Tempol for Treatment Toxicities
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests Tempol in head and neck cancer patients to see if it can reduce side effects from radiation and chemotherapy. Tempol protects healthy cells but not cancer cells, potentially reducing issues like mouth sores, kidney damage, and hearing loss.
Will I have to stop taking my current medications?
The trial requires that you stop taking certain medications, such as non-approved therapies for oral mucositis, specific mouthwashes, and some other drugs, at least 14 days before starting the treatment. If you are on any of these, you will need to stop them before participating.
How does the drug Tempol differ from other treatments for treatment toxicities?
Tempol is unique because it is being studied for its potential to reduce treatment-related toxicities, which may not be the primary focus of other treatments. While the research does not provide direct information about Tempol, it highlights the importance of considering excipients (inactive ingredients) in medications, which can sometimes cause side effects. This suggests that Tempol might be formulated to minimize such issues, making it potentially safer or more tolerable compared to other treatments.12345
What data supports the effectiveness of the drug Tempol for treatment toxicities?
Who Is on the Research Team?
Benji Crane
Principal Investigator
Matrix Biomed, Inc.
Are You a Good Fit for This Trial?
This trial is for adults over 18 with squamous cell cancer of the head and neck, undergoing cisplatin chemotherapy and radiotherapy. They must have good kidney function, not be pregnant or breastfeeding, use effective birth control if applicable, and not have a history of certain conditions like HIV or insulin-dependent diabetes.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive either 1000 mg Tempol or placebo daily during radiation treatment
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Placebo Solution
- Tempol
Find a Clinic Near You
Who Is Running the Clinical Trial?
Matrix Biomed, Inc.
Lead Sponsor