Study Summary
This trial is designed to provide itacitinib to people who have already been taking it and who may benefit from continued treatment. Eligible participants will receive the same dose and schedule of itacitinib as they received in the previous study. Treatment may be continued as long as the participant does not experience negative side effects, still derives benefit from the drug, and does not meet any other criteria for discontinuation.
- Chronic Graft-versus-Host Disease
- Bronchiolitis Obliterans
- Myelofibrosis
Treatment Effectiveness
Phase-Based Effectiveness
Study Objectives
1 Primary · 0 Secondary · Reporting Duration: 3 years
Trial Safety
Phase-Based Safety
Awards & Highlights
Trial Design
1 Treatment Group
itacitinib
1 of 1
Experimental Treatment
100 Total Participants · 1 Treatment Group
Primary Treatment: itacitinib · No Placebo Group · Phase 2
Trial Logistics
Trial Timeline
Who is running the clinical trial?
Eligibility Criteria
Age 18+ · All Participants · 0 Total Inclusion Criteria
Mark “Yes” if the following statements are true for you:Frequently Asked Questions
Does this research endeavor introduce a novel approach to the field?
"The pharmaceutical Incyte Corporation has been researching itacitinib since 2013, conducting 23 trials across 20 countries and 76 cities. To date, 12 of these studies have concluded, with the earliest trial containing 121 patients who were able to successfully complete Phase 1 drug approval." - Anonymous Online Contributor
How many healthcare institutions are participating in this research endeavor?
"City of Hope National Medical Center in Duarte, Temple University in Cleveland and the Cleveland Clinic Vancouver are amongst 8 sites running this trial. There is also a selection of other clinical centres hosting this study." - Anonymous Online Contributor
Has the FDA given its approval to itacitinib?
"There is some evidence for itacitinib's safety, yet no proof of efficacy. For this reason, our team at Power gave a rating of 2 to its safety profile." - Anonymous Online Contributor
Is the enrollment of participants open in this investigation?
"Affirmative. Clinicaltrials.gov confirms that this trial is actively searching for participants, which began on March 10th 2021 and was amended most recently in November 15th 2022. This medical study requires the enrollment of 100 individuals across 8 research sites." - Anonymous Online Contributor
Has itacitinib been tested in prior experiments?
"Currently, 23 clinical trials are being conducted on itacitinib. One of these is in the final phase 3 stage. The majority of studies take place at research sites within Philadelphia, Pennsylvania, but there are a total of 397 locations evaluating this medication's efficacy and safety." - Anonymous Online Contributor
How many participants are participating in this research endeavor?
"Affirmative, the information on clinicaltrials.gov verifies that this experiment is in need of volunteers - it was initially posted on March 10th 2021 and updated most recently on November 15 2022. 100 participants are expected to join at 8 different medical centres." - Anonymous Online Contributor