Your session is about to expire
← Back to Search
Apalutamide + SBRT for Prostate Cancer (PILLAR Trial)
PILLAR Trial Summary
This trial is testing apalutamide with or without radiation therapy to see if it can effectively treat prostate cancer that is no longer responding to hormone therapy.
PILLAR Trial Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowPILLAR Trial Timeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.PILLAR Trial Design
Find a Location
Who is running the clinical trial?
Media Library
- I have or am at risk of having spinal cord compression.I have stopped taking certain medications and treatments that could affect the trial results.I haven't had serious heart issues or blood clots in the last 6 months.I have cancer other than skin or superficial bladder cancer that needs treatment.I am older than 18 years.My high blood pressure is under control with medication.I do not have conditions like inflammatory bowel disease that make radiation unsafe for me.My prostate cancer was confirmed by a lab test.My prostate cancer is worsening despite hormone therapy, with rising PSA levels.I have 1 to 5 areas of cancer that can be targeted with radiation, as seen on a special scan.I haven't received any systemic treatment for castration-resistant prostate cancer.I have been on a stable dose of medication for bone loss for at least 4 weeks.I've stopped my first anti-androgen treatment 6 weeks ago and my prostate cancer is still getting worse.It's been over 4 weeks or 5 half-lives since my last cancer treatment, excluding LHRH analog or first-generation antiandrogen.It has been over 4 weeks since my last major surgery or radiation therapy.I have a history of seizures or conditions that could lead to seizures.I am castrated with low testosterone levels and have been on continuous hormone therapy if medically castrated.All side effects from my previous treatments have mostly gone away.My hemoglobin level is at least 9.0 g/dL without needing transfusions or growth factors in the last 3 months.I am fully active or restricted in physically strenuous activity but can do light work.I am willing and able to follow the study's schedule and procedures, including taking pills.I have cancer that has spread to my lungs or liver, or I need radiation for bone cancer.My kidney function is good, with a filtration rate of at least 45 ml/min.I have a digestive condition that affects how my body absorbs food.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
- All Individual Drugs Already Approved - Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Group 1: Arm I (apalutamide, SBRT)
- Group 2: Arm II (SBRT)
Frequently Asked Questions
Is this an innovative or revolutionary clinical trial?
"Since 2014, Aragon Pharmaceuticals have sponsored research into Stereotactic Body Radiation Therapy. Following a successful trial involving 982 people in that year, the drug received Phase 3 approval. Currently there are 44 active clinical trials for this therapy being conducted across 552 cities and 38 countries worldwide."
Is Stereotactic Body Radiation Therapy licensed by the FDA?
"Our assessment at Power assigned Stereotactic Body Radiation Therapy a score of 2, signifying there is evidence for its safety but not yet enough for efficacy."
Is there still an opportunity to join this clinical research?
"Affirmative. Information from clinicaltrials.gov reveals that this trial, first posted on December 17th 2019, is currently recruiting participants. Approximately 60 individuals are needed at 1 medical centre to take part in the research."
What has been the experience with Stereotactic Body Radiation Therapy in previous experiments?
"Presently, 44 trials for Stereotactic Body Radiation Therapy are in progress with 15 of those Phase 3. The majority of these tests take place at a single site in South Weymouth, Massachusetts; however, there are 2417 other locations running studies related to this therapy."
To what extent is participant recruitment for this clinical trial progressing?
"Affirmative. According to clinicaltrials.gov, this medical experiment is actively enrolling participants; it was first posted on December 17th 2019 and its most recent modification took place on August 29th 2022. Sixty individuals need to be recruited from a single site for the study's completion."
Share this study with friends
Copy Link
Messenger