Handgrip Exercise for Chronic Kidney Disease
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial aims to determine if handgrip exercises at home can lower blood pressure in individuals with chronic kidney disease (CKD). Researchers seek to understand why blood pressure increases at rest and during exercise by examining factors like adrenaline levels and blood vessel expansion. The study will include one group performing real isometric handgrip exercise training and another doing a sham version, both over eight weeks. Individuals with CKD who have stable kidney function and do not exercise regularly may be suitable candidates. As an unphased trial, this study provides a unique opportunity to enhance understanding of non-drug interventions for managing blood pressure in CKD.
Do I need to stop my current medications to join the trial?
The trial does not specify if you need to stop taking your current medications, but it does exclude those on certain treatments like central alpha agonists and MAO inhibitors. It's best to discuss your specific medications with the trial team.
What prior data suggests that this handgrip exercise is safe for patients with chronic kidney disease?
Research has shown that isometric handgrip exercises can safely improve health in people with chronic kidney disease (CKD). One study found that these exercises, combined with deep breathing, increased chest expansion and handgrip strength. Participants generally tolerated these exercises well, reporting no major problems or side effects.
Another review of exercise programs for people with CKD highlighted potential benefits, such as slowing disease progression and improving quality of life. Exercise is often recommended for its health benefits, and isometric handgrip training appears to be a suitable option.
While these studies suggest the exercise is safe, consulting a healthcare provider before starting any new exercise routine is always wise, especially for those with health conditions like CKD.12345Why are researchers excited about this trial?
Researchers are excited about isometric handgrip exercise training for chronic kidney disease because it offers a simple, non-invasive approach that patients can do at home. Unlike traditional treatments that often involve medications like ACE inhibitors or dialysis, this exercise protocol focuses on strengthening the body through regular, low-impact workouts. The unique feature here is that it empowers patients to actively participate in their own treatment through a straightforward exercise regimen. By potentially improving cardiovascular health and reducing blood pressure, this method could complement existing treatments and improve overall quality of life for those with chronic kidney disease.
What evidence suggests that isometric handgrip exercise training might be an effective treatment for chronic kidney disease?
Research has shown that isometric handgrip exercises can benefit people with chronic kidney disease (CKD). Some studies have found that these exercises can strengthen grip and improve quality of life. They might also help lower blood pressure, which is crucial for people with CKD as it can slow disease progression and aid in managing other health issues. Although specific data on the extent of blood pressure reduction is limited, research strongly supports the overall benefits of exercise for people with CKD. Participants in this trial will undergo either an 8-week isometric handgrip training protocol or a sham training protocol to evaluate these potential benefits.23567
Who Is on the Research Team?
Jeanie Park, MD
Principal Investigator
Emory University
Are You a Good Fit for This Trial?
This trial is for adults aged 45-85 with chronic kidney disease (CKD) stages IIIa and IV, who don't exercise regularly. They must have stable kidney function without significant changes in the past three months. People who are already active or have unstable CKD cannot participate.Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants perform isometric handgrip exercises at home for 8 weeks, with a frequency of three sessions per week
Follow-up
Participants are monitored for changes in blood pressure and other health markers after the intervention
What Are the Treatments Tested in This Trial?
Interventions
- Isometric Handgrip Exercise Training
Find a Clinic Near You
Who Is Running the Clinical Trial?
Emory University
Lead Sponsor
American Heart Association
Collaborator