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Procedure

UHR-CT (Ultra-High-Resolution Computed Tomography-Aquilion Precision) for Coronary Heart Disease

N/A

Recruiting

Led By Joao Lima, Professor

Research Sponsored by Johns Hopkins University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Patients aged 21-85 years

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up up to 24 months

Awards & highlights

Study Summary

This trial will compare UHR-CT and conventional resolution CT for diagnosis of coronary heart disease. UHR-CT has higher radiation exposure and longer scan times, so it's important to study if it's worth using.

Who is the study for?

This trial is for individuals with various forms of heart disease, including coronary artery disease and myocardial ischemia. Participants should be generally at lower risk to assess the effectiveness of a new Ultra High-Resolution CT scan compared to conventional CT scans.Check my eligibility

What is being tested?

The CORE-COMPARE study is testing whether an advanced scanning technology called Ultra High-Resolution Computed Tomography (UHR-CT) can better identify blockages in the heart's arteries than standard CT scans without exposing patients to additional scans.See study design

What are the potential side effects?

Potential side effects may include exposure to higher levels of radiation than conventional CT scans, which could increase cancer risk over time. Longer scan times might also cause discomfort or inconvenience for some patients.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I am between 21 and 85 years old.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ up to 24 months

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~up to 24 months

This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 24 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

agreement between the number of patients with >70% stenosis detected by ultra-high-resolution tomography compared to conventional tomography, with catheterization considered as the gold standard.

Secondary outcome measures

Assessment of vascular and plaque metrics

Diagnostic Confidence Assessment

Interobserver Variability Analysis

+2 more

Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: UHR-CT (Ultra-High-Resolution Computed Tomography-Aquilion Precision)Experimental Treatment1 Intervention

Participants in this arm undergo CT scans using the Ultra-High-Resolution CT imaging modality.

Group II: CR-CT (Conventional Resolution Computed Tomography)Active Control1 Intervention

Participants in this arm receive CT scans using the Conventional Resolution CT imaging modality.

0 / 1Eligibility criteria met

Find a Location

Who is running the clinical trial?

Johns Hopkins UniversityLead Sponsor

2,266 Previous Clinical Trials

14,837,357 Total Patients Enrolled

Canon Medical Systems, USAIndustry Sponsor

9 Previous Clinical Trials

654 Total Patients Enrolled

Joao Lima, ProfessorPrincipal InvestigatorMD

1 Previous Clinical Trials

10 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is it possible for me to join this trial?

"Eligible candidates must have coronary heart disease and be between 21 and 85 years old to join this trial. Overall, 140 individuals will receive acceptance into the study."

Answered by AI

Does this medical study permit enrollees younger than 40 years of age?

"For this medical trial, those aged 21 to 85 will be considered for participation. In comparison, there are 111 trials available for minors and 697 studies dedicated to elderly individuals."

Answered by AI

Is this trial currently accepting new participants?

"Affirmative. The clinicaltrials.gov platform states that this study is open for registration, having been initially listed on April 5th 2021 and most recently updated on December 5th 2023. 140 participants are required at a single site to complete the trial."

Answered by AI

What is the highest number of participants enrolled in this experiment?

"Affirmative, this clinical trial is actively seeking participants. According to the information posted on clinicaltrials.gov, it was initially uploaded on April 5th 2021 and recently updated December 5th 2023. 140 patients are required from a single medical centre."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

CORE-COMPARE Pilot Study

2021. "CORE-COMPARE Pilot Study". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT06170541.