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Air Filtration
Air Filtration for Heart Disease (SAPIA Trial)
N/A
Recruiting
Led By Zhanghua Chen, PhD
Research Sponsored by University of Southern California
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Age between 65 and 84 years old
Weight ≥ 110 pounds
Timeline
Screening 3 weeks
Treatment Varies
Follow Up at the baseline, in the middle (4.5 month after intervention) and immediately after each of the 9-month interventions
Awards & highlights
SAPIA Trial Summary
This trial tests if air filters can reduce air pollution for adults with heart disease, to slow down artery damage.
Who is the study for?
Adults aged 65-84 living in Los Angeles County with a history of ischemic heart disease, clinically stable for the past 6 months, and weighing at least 110 pounds can join. Smokers or those with certain health conditions like active cancer treatments or degenerative diseases are excluded.Check my eligibility
What is being tested?
The trial is testing if using HEPA air filters in homes can slow down the worsening of atherothrombosis (blood clotting in hardened arteries) compared to sham (fake) filters by reducing fine particle pollution indoors.See study design
What are the potential side effects?
Since this trial involves indoor air filtration systems, there are no direct medical side effects expected from participating. However, any unexpected reactions to the equipment will be monitored.
SAPIA Trial Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I am between 65 and 84 years old.
Select...
I weigh at least 110 pounds.
SAPIA Trial Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ at the baseline, in the middle (4.5 month after intervention) and immediately after each of the 9-month interventions
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~at the baseline, in the middle (4.5 month after intervention) and immediately after each of the 9-month interventions
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Change in P-selectin
Change in augmentation index
Change in blood pressure
+2 moreSecondary outcome measures
Change in C-reactive protein
Change in fasting glucose
Change in fasting insulin
+3 moreSAPIA Trial Design
2Treatment groups
Experimental Treatment
Group I: Sham first and HEPAExperimental Treatment2 Interventions
This group of participants will be assigned to the intervention of sham filtration with HEPA filter removed at their residence for 9 months first. After 3-month wash-out period, participants will be assigned to the HEPA filtration for 9 months.
Group II: HEPA first and shamExperimental Treatment2 Interventions
This group of participants will be assigned to the intervention of HEPA filtration with the capacity to reduce indoor PM2.5 levels at their residence for 9 months first. After 3-month wash-out period, participants will be assigned to sham filters (air purifier has the same appearance but HEPA filter is removed) for 9 months.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
HEPA filtration
2009
N/A
~50
Find a Location
Who is running the clinical trial?
University of Southern CaliforniaLead Sponsor
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1,596,064 Total Patients Enrolled
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Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- Your home cannot accommodate air purifiers and air pollution monitors.I have a degenerative nervous system condition like dementia or Alzheimer's.Your home already has HEPA filters.I am between 65 and 84 years old.I weigh at least 110 pounds.You haven't smoked for at least 1 year.I can communicate in either English or Spanish.My heart disease has been stable for 6 months without worsening symptoms.I will be living away from my primary home for over a month.You plan to change your home address within the next 2 years.I am currently undergoing treatment for cancer.
Research Study Groups:
This trial has the following groups:- Group 1: HEPA first and sham
- Group 2: Sham first and HEPA
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Is the advanced age range for this experiment limited to those above 75 years old?
"The requisites for entering this trial are that applicants must be between 65 and 84 years of age. There are 109 studies conducted with participants under 18, and 816 studies involving those older than 65."
Answered by AI
To what demographic is this research geared?
"Qualified candidates for this medical trial must have atherosclerosis and be within the ages of 65 to 84. It is expected that up to 112 patients will ultimately be admitted into the study."
Answered by AI
Is this research project currently accepting participants?
"According to information found on clinicaltrials.gov, this specific trial is not accepting participants at the moment. It was initially posted on May 1st 2023 and last updated two weeks later, yet it remains inactive. However, there are numerous other clinical trials actively recruiting patients currently with a total of 904 studies available for enrollment."
Answered by AI
What is the end goal of this medical experiment?
"The primary outcome of this nine-month study is to measure the alteration in carotid-femoral pulse wave velocity, with daily blood pressure readings taken during the intervention. Secondary outcomes include shifts in fasting insulin levels, alterations in lipid profiles (LDL, HDL, VLDL triglycerides and total cholesterol), as well as changes in C-reactive protein levels from baseline measurements."
Answered by AI
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