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Proton Beam Therapy

Proton Therapy for Chordoma and Chondrosarcoma

N/A
Waitlist Available
Research Sponsored by Abramson Cancer Center at Penn Medicine
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Age ≥ 18 years
Histologically confirmed diagnosis of chordoma or chondrosarcoma
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 90 days
Awards & highlights

Study Summary

This trial is testing whether proton therapy is a safe and effective treatment for chordomas and chondrosarcomas.

Who is the study for?
This trial is for adults (18+) with confirmed chordoma or chondrosarcoma in the skull and spine, without metastatic disease. Participants must be fairly active (ECOG ≤2), have good bone marrow function, and not be pregnant. They can't join if they've had other cancers in the last two years or are on another treatment study.Check my eligibility
What is being tested?
The study tests proton therapy's feasibility and immediate side effects for treating chordomas and chondrosarcomas, as well as its effectiveness and long-term side effects over time.See study design
What are the potential side effects?
While specific side effects aren't listed here, proton therapy may include skin reactions at the treatment site, fatigue, headaches, hair loss near treated areas, nausea or hearing changes depending on tumor location.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am 18 years old or older.
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My diagnosis is either chordoma or chondrosarcoma.
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I can take care of myself and perform daily activities.
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My scans show no signs of cancer spread.
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My blood tests show enough white cells and platelets.
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My cancer originates in my skull or spine.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~90 days
This trial's timeline: 3 weeks for screening, Varies for treatment, and 90 days for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Acute Toxicity
Chondrosarcoma
Secondary outcome measures
Late toxicity

Side effects data

From 2020 Phase 2 trial • 275 Patients • NCT00915005
73%
Fatigue
71%
Radiation Induced Dermatitis
52%
Esophatitis
49%
Cough
45%
Dyspnea
38%
Dysphagia
33%
Odynophagia
30%
Anorexia
24%
Pneumonitis
12%
Pleural effusion
8%
Dehydration
8%
Pneumonia
5%
Pulmonary fibrosis
4%
Fever
2%
Pericardial effusion
2%
Gastro Stricutre
1%
Cardiac Ischemia / Infarction
1%
Hypoxia
100%
80%
60%
40%
20%
0%
Study treatment Arm
Intensity-modulated (Photon) Radiotherapy (IMRT)
Passive Scattering Proton Therapy (PSPT)

Trial Design

1Treatment groups
Experimental Treatment
Group I: Proton groupExperimental Treatment1 Intervention
Proton radiation total dose 72.00 to 79.2 Gy(RBE) in 40-44 fractions
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Proton Therapy
2009
Completed Phase 2
~280

Find a Location

Who is running the clinical trial?

Abramson Cancer Center at Penn MedicineLead Sponsor
387 Previous Clinical Trials
145,645 Total Patients Enrolled
Abramson Cancer Center of the University of PennsylvaniaLead Sponsor
359 Previous Clinical Trials
105,045 Total Patients Enrolled

Media Library

Proton Therapy (Proton Beam Therapy) Clinical Trial Eligibility Overview. Trial Name: NCT01449149 — N/A
Chordoma Research Study Groups: Proton group
Chordoma Clinical Trial 2023: Proton Therapy Highlights & Side Effects. Trial Name: NCT01449149 — N/A
Proton Therapy (Proton Beam Therapy) 2023 Treatment Timeline for Medical Study. Trial Name: NCT01449149 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is this research endeavor currently taking in participants?

"Per the data available on clinicaltrials.gov, this medical trial is not currently recruiting new patients. The study was first posted in March 2010 and last updated June 2022; however, 48 other trials are still actively seeking participants at present."

Answered by AI

Who else is applying?

What site did they apply to?
Abramson Cancer Center of the University of Pennsylvania
What portion of applicants met pre-screening criteria?
Met criteria
How many prior treatments have patients received?
1

What questions have other patients asked about this trial?

Do I have to pay for the treatment? How long will my treatment process take?
PatientReceived 2+ prior treatments
Recent research and studies
clinicaltrials.govStudy
Proton Radiation for Chordomas and Chondrosarcomas
2010. "Proton Radiation for Chordomas and Chondrosarcomas". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT01449149.
All > Osa > Chordoma
~8 spots leftby Dec 2026
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