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Neoadjuvant Atezolizumab for Melanoma
Study Summary
This trial will test whether using atezolizumab before surgery is safe and does not cause side effects that would delay the surgery.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Side effects data
From 2019 Phase 3 trial • 1225 Patients • NCT02008227Trial Design
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Who is running the clinical trial?
Media Library
- My skin cancer is confirmed and still present after initial treatment.I have or had an autoimmune disease or immune deficiency.I have not had major surgery in the last 4 weeks.I have had a previous transplant of stem cells or an organ.I haven't taken any immune-boosting drugs in the last 4 weeks or 5 half-lives of the drug.I have high calcium levels in my blood that are causing symptoms.I have active tuberculosis.My blood and organs are functioning well.I haven't had cancer in the last 2 years, except for certain skin cancers or cervical cancer that was treated.I do not have HIV, or if I do, it is under control with treatment.I have not received a live vaccine in the last 4 weeks and do not plan to during or within 5 months after the trial.You are allergic to Chinese hamster ovary cell products or any part of atezolizumab.I haven't taken any antibiotics in the last 2 weeks.I have not received any treatment for my condition.My doctor believes my cancer can be surgically removed completely.You tested negative for hepatitis B surface antigen before joining the study.I haven't taken any immune-weakening drugs in the last 2 weeks.I don't have any health issues that would make it unsafe for me to take a new drug.I have had cancer spread to the lining of my brain and spinal cord.I am currently on medication for hepatitis B.I am either female or male.My cancer has not spread beyond its original site.I am currently taking blood thinners at treatment doses.My breast cancer is at an early but high-risk stage according to specific guidelines.My melanoma is located in a specific area such as the anus, vagina, mucosa, or soft parts.I am 18 years old or older.I frequently need procedures to remove excess fluid from my body.I have a history of specific lung conditions not caused by known factors.I have previously been treated with specific immune therapies.I have not had a severe infection or been hospitalized for one in the last 4 weeks.I haven't had major heart problems or strokes in the last 3 months.I can take care of myself and perform daily activities.You have had serious allergic reactions to certain types of medications in the past.
- Group 1: Atezolizumab
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Is this an unprecedented exploration of the subject matter?
"Investigations into Atezolizumab began in 2008, when Hoffmann-La Roche sponsored a clinical trial of 720 participants. This initial study resulted in Phase 2 approval for the drug. At present, 350 active trials of this medication are taking place across 74 nations and 1646 cities."
What is the magnitude of participants in this scientific investigation?
"Affirmative. Clinicaltrials.gov reveals that this research is presently enlisting volunteers, with the first post appearing on September 25th of 2020 and an update happening December 28th 2021. Twenty individuals are needed for trial participation from a single site."
Has the FDA provided authorization for Atezolizumab?
"The safety of Atezolizumab was assigned a rating of 1 due to its research status as a Phase 1 trial, implying that there is limited evidence for both efficacy and security."
Are there still opportunities to participate in this medical experiment?
"Affirmative, the data hosted on clinicaltrials.gov reveals that this trial is actively seeking volunteers since it was initially published in September 25th 2020 and has been recently updated on December 28th 2021. The study requires a total of 20 participants to be recruited across 1 medical centre."
What maladies has Atezolizumab been demonstrated to alleviate?
"Atezolizumab can be employed to combat small cell lung cancer, malignant neoplasms, and non-small cell carcinoma."
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