IV Saline for POTS
What You Need to Know Before You Apply
What is the purpose of this trial?
The investigators will test whether an intravenous infusion of saline (salt water) will improve the exercise capacity in patients with postural tachycardia syndrome (POTS).
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications, but it excludes those with medical conditions explained by medications. It's best to discuss your specific medications with the trial team.
Is IV saline generally safe for humans?
IV saline, specifically 0.9% sodium chloride, can cause issues like hyperchloremic acidosis (an imbalance in blood acidity) and may affect kidney function, especially in surgical or critically ill patients. However, these effects are more pronounced with high chloride content solutions, and balanced solutions with lower chloride levels are often recommended for safety.12345
How does saline treatment for POTS differ from other treatments?
Saline (normal saline, 0.9% sodium chloride) is unique for POTS (Postural Orthostatic Tachycardia Syndrome) as it is administered intravenously to quickly expand blood volume, which can help alleviate symptoms like dizziness and rapid heartbeat. Unlike other treatments that may focus on medication or lifestyle changes, saline directly increases blood volume, providing immediate relief.678910
What data supports the effectiveness of the treatment Normal Saline for POTS?
Research suggests that while saline is commonly used as an intravenous fluid, it may cause issues like kidney injury and metabolic acidosis. However, in some cases, sodium chloride solutions have been effective in treating conditions like hyponatremia by increasing sodium levels in the blood.68111213
Who Is on the Research Team?
Satish R Raj, MD MSCI
Principal Investigator
Vanderbilt University
Are You a Good Fit for This Trial?
This trial is for adults aged 18-65 who have been diagnosed with Postural Tachycardia Syndrome (POTS) and can consent to participate. It's not suitable for pregnant individuals, those with conditions that cause rapid heartbeat due to other reasons like dehydration or medications, or if they are bedridden/chair-ridden.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive an intravenous infusion of saline or placebo before exercise tests
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Placebo
- Saline
Saline is already approved in United States, European Union, Canada for the following indications:
Find a Clinic Near You
Who Is Running the Clinical Trial?
Vanderbilt University Medical Center
Lead Sponsor