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Behavioral Intervention

Resistance Training vs. Interval Training for Muscle Endurance (LLSIT Trial)

N/A

Recruiting

Research Sponsored by University of British Columbia

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be between 18 and 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up change from baseline to 12 weeks

Awards & highlights

LLSIT Trial Summary

This trial is testing if lifting weights or doing interval aerobic exercise helps improve muscle endurance. #exercise #muscleendurance

Who is the study for?

This trial is for healthy, English-speaking adults aged 19-30 who haven't done structured exercise training in the past year. It's not for those with a BMI outside of 18-30, smokers, or people with uncontrolled health issues like heart disease or diabetes.Check my eligibility

What is being tested?

The study compares two types of workouts to see which is better at improving muscle endurance: lifting lighter weights many times (LLRET) and high-intensity interval training (HIIT). Participants will be assigned to one workout type to measure changes in their muscles.See study design

What are the potential side effects?

Since this trial involves physical exercise, potential side effects may include muscle soreness, fatigue, and risk of injury. The intensity of these side effects can vary based on individual fitness levels and adherence to proper technique.

LLSIT Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ change from baseline to 12 weeks

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~change from baseline to 12 weeks

This trial's timeline: 3 weeks for screening, Varies for treatment, and change from baseline to 12 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Change in CFPE index (Capillary to fiber ratio normalized to fiber perimeter)

Change in Maximal Citrate synthase (CS) Activity

Change in Repetitions completed for 30% pre-training 1- Repetition maximum (Single leg Knee extension)

+1 more

Secondary outcome measures

Change in Capillary to fiber ratio (C/FI)

Change in Leg lean mass

Change in Single leg Knee Extension Isokentic Maximum Voluntary Contraction

+8 more

LLSIT Trial Design

2Treatment groups

Experimental Treatment

Group I: Sprint/High Intensity Interval TrainingExperimental Treatment1 Intervention

SIT/HIIT- 12 weeks (2-3 times/week), mix of SIT and HIIT (8-15 sets/session). SIT -30 second Super Maximal "Wingate style intervals" performed on a Kicking ergometer (single leg) with 4 minutes rest provided between sets (number of interval ranges from 4-5), load determined from DEXA leg lean mass and will not be altered throughout training. HIIT - 1-minute Submaximal efforts (90% single leg kicking ergometer VO2Peak Wattage) performed on a kicking ergometer (single leg) with 1 minute rest provided between sets (number of interval ranges from 8-10), if all sets completed wattage will be increased by 5watts for the next training session.

Group II: Low Load Resistance TrainingExperimental Treatment1 Intervention

LLRET - 12 weeks (2-3 times/week) 3 sets of Knee extension exercise (single leg) done at 30%1- RM. Performed to failure with 3 minutes of rest between sets, weight lifted will be adjusted throughout the study to keep repetitions completed in a 20-30 repetition range.

Do I qualify?Apply below to find out

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Who is running the clinical trial?

University of British ColumbiaLead Sponsor

1,413 Previous Clinical Trials

2,466,941 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does this trial have an age cutoff and, if so, is it inclusive of those over fifty?

"For enrollment in this research project, individuals must be aged between 19 years and 30 years."

Answered by AI

What demographic is eligible to join this research endeavor?

"To be accepted into this research initiative, volunteers must display symptoms of enlargement and possess an age between 19 to 30 years old. This trial is currently searching for roughly 20 participants."

Answered by AI

Is recruitment still happening for this experiment?

"Affirmative. The information available on clinicaltrials.gov verifies that this scientific investigation is actively recruiting participants, with the original posting dating back to September 27th 2023 and the most recent edit taking place on October 4th of 2023. In total, there are currently openings for twenty patients at a single medical facility."

Answered by AI

How many subjects are involved in this research study?

"Affirmative, the details on clinicaltrials.gov show that this trial is currently recruiting patients. It was first published on September 27th 2023 and most recently updated October 4th 2023. The medical study requires approximately 20 participants from one site to participate."

Answered by AI

What are the expected outcomes of this clinical experiment?

"This examination, measured over a span of 12 weeks, targets an increase in the capillary to fiber ratio normalized to fiber perimeter (CFPE index). Secondary goals include increases in single leg knee extension isokinetic maximum voluntary contraction force production at 60 degrees/second (assessed via Biodex), single leg knee extension isometric MVC power output at 90° flexion angle (measured by utilizing Biodex), and single leg knee flexion isometric MVC strength generated when bent 90° (evaluated with help from Biodex)."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Effect of Low-load Resistance Training vs. High-intensity Interval Training on Local Muscle Endurance

Cameron Mitchell 2023. "Effect of Low-load Resistance Training vs. High-intensity Interval Training on Local Muscle Endurance". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05945641.