Questran Light

Q: Is there an alternative to Questran Light?

<p>If questran &#x26; colesevelam are not available from your local pharmacies, colestipol granules (Brand name Cholestid) is the only alternative bile acid sequestrant available.</p>

Hardening of the Arteries, partial biliary obstruction, Itching + 1 more

Treatment

5 FDA approvals

20 Active Studies for Questran Light

Treatment for

Hardening of the Arteries

What is Questran Light

CholestyramineThe Generic name of this drug

Treatment SummaryCholestyramine is a medication that helps your body get rid of bile acid. It is a type of polymeric compound that binds to bile acid and helps it be eliminated from the body. Cholestyramine is not soluble in water, but it is very good at absorbing liquids.

Cholestyramine Lightis the brand name

image of different drug pills on a surface

Questran Light Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Cholestyramine Light

Cholestyramine

1994

Approved as Treatment by the FDA

Cholestyramine, commonly known as Cholestyramine Light, is approved by the FDA for 5 uses like Hardening of the Arteries and Primary Hypercholesterolemia .

Hardening of the Arteries

Helps manage Atherosclerosis

Primary Hypercholesterolemia

partial biliary obstruction

Itching

Pruritus

Effectiveness

How Questran Light Affects PatientsCholesterol is needed to create bile acids, which help with digestion. Normally, bile acids are secreted into the intestines and absorbed back into the liver. Cholestyramine resin binds with the bile acids in the intestines, forming an insoluble complex that gets passed out in the feces. This helps to prevent the bile acids from being reabsorbed and thus lowers their levels in the body.

How Questran Light works in the bodyCholestyramine is a medication that helps reduce the reabsorption of bile acids in the digestive tract. It works by sticking to anionic bile acids and forming a strong resin matrix. This creates an exchange of chloride anions with the bile acid particles. The medication is made up of a quaternary ammonium group attached to an inert styrene-divinylbenzene copolymer.

When to interrupt dosage

The measure of Questran Light rests on the diagnosed condition, such as Hardening of the arteries, Itch and Primary Hypercholesterolemia. The portion likewise changes in accordance with the mode of delivery (e.g. Oral or Powder, for suspension) given in the table beneath.

Condition

Dosage

Administration

Itching

, 4.0 mg/mg, 4000.0 mg, 1000.0 mg, 400000.0 mg, 4000.0 mg/dose

, Oral, Powder, for suspension, Powder, for suspension - Oral, Powder, for solution, Powder, for solution - Oral, Tablet, Tablet - Oral, Kit; Powder - Oral, Kit; Powder, Powder, Powder - Oral, Powder; Suspension - Oral, Powder; Suspension

Hardening of the Arteries

, 4.0 mg/mg, 4000.0 mg, 1000.0 mg, 400000.0 mg, 4000.0 mg/dose

partial biliary obstruction

, 4.0 mg/mg, 4000.0 mg, 1000.0 mg, 400000.0 mg, 4000.0 mg/dose

Primary Hypercholesterolemia

, 4.0 mg/mg, 4000.0 mg, 1000.0 mg, 400000.0 mg, 4000.0 mg/dose

Warnings

Questran Light Contraindications

Condition

Risk Level

Notes

complete biliary obstruction

Do Not Combine

There are 20 known major drug interactions with Questran Light.

Common Questran Light Drug Interactions

Drug Name

Risk Level

Description

Mycophenolate mofetil

Major

Cholestyramine may increase the excretion rate of Mycophenolate mofetil which could result in a lower serum level and potentially a reduction in efficacy.

Mycophenolic acid

Major

Cholestyramine may increase the excretion rate of Mycophenolic acid which could result in a lower serum level and potentially a reduction in efficacy.

Raloxifene

Major

Cholestyramine can cause a decrease in the absorption of Raloxifene resulting in a reduced serum concentration and potentially a decrease in efficacy.

(R)-warfarin

Minor

Cholestyramine can cause a decrease in the absorption of (R)-warfarin resulting in a reduced serum concentration and potentially a decrease in efficacy.

(S)-Warfarin

Minor

Cholestyramine can cause a decrease in the absorption of (S)-Warfarin resulting in a reduced serum concentration and potentially a decrease in efficacy.

