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Meal Intake for Atherosclerosis (HPL Trial)

N/A

Waitlist Available

Led By Bettina Mittendorfer

Research Sponsored by University of Missouri-Columbia

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

18 years or older

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up change from before meal at 1 hour and 3 hours, compared to before

Awards & highlights

HPL Trial Summary

This trial looks at the effects of different types of liquid meals on the body's cells.

Who is the study for?

This trial is for adults who can consume milk-based liquid meals. It's not suitable for those with a history of organ transplant, diabetes, heart disease, high blood pressure, stroke or cancer. Pregnant individuals and those allergic to meal ingredients or on certain medications like Rapamycin/Sirolimus and statins cannot participate.Check my eligibility

What is being tested?

The study tests the effects of different protein levels in meals on cardiovascular risk factors. Participants will receive one of three types of liquid meals: low protein, high protein, or low protein with added leucine (which activates mTOR signaling). Blood samples will be taken before and after meal consumption to analyze monocyte and platelet activation.See study design

What are the potential side effects?

Since this trial involves dietary intake rather than drugs, side effects may include digestive discomfort related to the liquid meals consumed. However, specific side effects are not detailed as they depend on individual reactions to diet changes.

HPL Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I am 18 years old or older.

HPL Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ change from before meal at 1 hour and 3 hours, compared to before

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~change from before meal at 1 hour and 3 hours, compared to before

This trial's timeline: 3 weeks for screening, Varies for treatment, and change from before meal at 1 hour and 3 hours, compared to before for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

p-mTOR in monocytes

HPL Trial Design

3Treatment groups

Active Control

Group I: Standard protein mealActive Control1 Intervention

Participants will receive a standard protein meal, containing about 10% of energy as protein

Group II: High protein mealActive Control1 Intervention

Participants will receive a high protein meal, containing about 50% of energy as protein

Group III: Low protein meal + leucineActive Control1 Intervention

Participants will receive a standard protein meal, containing about 10% of energy as protein to which leucine has been added to match the total leucine content of the high protein meal

0 / 1Eligibility criteria met

Find a Location

Who is running the clinical trial?

University of Missouri-ColumbiaLead Sponsor

362 Previous Clinical Trials

628,109 Total Patients Enrolled

2 Trials studying Atherosclerosis

24 Patients Enrolled for Atherosclerosis

Washington University School of MedicineOTHER

1,940 Previous Clinical Trials

2,303,385 Total Patients Enrolled

7 Trials studying Atherosclerosis

3,673 Patients Enrolled for Atherosclerosis

Bettina MittendorferPrincipal InvestigatorUniversity of Missouri-Columbia

5 Previous Clinical Trials

274 Total Patients Enrolled

1 Trials studying Atherosclerosis

24 Patients Enrolled for Atherosclerosis

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Would seniors be eligible for the current clinical experiment?

"In order to participate in this clinical trial, the patient must have reached their 18th birthday but be no older than 95."

Answered by AI

How many individuals are currently participating in this experiment?

"Indeed, clinicaltrials.gov furnishes information which shows that this medical experiment is currently recruiting volunteers. It was initiated on July 12th 2022 and underwent its most recent amendment on the 20th of the same month. Only 10 persons are being sought from a single site for this study."

Answered by AI

What sort of requirements must a participant meet to join this experiment?

"Qualified individuals who are between 18 and 95 years old, suffering from atherogenesis, may enroll in this trial. Enrollment is currently open for approximately 10 participants."

Answered by AI

Is the enrollment period still open for participants in this experiment?

"According to clinicialtrials.gov, this scientific inquiry is actively recruiting candidates. Its details were first made available on July 12th 2022 and had its most recent update on the 20th of that same month."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Leucine, mTOR and Athero

Bettina Mittendorfer 2022. "Leucine, mTOR and Athero". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05470218.

All > Atherosclerosis