Sleep and Light Therapy for Circadian Rhythm Disorder
(CARRS-P2 Trial)
Trial Summary
What is the purpose of this trial?
Adolescence is a time of heightened reward sensitivity and greater impulsivity. On top of this, many teenagers experience chronic sleep deprivation and misalignment of their circadian rhythms due to biological shifts in their sleep/wake patterns paired with early school start times. Many studies find that this increases the risk for substance use (SU). However, what impact circadian rhythm and sleep disruption either together or independently have on the neuronal circuitry that controls reward and cognition, or if there are interventions that might help to modify these disruptions is unknown. Project 2 (P2) of the CARRS center will test an innovative and mechanistic model of brain circuitry that uses multi-method approaches, takes a developmental perspective, and incorporates key sleep and reward constructs.
Will I have to stop taking my current medications?
The trial does not specify if you must stop taking your current medications, but it excludes those who have changed their psychotropic medications in the 2 weeks before joining or plan major changes during the study. It also excludes those on medications that increase sensitivity to blue light.
What data supports the effectiveness of the treatment 'Sleep and Light Therapy for Circadian Rhythm Disorder'?
Research shows that light therapy, which is part of this treatment, can improve sleep quality and timing in people with circadian rhythm disorders and certain psychiatric conditions. Additionally, studies on similar therapies, like triple chronotherapy, have shown rapid improvements in mood and sleep patterns, suggesting potential benefits for managing circadian rhythm disorders.12345
Is light therapy safe for treating circadian rhythm disorders?
How does sleep and light therapy differ from other treatments for circadian rhythm disorder?
Sleep and light therapy is unique because it uses controlled exposure to light and darkness to adjust the body's internal clock, which can improve sleep patterns and mood. Unlike medications, this treatment focuses on natural environmental cues to regulate circadian rhythms, making it a non-invasive option for managing sleep disorders.134711
Research Team
Brant Hasler, PhD
Principal Investigator
University of Pittsburgh
Eligibility Criteria
This trial is for healthy teens typically enrolled in high school, who go to bed later than 11:15 PM and are not homeschooled. They can't have metal in their body, be pregnant, have unstable medical conditions, recent changes to psychotropic meds, extreme late sleep patterns, frequent headaches or migraines, a history of substance use or serious psychiatric disorders.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Observational Study
Participants undergo 2 weeks of home sleep monitoring followed by an overnight laboratory visit for assessments
Experimental Manipulation
Participants in the Late group undergo sleep and circadian rhythm manipulation for approximately 2 weeks
Follow-up
Participants are monitored for changes in sleep and substance use every 6 months
Treatment Details
Interventions
- Decrease evening blue light
- Increase morning bright light
- Monitor sleep, mood, and substance use
- Sleep Scheduling
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Pittsburgh
Lead Sponsor
National Institute on Drug Abuse (NIDA)
Collaborator