Questran Light Toxicity & Overdose RiskOverdosing on the drug may lead to an obstruction in the stomach or intestines.

image of a doctor in a lab doing drug, clinical research

Questran Light Novel Uses: Which Conditions Have a Clinical Trial Featuring Questran Light?

68 active studies are in progress to assess the potential of Questran Light to ameliorate Itch, partial biliary obstruction, and Primary Hypercholesterolemia.

Condition

Clinical Trials

Trial Phases

Primary Hypercholesterolemia

8 Actively Recruiting

Phase 3, Phase 2, Not Applicable

Itching

2 Actively Recruiting

Phase 3, Not Applicable

partial biliary obstruction

0 Actively Recruiting

Hardening of the Arteries

18 Actively Recruiting

Not Applicable, Phase 4, Phase 2, Phase 3

Questran Light Reviews: What are patients saying about Questran Light?

5Patient Review

4/7/2015

Questran Light for Chronic Diarrhea

This medication has been a life-saver. I was struggling with severe diarrhea and couldn't leave the house without constant worry. After just six months of taking one sachet per day, I no longer have any issues.

5Patient Review

5/25/2012

Questran Light for Chronic Diarrhea

I've been struggling with chronic diarrhea for six years now, and this medication has finally allowed me to have some semblance of a normal life again. I can't thank Questran enough!

5Patient Review

2/22/2008

Questran Light for Chronic Diarrhea

4.7Patient Review

1/19/2019

Questran Light for Chronic Diarrhea

Questtan Lite has been a godsend for my Lymphocytic Colitis. I was on steroids for two months prior, but I was still having to use the restroom several times per day. Since starting this medication, though, that urgency has gone away and I've had fewer trips to the bathroom overall.

4.7Patient Review

10/26/2009

Questran Light for Chronic Diarrhea

Questran Light has been fantastic for me since having my gallbladder removed. It's completely stopped the chronic diarrhea I was experiencing. The only downside is the powdery texture, which makes it a bit difficult to take.

4.7Patient Review

6/20/2009

Questran Light for Chronic Diarrhea

I wish this were available in pill form. The daily dose is tough to consume otherwise.

4.7Patient Review

11/15/2009

Questran Light for Chronic Diarrhea

I'd been dealing with IBS for years by the time I saw a specialist in my senior year of high school. They prescribed me this medication, and it worked immediately. That was nine years ago, and I haven't had a single problem since. But now my doctor wants me to stop taking it before I try to get pregnant, and I'm honestly terrified that something will go wrong if I do. This drug has been a miracle for me, and I don't know if I can live without it.

4.7Patient Review

2/22/2011

Questran Light for Chronic Diarrhea

The taste isn't great, but it's not terrible either. It's more of a gritty texture that turns my stomach.

4Patient Review

10/6/2014

Questran Light for Chronic Diarrhea

After my intestinal surgery for Crohn's, this medication really helped to control my diarrhea.

3.3Patient Review

2/26/2009

Questran Light for Chronic Diarrhea

Questran Light was recommended to me by my doctor, and it has been an absolute godsend. If you suffer from chronic diarrhea, I urge you to give this medication a try.

3.3Patient Review

10/16/2018

Questran Light for Chronic Diarrhea

My stomach nerves were damaged during a hernia surgery, and ever since then I've had diarrhea 2-3 times per week. After taking Questran Lite for two weeks, I experienced perfect results; however, those good results have diminished over the past 6 weeks until now where I'm back at having dumping 2-3 times per week. Does anyone have any suggestions?

3Patient Review

1/11/2011

Questran Light for High Cholesterol

This medicine has been a godsend for me. I was originally misdiagnosed with IBS, but recently learned that I have Habba Syndrome, which is similar but caused by the overproduction of bile. This medication stops the reabsorption of bile and has completely alleviated my symptoms! The only downside is that the powder is very bitter and unpleasant to drink (even in Gatorade).

