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Non-narcotic Analgesic

Ibuprofen & Acetaminophen vs Oxycodone for Postoperative Pain

Phase 2
Recruiting
Led By Amy Ladd, MD
Research Sponsored by Stanford University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Undergoing trapeziectomy for thumb osteoarthritis
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline, post-operative weeks 1, 3, 5, and 8
Awards & highlights

Study Summary

This trial found that a combination of over the counter NSAIDs was as effective as the prescription opioid oxycodone for pain management in the first month after surgery for thumb osteoarthritis.

Who is the study for?
This trial is for English-speaking individuals undergoing trapeziectomy due to thumb osteoarthritis. It's not suitable for those with concurrent surgeries, liver/kidney issues, allergies to the study medications, pregnant women, people unable to complete forms due to various conditions, or patients with a history of heart failure, bleeding disorders or current opioid use.Check my eligibility
What is being tested?
The study compares pain management strategies post-trapeziectomy: one group receives NSAIDs (ibuprofen and acetaminophen) while the other gets an opioid (oxycodone). The goal is to assess if non-narcotic meds can effectively manage pain without using opioids in the first month after surgery.See study design
What are the potential side effects?
NSAIDs may cause stomach upset, bleeding risks and kidney problems. Oxycodone can lead to constipation, nausea/vomiting, drowsiness and has a high risk of addiction.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am having surgery for thumb arthritis.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline, post-operative weeks 1, 3, 5, and 8
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, post-operative weeks 1, 3, 5, and 8 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Pain
Pain
Pharmaceutical Preparations
+1 more
Secondary outcome measures
Change in PROMIS-PI scores over time
Change in Quick DASH scores over time

Trial Design

2Treatment groups
Experimental Treatment
Group I: OpioidsExperimental Treatment1 Intervention
Following surgery will receive opioid capsules following surgery. Will take online and phone surveys.
Group II: NSAIDSExperimental Treatment1 Intervention
Following surgery will receive NSAID capsules following surgery. Will take online and phone surveys.

Find a Location

Who is running the clinical trial?

Stanford UniversityLead Sponsor
2,383 Previous Clinical Trials
17,333,683 Total Patients Enrolled
7 Trials studying Postoperative Pain
1,042 Patients Enrolled for Postoperative Pain
Amy Ladd, MDPrincipal InvestigatorStanford Orthopaedic Surgery

Media Library

NSAID combo capsule (Non-narcotic Analgesic) Clinical Trial Eligibility Overview. Trial Name: NCT04676802 — Phase 2
Postoperative Pain Research Study Groups: Opioids, NSAIDS
Postoperative Pain Clinical Trial 2023: NSAID combo capsule Highlights & Side Effects. Trial Name: NCT04676802 — Phase 2
NSAID combo capsule (Non-narcotic Analgesic) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04676802 — Phase 2

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

To what extent are NSAID capsules a hazard for people seeking treatment?

"Although no efficacy data has been gathered, there are safety studies in place for NSAID capsules. Therefore, the assessment of its safety received a rating of 2 out of 3."

Answered by AI

Are there available slots in this experiment for participants?

"According to the data hosted on clinicaltrials.gov, enrollment is still open and this trial has been actively recruiting since its inception on December 27th 2021. The most recent update was also posted on that same day."

Answered by AI

What is the size of this medical research project's cohort?

"Affirmative. According to clinicaltrials.gov, this medical trial has been actively recruiting since December 27th 2021 and just recently underwent its last update on the same day. The study is seeking 121 patients from 1 site."

Answered by AI
~52 spots leftby Feb 2026