Ibuprofen & Acetaminophen vs Oxycodone for Postoperative Pain
Trial Summary
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications, but you cannot participate if you are currently using opioids.
What data supports the effectiveness of the drug combination of ibuprofen and acetaminophen for postoperative pain?
Research shows that combining ibuprofen and acetaminophen can provide more effective pain relief than using either drug alone, as seen in studies involving root canal treatment and orthopedic surgery. This combination offers enhanced pain control with fewer side effects compared to higher doses of a single drug.12345
Is the combination of ibuprofen, acetaminophen, and oxycodone safe for postoperative pain management?
Research suggests that combining ibuprofen and acetaminophen is generally safe and effective for pain relief, with common mild side effects like nausea and headache. Oxycodone combinations are also considered safe and effective, offering enhanced pain relief with a potentially improved side effect profile compared to using oxycodone alone.16789
How does the ibuprofen and acetaminophen combo drug differ from other drugs for postoperative pain?
What is the purpose of this trial?
In the US, pain management after surgery for surgical treatment of osteoarthritis at the base of the thumb typically consists of prescription opioids during the early recovery phase. Given the highly addictive nature of prescription opioids, guidelines are being evaluated by hand surgeons to reduce opioid use while still maintaining pain control after surgery. A promising approach is to use non-narcotic medication as the first line of treatment. The purpose of this study is to demonstrate the efficacy of a combination of non-steroidal anti-inflammatory drugs (NSAIDs), ibuprofen and acetaminophen, in comparison to a morphine analogue substance (oxycodone) for pain management in the first 30 days after surgery.
Research Team
Amy Ladd, MD
Principal Investigator
Stanford Orthopaedic Surgery
Eligibility Criteria
This trial is for English-speaking individuals undergoing trapeziectomy due to thumb osteoarthritis. It's not suitable for those with concurrent surgeries, liver/kidney issues, allergies to the study medications, pregnant women, people unable to complete forms due to various conditions, or patients with a history of heart failure, bleeding disorders or current opioid use.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive either NSAIDs (ibuprofen and acetaminophen) or opioids (oxycodone) for pain management after trapeziectomy surgery
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- NSAID capsules
- NSAID combo capsule
- Opioid capsule
NSAID combo capsule is already approved in United States, European Union, Canada for the following indications:
- Pain relief
- Fever reduction
- Inflammation
- Pain relief
- Fever reduction
- Inflammation
- Pain relief
- Fever reduction
- Inflammation
Find a Clinic Near You
Who Is Running the Clinical Trial?
Stanford University
Lead Sponsor