This trial is evaluating whether Belzutifan will improve 4 primary outcomes and 3 secondary outcomes in patients with Carcinoma, Renal Cell. Measurement will happen over the course of Up to ~21 days.
This trial requires 52 total participants across 4 different treatment groups
This trial involves 4 different treatments. Belzutifan is the primary treatment being studied. Participants will be divided into 4 treatment groups. There is no placebo group. The treatments being tested are in Phase 1 and are in the first stage of evaluation with people.
"The long-term survival of an allopurinol-treated patient who developed renal cell carcinoma and survived 5 years without cancer treatment was reported. The current study was retrospective." - Anonymous Online Contributor
"Both the use of chemotherapy and radiotherapy have a large effect on survival. However chemotherapy appears to offer slightly higher chance of survival in terms of time to relapse, disease progression, and overall survival." - Anonymous Online Contributor
"The features associated with carcinoma of the kidney vary among tumours, and the presence and nature of these features can affect clinical management recommendations and can be used as a guide to the identification and grading of renal cell carcinomas." - Anonymous Online Contributor
"Carcinoma, is the commonest form of kidney cancer. It is usually very treatable. It typically begins in the parenchyma of the kidney. The 5 year survival rate is 80%, but for most patients it is only 10-15% with most deaths occurring in the late stages." - Anonymous Online Contributor
"Although it is unknown what causes carcinoma, renal cell carcinoma occurs as a result of an alteration in the DNA of the cell. This may produce abnormal proteins or cause cells to proliferate beyond their normal level." - Anonymous Online Contributor
"In 2003, 3.9 million Americans had carcinoma (skin and nonmelanoma), and 1.2 million had renal cell carcinomas. In the 1990s, there appeared to be a stable, albeit low, prevalence of renal cell cancer in the United States. However, trends in carcinoma and renal cell cancer incidence are not clear at this time." - Anonymous Online Contributor
"There have been several recent studies reporting the potential mechanisms of therapeutic benefit of some botanical compounds to treat renal cell carcinoma. The use of some botanical compounds may be helpful in the treatment of renal cell carcinoma." - Anonymous Online Contributor
"A study was conducted between 2016 and 2018 to observe the effects of cancer and renal cancer on patients' brain activity. In a recent study, findings determined that the development of cancer and kidney cancer causes different brain responses of different patients. To explain these differences, future treatment options are essential. Although this work will continue, there are some potential treatment options that future research may result in. One treatment option that could potentially be used in conjunction with kidney transplantation for cancer is a kidney transplantation procedure called bilateral kidney transplantation. This procedure can be beneficial for patients with cancer because their existing kidney can be replaced with a new kidney that has been genetically modified to have its own immune system, reducing the possibility of rejection." - Anonymous Online Contributor
"Belzuthan may increase caspase-3 levels and induce apoptosis in kidney cancer cells. The induction by belzuthan of apoptosis may be related to the inhibition of Akt phosphorylation and its activity, as well as to the decreased expression of survivin protein levels in cells. Furthermore, the activity of belzuthan may be increased at low doses. Future research with similar strategies must be pursued to understand cell death induced by belzuthan." - Anonymous Online Contributor
"The main causes of RCC, based on the results of the present study, were the following. 1. Infection by the parasite (except schistosoms) was the single cause of bladder carcinoma and the second cause of renal carcinoma. 2. Radiation was the single cause of renal carcinoma. 3. A combination of viral and nonviral infection caused renal carcinoma. 4. Tobacco smoking was the single cause of RCC. 5. A history of the following diseases/accidents/factors were the causes of renal carcinoma. Liver cirrhosis caused renal carcinoma. Radiation therapy was the cause of renal carcinoma. An immune complex of viral and nonviral infection caused renal carcinoma." - Anonymous Online Contributor
"Although the mean duration of the disease was 10.5 months, the actual duration was longer, i.e. more than 6 months. The metastases were localised, i.e. renal cell carcinoma. This led to the treatment regimen being a combination of the VD + C and C + P chemotherapy regimens. It also led to a delay in the mean duration of the disease (27 months) in order to wait for the metastases to spread and to provide more effective chemotherapy." - Anonymous Online Contributor
"Elderly and non-elderly patients should be considered for clinical trials for renal cell carcinoma. These trials can reduce the long-term health care costs associated with managing this disease and can improve patient survival." - Anonymous Online Contributor