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Proton Beam Therapy

Proton Therapy for Small Cell Lung Cancer

N/A
Recruiting
Led By Kristin Higgins, MD
Research Sponsored by Emory University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Age 18 or greater
Patients who are offered thoracic radiotherapy with intensity-modulated proton therapy (IMPT) techniques delivering 30-66 Gy in 15-33 fractions at 2 Gy per fraction, at the recommendation of the treating radiation oncologist
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 1,2, and 5 years
Awards & highlights

Study Summary

This trial tests a new way to treat small cell lung cancer using proton therapy. The goal is to see if it is safe and effective.

Who is the study for?
This trial is for adults over 18 with small cell lung cancer (SCLC), either limited or extensive stage, who are recommended to undergo thoracic radiotherapy using intensity-modulated proton therapy (IMPT) delivering specific doses. Pregnant individuals or those who have had prior radiation that overlaps with the target area cannot participate.Check my eligibility
What is being tested?
The study is examining the safety and effectiveness of a type of targeted radiation called intensity-modulated proton therapy (IMPT) in treating patients with small cell lung cancer. The IMPT will be administered in specified doses and number of sessions.See study design
What are the potential side effects?
Potential side effects from IMPT may include skin reactions, fatigue, difficulty swallowing, shortness of breath, coughing, and other localized symptoms due to the precise nature of proton beam targeting.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am 18 years old or older.
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I am recommended to undergo a specific type of chest radiation therapy.
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My lung cancer is confirmed to be small cell type.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 1,2, and 5 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 1,2, and 5 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Determination of the optimal frequency of conebeam CT during treatment and subsequent need for adaptive re-planning
Patients with small cell lung cancer (SCLC) will be assessed with the intensity-modulated proton therapy (IMPT).

Trial Design

1Treatment groups
Experimental Treatment
Group I: Prospective Study of Intensity-Modulated Proton Therapy (IMPT)Experimental Treatment1 Intervention
This is the first prospective study to investigate the safety and efficacy of IMPT for the treatment of SCLC. We will utilize adaptive planning throughout the radiation course. In addition, we will study the dosimetric parameters of IMPT and their correlation with treatment-related toxicities, particularly cardiac events.

Find a Location

Who is running the clinical trial?

Emory UniversityLead Sponsor
1,640 Previous Clinical Trials
2,560,666 Total Patients Enrolled
Kristin Higgins, MDPrincipal Investigator - Emory University-Winship Cancer Institute
Emory Saint Joseph's, Emory University Hospital, Emory University Hospital Midtown, Grady Memorial Hospital
Tulane University School Of Medicine (Medical School)
4 Previous Clinical Trials
81 Total Patients Enrolled

Media Library

Intensity-Modulated Proton Therapy (IMPT) (Proton Beam Therapy) Clinical Trial Eligibility Overview. Trial Name: NCT04342429 — N/A
Small Cell Lung Cancer Research Study Groups: Prospective Study of Intensity-Modulated Proton Therapy (IMPT)
Small Cell Lung Cancer Clinical Trial 2023: Intensity-Modulated Proton Therapy (IMPT) Highlights & Side Effects. Trial Name: NCT04342429 — N/A
Intensity-Modulated Proton Therapy (IMPT) (Proton Beam Therapy) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04342429 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is this medical experiment in need of participants at the moment?

"Affirmative. According to clinicaltrials.gov, this experiment has been open for recruitment since March 19th 2020 and the details were last updated on February 18th 2022. There is an urgent need for 30 participants at a single site."

Answered by AI

What is the upper limit for enrollment in this medical research endeavor?

"Affirmative, the facts hosted on clinicaltrials.gov shows that this medical experiment is presently accepting applicants. The trial was first published on March 19th 2020 and edited for the last time on February 18th 2022. This study will require 30 participants from 1 location to be recruited."

Answered by AI

Who else is applying?

What site did they apply to?
Winship Cancer Institute
What portion of applicants met pre-screening criteria?
Did not meet criteria
Recent research and studies
clinicaltrials.govStudy
Prospective Study of Intensity-Modulated Proton Therapy (IMPT) for Small Cell Lung Cancer
Sibo Tian 2020. "Prospective Study of Intensity-Modulated Proton Therapy (IMPT) for Small Cell Lung Cancer". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04342429.
~6 spots leftby May 2025
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