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Chemotherapy Switch + Losartan for Pancreatic Cancer
Study Summary
This trial is testing whether an early switch from one chemotherapy regimen to another, plus the drug losartan, is effective in treating patients with pancreatic cancer.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Side effects data
From 2016 Phase 2 trial • 60 Patients • NCT00096226Trial Design
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Who is running the clinical trial?
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- I have never had chemotherapy for pancreatic cancer.My cancer has spread to distant parts of my body.I haven't had a laparoscopy to diagnose my condition.My kidney function is normal or only slightly reduced.My bilirubin levels are within the normal range or improving after a biliary procedure.I have had fainting spells, irregular heartbeats, or sudden cardiac arrest due to heart issues.My hemoglobin is above 9 g/dL and I haven't had a blood transfusion in the last 28 days.I have another cancer with less than a 90% chance of being cured.I am considered fit for surgery aimed at curing my condition.I am fully active or can carry out light work.Your absolute neutrophil count is at least 1000 cells per cubic millimeter.I have taken a pregnancy test in the last 72 hours and it was negative.My scans show no signs of cancer spread before joining the study or before receiving one standard treatment cycle.I have not had major surgery in the last 4 weeks.I am 18 years old or older.Your platelet count is at least 100,000 per mm^3.You have had bad reactions to the study drugs or their ingredients in the past.Your blood pressure is higher than 100 mm Hg before starting the study.I am not using any other cancer treatments not allowed in this study.Your AST and ALT levels in the blood are not more than 2.5 times the upper limit of normal.I have health conditions that make surgery too risky for me.I agree to use birth control if I can have children.My diagnosis of pancreatic cancer is confirmed by lab tests.I agree to use effective birth control during the study.I have had only one round of chemotherapy or less for my pancreatic cancer.My pancreatic cancer is either operable, borderline operable, or advanced but not spread far.I am currently taking ACE inhibitors or ARB medications.
- Group 1: Treatment (mFOLFIRINOX, chemotherapy)
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
What risks are associated with Resection?
"Although Phase 2 trials have not yet yielded data on efficacy, there is some evidence supporting Resection's safety. Therefore, it received a score of 2."
How many individuals are enrolled in this clinical trial?
"That is correct. The clinicaltrials.gov website indicates that this study has an active recruitment status. This trial was originally posted on May 27th, 2021 and updated on August 25th, 2022. They are looking to enroll 60 patients at a single site."
What are the other medical procedures that commonly use Resection?
"Currently, there are 924 Resection trials underway. 277 of those studies are in their final Phase 3 stage. The majority of the research is based in Guangzhou, Guangdong; however, there are 34568 locations conducting these investigations."
What kind of medical conditions does Resection commonly target?
"Patients with kidney failure, refractory fallopian tube carcinoma, and small cell lung cancer (sclc) can explore Resection as a possible treatment option."
Are there any vacancies in this research project for new participants?
"From what is detailed on clinicaltrials.gov, this research project is currently seeking volunteers. This trial was originally posted on May 27th, 2021 and was most recently updated on August 25th, 2022."
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