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Phytochemical
Sulforaphane for Skin Aging
Phase < 1
Recruiting
Led By Anna Chien
Research Sponsored by Johns Hopkins University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Participants must be over the age of 18 years old with healthy skin or moderate degree of photoaging/intrinsic aging
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 6 months
Awards & highlights
Study Summary
This trial will compare how two types of keratin respond to a compound called sulforaphane, and whether this has any effect on skin aging or exposure to light.
Who is the study for?
This trial is for adults over 18 with healthy skin or moderate photoaging, who can undergo a skin biopsy and light exposure. They must understand the study and agree to follow its rules. People with recent drug trials, broccoli allergies, steroid or retinoid treatments, bleeding disorders, excessive scarring tendencies, pregnancy/nursing status, anesthesia allergies or significant medical issues are excluded.Check my eligibility
What is being tested?
The trial tests how sulforaphane (a compound from broccoli) affects skin aging when applied before exposing the skin to UV and visible light. Researchers will look at changes in specific proteins (keratin 16 & 17) in protected vs. exposed skin areas to assess any impact on aging.See study design
What are the potential side effects?
Potential side effects of topical sulforaphane may include local irritation or allergic reactions where it's applied. The procedure itself might cause discomfort during biopsies and temporary redness or sensitivity due to light exposure.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I am over 18 and have healthy skin or some signs of aging.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ up to 6 months
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 6 months
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
keratin 16 fold change as determined by Reverse Transcription Polymerase Chain Reaction (RT-PCR)
keratin 16 presence as determined by immunofluorescence assay
keratin 17 fold change as determined by RT-PCR
+1 moreSecondary outcome measures
keratin expression changes as determined by RT-PCR
Trial Design
2Treatment groups
Active Control
Group I: Sulforaphane without light challengeActive Control1 Intervention
Participants with moderate photodamage and moderate intrinsic skin aging will apply sulforaphane (broccoli sprout extract) in jojoba oil nightly (without any UV or visible light irradiation) for up to 6 months and have up to 9 biopsies taken just before treatment and occurring at regular intervals during the study
Group II: Sulforaphane with light challengeActive Control2 Interventions
Participants will have 2 test areas irradiated with up to 5 UV or visible light treatments and biopsies taken before and within 7 days after UV or visible light irradiation; one of the UV/visible light treated areas will be pre-treated with sulforaphane (broccoli sprout extract) for up to 28 consecutive nights and the other UV/visible light treated areas will be pre-treated with jojoba oil.
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Who is running the clinical trial?
Johns Hopkins UniversityLead Sponsor
2,263 Previous Clinical Trials
14,823,045 Total Patients Enrolled
1 Trials studying Skin Aging
Anna ChienPrincipal InvestigatorDepartment of Dermatology, Johns Hopkins School of Medicine
3 Previous Clinical Trials
159 Total Patients Enrolled
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Eligibility Criteria:
This trial includes the following eligibility criteria:- I am considered healthy enough for skin biopsy and study procedures.I do not have skin conditions that could interfere with clinical tests.I can understand and talk with my doctor.I am healthy enough for skin biopsy, light treatment, and study procedures.I have had excessive scarring or keloids in the last 10 years.I am over 18 and have healthy skin or some signs of aging.I haven't used topical steroids, retinoids, or similar drugs in the last 2 weeks.I might have a bleeding disorder that could make a biopsy risky.I have not taken systemic retinoids or steroids in the last month.I am unable to understand and give consent for my treatment.I am over 18 and have healthy skin or some signs of aging.I can understand and talk with my doctor.
Research Study Groups:
This trial has the following groups:- Group 1: Sulforaphane without light challenge
- Group 2: Sulforaphane with light challenge
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Are there any openings for participation in this research project?
"Affirmative. Per the details on clinicaltrials.gov, this experiment is still searching for participants that meet its enrollment criteria. It was initially posted in October 2019 and last updated in June 2022; it aims to recruit 120 people from a single site."
Answered by AI
How many participants have been included in this medical trial thus far?
"Affirmative. Clinicaltrials.gov records show that this research programme, initially listed on October 9th 2019, is still in need of participants. 120 individuals are required to be enrolled across a single clinical site."
Answered by AI
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