Repetitive Transcranial Magnetic Stimulation for Stimulant Use Disorder
(VA-StARTS Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests a new treatment called repetitive transcranial magnetic stimulation (rTMS) for individuals with stimulant use disorder (SUD). Currently, no FDA-approved treatments like this exist for SUD, so researchers aim to determine if rTMS can help. The trial includes two groups: one receiving real rTMS and the other a placebo for comparison. Veterans with a confirmed severe SUD diagnosis, who have not used stimulants for more than 8 weeks and are on stable medication, may be suitable candidates for this study. As an unphased trial, this study offers a unique opportunity to contribute to groundbreaking research in a field with limited treatment options.
Do I have to stop taking my current medications for the trial?
You can continue taking your current medications as long as they have been stable for at least 2 weeks before the study and remain unchanged during the treatment phase. However, if you are on certain medications that lower the seizure threshold, like clozapine or high doses of bupropion, you may not be eligible to participate.
What prior data suggests that this technique is safe for treating stimulant use disorder?
Studies have shown that repetitive transcranial magnetic stimulation (rTMS) is generally safe when used correctly. Research involving many participants has found that rTMS is well-tolerated. However, some people experienced mild side effects like neck pain, and in rare cases, seizures.
These side effects are more likely if the treatment does not follow approved guidelines. Therefore, proper screening of participants before starting rTMS is crucial. When performed correctly, rTMS has been safely used in many studies. Those considering this treatment should discuss potential risks with a healthcare provider.12345Why are researchers excited about this trial?
Repetitive Transcranial Magnetic Stimulation (rTMS) is unique because it offers a non-invasive approach to treating Stimulant Use Disorder, which sets it apart from conventional options like behavioral therapies or medication-assisted treatments. Unlike standard treatments that typically focus on managing withdrawal symptoms or reducing cravings through medication, rTMS uses magnetic fields to stimulate specific areas of the brain involved in addiction. Researchers are excited about rTMS because it has the potential to directly alter brain activity patterns associated with addiction, offering a novel pathway for recovery that doesn't rely on pharmaceuticals.
What evidence suggests that repetitive transcranial magnetic stimulation is effective for stimulant use disorder?
Research shows that repetitive transcranial magnetic stimulation (rTMS) may help treat stimulant use disorder. This trial will assign participants to receive either active rTMS or sham rTMS. Some studies have found that patients experienced fewer drug cravings and improvements in mood and anxiety. One study found that rTMS led to lasting reductions in cocaine use, while another suggested it might help reduce cravings for amphetamines. Although rTMS is not yet widely approved for treating stimulant use disorder, these early results are promising.16789
Who Is on the Research Team?
Jong H. Yoon, MD
Principal Investigator
VA Palo Alto Health Care System, Palo Alto, CA
Are You a Good Fit for This Trial?
This trial is for veterans with stimulant use disorder (SUD) who are seeking treatment. Specific eligibility criteria details were not provided, so it's important to contact the study organizers for more information on who can participate.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive either active or sham repetitive transcranial magnetic stimulation (rTMS) for stimulant use disorder
Follow-up
Participants are monitored for safety and effectiveness after treatment, including relapse rates and reward circuit function
What Are the Treatments Tested in This Trial?
Interventions
- Repetitive Transcranial Magnetic Stimulation (rTMS)
Find a Clinic Near You
Who Is Running the Clinical Trial?
VA Office of Research and Development
Lead Sponsor
Stanford University
Collaborator