oral, Granule, for suspension, Granule, for suspension - Oral, Powder, for suspension - Oral, Powder, for suspension
Klebsiella
500.0 mg/mL, , 600.0 mg/mL
, Oral, Suspension, Suspension - Oral, Granule, for suspension, Granule, for suspension - Oral, Powder, for suspension - Oral, Powder, for suspension
Klebsiella
500.0 mg/mL, , 600.0 mg/mL
, Oral, Suspension, Suspension - Oral, Granule, for suspension, Granule, for suspension - Oral, Powder, for suspension - Oral, Powder, for suspension
Acute Otitis Media caused by Haemophilus Influenzae
500.0 mg/mL, , 600.0 mg/mL
, Oral, Suspension, Suspension - Oral, Granule, for suspension, Granule, for suspension - Oral, Powder, for suspension - Oral, Powder, for suspension
Foreign Bodies
500.0 mg/mL, , 600.0 mg/mL
, Oral, Suspension, Suspension - Oral, Granule, for suspension, Granule, for suspension - Oral, Powder, for suspension - Oral, Powder, for suspension
Nocardiosis
500.0 mg/mL, , 600.0 mg/mL
, Oral, Suspension, Suspension - Oral, Granule, for suspension, Granule, for suspension - Oral, Powder, for suspension - Oral, Powder, for suspension
Warnings
There are 20 known major drug interactions with Gantrisin.Common Gantrisin Drug Interactions
Drug Name
Risk Level
Description
Acenocoumarol
Major
The metabolism of Acenocoumarol can be decreased when combined with Acetyl sulfisoxazole.
Cabozantinib
Major
The metabolism of Cabozantinib can be decreased when combined with Acetyl sulfisoxazole.
Capecitabine
Major
The metabolism of Capecitabine can be decreased when combined with Acetyl sulfisoxazole.
Cyclopentamine
Major
The risk or severity of adverse effects can be increased when Acetyl sulfisoxazole is combined with Cyclopentamine.
Cyclophosphamide
Major
The metabolism of Cyclophosphamide can be decreased when combined with Acetyl sulfisoxazole.
Gantrisin Toxicity & Overdose RiskSulfisoxazole has a toxic dose of 6,800mg/kg in mice. In rare cases, it can cause severe allergic reactions such as Stevens-Johnson syndrome and toxic epidermal necrolysis. It can also cause low white and red blood cell count, low platelets, liver damage, and hemolysis, as well as kidney damage, pain in the lower back, and tubular necrosis. Other known side effects include appetite loss, diarrhea, rashes, itching, nausea, and vomiting. If a person takes too much sulfisoxazole, continuous forced diuresis and alkaline
Gantrisin Novel Uses: Which Conditions Have a Clinical Trial Featuring Gantrisin?
Two active trials are investigating the potential of Gantrisin to target Klebsiella, Acute Otitis Media caused by Haemophilus Influenzae, and Foreign Bodies.Condition
Clinical Trials
Trial Phases
Trachoma
1 Actively Recruiting
Phase 4
Sulfonamides
0 Actively Recruiting
Toxoplasmosis
1 Actively Recruiting
Phase 4
prophylaxis of Meningococcal meningitis
0 Actively Recruiting
organism demonstrated to be susceptible
0 Actively Recruiting
Meningitis caused by Haemophilus influenzae
0 Actively Recruiting
Klebsiella
0 Actively Recruiting
Meningococcal Meningitis
0 Actively Recruiting
Conjunctivitis, Inclusion
0 Actively Recruiting
Acute Otitis Media caused by Haemophilus Influenzae
0 Actively Recruiting
Malaria
0 Actively Recruiting
Klebsiella
0 Actively Recruiting
Chancroid
0 Actively Recruiting
Foreign Bodies
0 Actively Recruiting
Nocardiosis
0 Actively Recruiting
Gantrisin Reviews: What are patients saying about Gantrisin?
5Patient Review
11/6/2010 My daughter used to get ear infections frequently, but her doctor recommended this treatment. We gave it to her every day for four to six months, and she hasn't had an infection in ten years now!
Patient Q&A Section about gantrisin
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is azo Gantrisin?
"Azo Gantrisin is a brand name medication that includes short acting sulfonamides and other urologicals. The medication is used to relieve symptoms of urinary tract infections. The active ingredient in Azo Gantrisin is Phenazopyridine, Sulfafurazole."
Answered by AI
What drug class is Sulfisoxazole?
"Sulfisoxazole is an antibiotic that is used to treat or prevent infections in many different parts of the body. It belongs to the group of medicines known as sulfonamide antibiotics."
Answered by AI
What is the generic name for Gantrisin?
".
This document contains information on sulfisoxazole side effects. Some of the dosage forms listed on this page may not apply to the brand name Gantrisin."
Answered by AI
What is the drug Gantrisin used for?
"Gantrisin (acetyl sulfisoxazole pediatric suspension) is a type of antibiotic called a sulfonamide ("sulfa") used to treat or prevent many different types of infections caused by bacteria, such as bladder infections, ear infections, or meningitis. The brand name Gantrisin is no longer being made, but there may be generic versions available."
Answered by AI