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EHR Alert for Sepsis (PRECISE Trial)

N/A

Waitlist Available

Led By Sivasubramanium Bhavani, MD

Research Sponsored by Emory University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 30 days

Awards & highlights

PRECISE Trial Summary

This trial is trying to determine whether giving patients with sepsis balanced crystalloids instead of normal saline can improve their chances of survival. The researchers have developed a method to identify patients who may benefit

Who is the study for?

This trial is for adult patients in the emergency department who are suspected of having sepsis, as indicated by a blood culture order, and fall into a specific group (Group D) identified by an algorithm using vital signs. There are no exclusion criteria specified.Check my eligibility

What is being tested?

The study tests whether an algorithm can help doctors decide when to use balanced crystalloids instead of normal saline for treating sepsis. Patients in Group D will be randomly chosen to either receive this new approach or continue with standard care.See study design

What are the potential side effects?

Since both interventions involve commonly used IV fluids (normal saline and balanced crystalloids), side effects may include fluid overload, electrolyte imbalances, or reactions at the infusion site.

PRECISE Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 30 days

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~30 days

This trial's timeline: 3 weeks for screening, Varies for treatment, and 30 days for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Thirty-day mortality

Secondary outcome measures

In-hospital mortality

Intensive care unit (ICU) mortality

Mechanical ventilation

+2 more

PRECISE Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: EHR AlertExperimental Treatment1 Intervention

Enrolled patients who are classified to Group D by the algorithm will be randomized within the electronic health record to the intervention arm.

Group II: Standard of CareActive Control1 Intervention

Enrolled patients who are classified to Group D by the algorithm will be randomized within the electronic health record to usual care.

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

Emory UniversityLead Sponsor

1,641 Previous Clinical Trials

2,560,787 Total Patients Enrolled

13 Trials studying Sepsis

10,132 Patients Enrolled for Sepsis

Sivasubramanium Bhavani, MDPrincipal InvestigatorEmory University

2 Previous Clinical Trials

2,400 Total Patients Enrolled

2 Trials studying Sepsis

2,400 Patients Enrolled for Sepsis

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is the enrollment for this clinical trial currently open?

"According to the details listed on clinicaltrials.gov, recruitment for this research project is presently closed. The trial was made public on May 1st, 2024 and last revised on February 2nd, 2024. Despite this specific study no longer accepting participants, there are numerous other trials with a total of 191 ongoing opportunities available for potential candidates currently."

Answered by AI

Are multiple sites conducting this medical study in North America?

"At present, patient enrollment is ongoing at 7 diverse locations including Atlanta, Decatur, and Johns Creek among others. Opting for a site in close proximity can reduce the burden of travel when participating in this trial."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Precision Resuscitation With Crystalloids in Sepsis

Siva Bhavani 2024. "Precision Resuscitation With Crystalloids in Sepsis". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT06253585.

All > Sepsis