Tranexamic Acid for Reducing Bruising After Dermal Filler
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests tranexamic acid (TXA) to determine its effectiveness in reducing bruising, swelling, and pain after facial fillers. The study compares the effects of TXA with standard facial fillers on different sides of the face. It suits individuals planning to get facial fillers who wish to see if TXA can ease recovery. Participants should be interested in facial fillers and have no history of blood clots or current smoking habits. As a Phase 2 trial, this research measures TXA's effectiveness in an initial, smaller group, allowing participants to contribute to important findings.
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications, but you cannot participate if you are using estrogen, therapeutic anticoagulation therapy, or aspirin.
Is there any evidence suggesting that tranexamic acid is likely to be safe for humans?
Research has shown that tranexamic acid (TXA) is generally safe. It has been used safely in facial surgeries to reduce bruising and swelling. One study found that administering TXA before surgery significantly reduced bruising. Another study confirmed that TXA is safe and improves outcomes in facial procedures. TXA has been used safely for many years in various surgeries, indicating it is well-tolerated. While researchers continue to study its use with facial fillers, its past use in similar treatments suggests it is safe.12345
Why do researchers think this study treatment might be promising?
Most treatments for bruising after dermal fillers involve topical creams or manual techniques to minimize bruising and swelling. But Tranexamic Acid (TXA) works differently. Unlike these standard care methods, TXA is an antifibrinolytic agent, which means it helps prevent the breakdown of blood clots. This unique action can potentially reduce bruising by stabilizing blood vessels and preventing excessive bleeding under the skin. Researchers are excited about TXA because it might offer a more effective and immediate solution to post-filler bruising, providing quicker recovery and better cosmetic outcomes for patients.
What evidence suggests that tranexamic acid might be an effective treatment for reducing bruising after dermal filler?
Research has shown that tranexamic acid (TXA) can reduce bruising after facial procedures. TXA prevents blood clots from breaking down too quickly, which may limit bleeding under the skin and reduce bruising and swelling. In this trial, participants will receive TXA plus HA injection on one half of the face and saline plus HA injection on the other half to evaluate its specific effectiveness in reducing bruising after dermal filler injections. While TXA is commonly used in facial plastic surgery, early results from other cosmetic procedures suggest it might be helpful, but more research is needed to confirm these effects for fillers.34678
Who Is on the Research Team?
Daniel Cho, MD, PhD
Principal Investigator
University of Wisconsin, Madison
Are You a Good Fit for This Trial?
This trial is for individuals seeking facial filler injections and willing to participate in surveys. The study specifically includes those who are suitable candidates for dermal fillers with hyaluronic acid. Details on exclusion criteria were not provided, so it's important to contact the trial organizers for more information.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive facial filler injections with HA on one half of the face and HA+TXA on the other half
Follow-up
Participants are monitored for swelling, bruising, pain, and satisfaction through surveys and medical record reviews
What Are the Treatments Tested in This Trial?
Interventions
- Tranexamic Acid
Tranexamic Acid is already approved in United States, European Union, Canada, Japan for the following indications:
- Heavy menstrual bleeding
- Prevention of excessive bleeding during surgeries
- Heavy menstrual bleeding
- Prevention of excessive bleeding during surgeries
- Hereditary angioedema
- Heavy menstrual bleeding
- Prevention of excessive bleeding during surgeries
- Heavy menstrual bleeding
- Prevention of excessive bleeding during surgeries
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Wisconsin, Madison
Lead Sponsor