Absorbable vs Nonabsorbable Sutures for Cuts
What You Need to Know Before You Apply
What is the purpose of this trial?
This will be a prospective, randomized controlled trial assessing noninferiority of Vicryl Rapide compared to nonabsorbable suture. The study will be conducted in the Community Regional Medical Center emergency department (ED). The aim of this study, then, is to prospectively determine if 3-month cosmesis for traumatic laceration repair of trunk/extremity lacerations in adult patients with Vicryl Rapide is noninferior to nonabsorbable suture.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications.
Is it safe to use absorbable sutures like Vicryl Rapide in humans?
Vicryl Rapide (Polyglactin 910) is generally considered safe for use in humans, with studies showing it maintains wound closure effectively and causes little tissue reaction. It is used in various surgeries, including skin and corneal surgeries, and is absorbed by the body within weeks, reducing the need for suture removal.12345
How does the treatment Vicryl Rapide differ from other treatments for cuts?
What data supports the effectiveness of the treatment Vicryl Rapide, Coated VICRYL RAPIDE, Polyglactin 910 for cuts?
Research shows that Vicryl Rapide sutures are effective for skin closure, especially in children, as they absorb quickly and reduce complications compared to regular Vicryl sutures. Additionally, they maintain adequate wound closure with minimal tissue reaction, making them suitable for various surgical applications.24568
Who Is on the Research Team?
Brian Chinnock, MD
Principal Investigator
University of California, San Francisco
Are You a Good Fit for This Trial?
Adults over 18 with a single laceration longer than 2 cm on the trunk or extremity that can be closed with simple stitches. Excluded are those with wound healing issues, mental incapacity to consent, non-English/Spanish speakers, no reliable contact info, multiple lacerations needing sutures in the same area, and wounds at high risk of infection or poor healing.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Suture closure with either Vicryl Rapide or nonabsorbable suture according to randomization
Follow-up
Participants receive a follow-up call to assess complications and chart review for any ED revisits
Three-month Follow-up
Participants have a follow-up visit for wound photography and cosmesis evaluation
What Are the Treatments Tested in This Trial?
Interventions
- Vicryl Rapide
Vicryl Rapide is already approved in United States, European Union for the following indications:
- Superficial soft tissue approximation of the skin and mucosa where only short-term wound support (7-10 days) is required
- Skin closure, cuticular or subcuticular
- Episiotomies
- Closure of oral mucosa
- Conjunctival sutures in ophthalmic surgery
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of California, San Francisco
Lead Sponsor
Central California Faculty Medical Group
Collaborator