3Patient Review

7/16/2021

Questran Light for Chronic Diarrhea

I've only just started taking this medication and experienced terrible stomach pain on the first day. However, I will persevere as I suffer from chronic diarrhea which can have me running to the bathroom up to 20 times a day. I'm also very sensitive to food and medications, so I'll keep trying this treatment and let you know how it goes.

2.7Patient Review

6/14/2022

Questran Light for chronic diarrhea due to bile acid malabsorption

I've had to take this powder for years due to bile acid malabsorption, and it's incredibly unpleasant. It does help with the diarrhoea, but I feel like I can't stand to take it another day. I've heard there's a pill available in the UK called Colesevelam that has the same effect, but it's not available in Australia. I hope there's some way I can get my hands on it because Questran is absolutely terrible.

2.7Patient Review

2/19/2011

Questran Light for Chronic Diarrhea

I'm not sure if this will help me or not, but for those who want a pill form of the treatment, Welchol is available. I tried it last May for my hyperlipidemia and had to take six pills a day, which made me nauseous.

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about questran light

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Questran Light used for?

"This medicine helps to lower your body's cholesterol levels, which can reduce your risk of heart disease. It works by adsorbing bile acids containing cholesterol in the digestive system, which are then eliminated from the body in the faeces."

Answered by AI

What are the side effects of Questran Lite?

"The following effects may occur: constipation, stomach/abdominal pain, gas, nausea, or vomiting. If you experience any of these effects, tell your doctor or pharmacist."

Answered by AI

When should I take Questran?

"This medication is to be taken as prescribed by your doctor. The medication should be taken before a meal and/or at bedtime. Any other medications should be taken at least 1 hour before or 4 hours after you take cholestyramine to avoid interference with absorption."

Answered by AI

Is there an alternative to Questran Light?

"If questran & colesevelam are not available from your local pharmacies, colestipol granules (Brand name Cholestid) is the only alternative bile acid sequestrant available."

Answered by AI

Clinical Trials for Questran Light

Have you considered Questran Light clinical trials? We made a collection of clinical trials featuring Questran Light, we think they might fit your search criteria.

Have you considered Questran Light clinical trials? We made a collection of clinical trials featuring Questran Light, we think they might fit your search criteria.

Image of University of Maryland Amish Research Clinic in Lancaster, United States.

Direct Contact Genetic Screening for High Cholesterol

18+

All Sexes

Lancaster, PA

An important aspect of successful genomic medicine implementation is developing effective approaches for screening at-risk family members after probands are identified, also known as cascade screening. Most cascade screening studies conducted to date have been conducted outside the US, and very few studies have used a rigorous approach involving a comparator group or randomized controlled design. A major question in the field is how to most effectively implement cascade screening, given commonly cited communication barriers, while respecting privacy among probands and family members. This study will conduct a randomized controlled trial to assess direct contact of relatives by study team members vs indirect, or proband-initiated, contact. We will assess efficacy of the cascade screening intervention, patient-centered outcomes regarding mental, physical, and psychosocial outcomes in probands and family members, and implementation evaluation outcomes. Individuals who are known to carry the KCNQ1 Met224Thr or APOB Arg3527Gln variant will be eligible to participate. After providing consent and being deemed eligible, individuals will be randomized in a 1:1 manner into the direct or indirect contact of family members arm of the study. The randomization will be stratified by variant to ensure equal representation of each variant in the study arms. Individuals in the indirect arm will be instructed to contact their first-degree family members about the opportunity to be screened. They will be provided with a disease-specific pamphlet and a family letter explaining the cascade screening. In the direct arm, probands will be advised that the study staff will be contacting their family members. They will be instructed to also contact their family members prior to the study team contacting them. Approximately two weeks after this meeting with the proband, the study staff will mail letters to eligible first-degree family members of the probands. If we do not hear back from individual family members, we will follow-up with another letter, telephone call, or home visit. The information contained in the letters will be the same information for both the direct and indirect arms of the study. All interested family members will receive pre-test counseling and free, in-home, saliva-based genetic testing, and post-test counseling.

Recruiting

Has No Placebo

University of Maryland Amish Research Clinic

Have you considered Questran Light clinical trials? We made a collection of clinical trials featuring Questran Light, we think they might fit your search criteria.