Ser-Ap-Es

Hypertensive disease
Treatment
1 FDA approval
20 Active Studies for Ser-Ap-Es

What is Ser-Ap-Es

ReserpineThe Generic name of this drug
Treatment SummaryHydrochlorothiazide is a medication used to treat swelling and high blood pressure. It is the most commonly prescribed thiazide diuretic, but its use is declining in favor of drugs such as angiotensin converting enzyme inhibitors and angiotensin II receptor blockers. It was approved by the FDA in 1959 and is available in combination with other drugs.
Ser-Ap-Esis the brand name
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Ser-Ap-Es Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Ser-Ap-Es
Reserpine
1960
8

Approved as Treatment by the FDA

Reserpine, also called Ser-Ap-Es, is approved by the FDA for 1 uses like Hypertensive disease .
Hypertensive disease
Used to treat High Blood Pressure (Hypertension) in combination with Polythiazide

Effectiveness

How Ser-Ap-Es Affects PatientsHydrochlorothiazide helps the body get rid of more water through urine. The amount of hydrochlorothiazide taken will vary from person to person, but is usually between 25-100mg. People with weakened kidney or liver function should be especially careful when taking this drug.
How Ser-Ap-Es works in the bodyHydrochlorothiazide works by preventing the reabsorption of sodium and chloride, which causes water to be excreted from the body. This drug is transported from the blood into the cells lining the distal convoluted tubule in the kidneys, and then sent to the lumen of the tubule. Normally, sodium is reabsorbed into these cells and then pumped out into the bloodstream, causing a concentration gradient that encourages water to be reabsorbed. However, by blocking this reabsorption process, hydrochlorothiazide decreases the concentration gradient and reduces the amount of water that is reabsorbed by the body.

When to interrupt dosage

The suggested dosage of Ser-Ap-Es is contingent upon the identified condition, like Antepartum magnesium sulfate prevention, inadequately regulated blood pressure with single treatment and antihypertensives. The measure of dosage fluctuates in accordance with the technique of administration (e.g. Tablet, coated - Oral or Oral) recorded in the table beneath.
Condition
Dosage
Administration
Hypertensive disease
, 0.1 mg, 0.25 mg, 0.125 mg, 25.0 mg
Oral, Tablet, , Tablet - Oral, Tablet, coated, Tablet, coated - Oral

Warnings

There are 20 known major drug interactions with Ser-Ap-Es.
Common Ser-Ap-Es Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The serum concentration of Abemaciclib can be increased when it is combined with Reserpine.
Amifostine
Major
Reserpine may increase the hypotensive activities of Amifostine.
Amisulpride
Major
Reserpine may increase the antipsychotic activities of Amisulpride.
Astemizole
Major
The metabolism of Astemizole can be increased when combined with Reserpine.
Axitinib
Major
The serum concentration of Axitinib can be increased when it is combined with Reserpine.
Ser-Ap-Es Toxicity & Overdose RiskThe lowest toxic dose of hydrochlorothiazide in mice and rats has been found to be greater than 10g/kg. Those who overdose on the drug may experience low levels of potassium, chloride, and sodium in the blood. To treat these symptoms, supportive care including fluids and electrolytes is recommended, as well as vasopressors to treat hypotension and oxygen for respiratory impairment.
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Ser-Ap-Es Novel Uses: Which Conditions Have a Clinical Trial Featuring Ser-Ap-Es?

158 active clinical trials are currently examining the potential of Ser-Ap-Es in providing relief from Cirrhosis, Edema and Congestive Heart Failure.
Condition
Clinical Trials
Trial Phases
Hypertensive disease
28 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3

Ser-Ap-Es Reviews: What are patients saying about Ser-Ap-Es?

5Patient Review
1/29/2019
Ser-Ap-Es for High Blood Pressure
This drug has been the most effective in lowering my blood pressure to a normal level. I have tried many different drugs, but none of them have been as successful as this one.
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Patient Q&A Section about ser-ap-es

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Clinical Trials for Ser-Ap-Es

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Cuffless PPG Monitor for High Blood Pressure

18+
All Sexes
Miami, FL
This study aims to validate the accuracy and reliability of blood pressure (BP) estimates obtained over 24 hours using a PPG-based chest-patch device compared to the gold standard ambulatory blood pressure monitoring (ABPM) method using an upper arm cuff-based oscillometric BP device, in both hypertensive and normotensive individuals referred by their provider to undergo a 24-hours ABPM for clinical indication. The Awake/Asleep test, which is the primary test recommended for automated wearable cuffless BP devices that are cuff-calibrated (based on the 2023 European Society of Hypertension (ESH) recommendations for the validation of cuffless blood pressure measuring devices), will be conducted in this study. The secondary aim of the study is to assess the feasibility and convenience of the PPG-based device.
Waitlist Available
Has No Placebo
U Health (+1 Sites)Ziad Zoghby, M.D., M.B.A.Biobeat Technologies Ltd.
Have you considered Ser-Ap-Es clinical trials? We made a collection of clinical trials featuring Ser-Ap-Es, we think they might fit your search criteria.Go to Trials
Have you considered Ser-Ap-Es clinical trials? We made a collection of clinical trials featuring Ser-Ap-Es, we think they might fit your search criteria.Go to Trials
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Egg White Powder for High Blood Sugar and High Blood Pressure

18 - 70
All Sexes
Edmonton, Canada
Bioactive peptides derived from food proteins show potential for improving human health. One of such promising peptides is namely IRW made from egg white hydrolysate and composed of three peptides. This is a feasibility study to assess the acute effect of IRW in egg white hydrolysate for the management of high sugar and blood pressure. Participants at high risk of type 2 diabetes (T2D) or having T2D will undergo 4 consecutive treatments of 1 day each (randomly), during which they will consume a standardized breakfast with a smoothie containing different protein powders. Each treatment will be separated by a minimum of 1-week. Participants in the healthy control group will undergo 1 treatment only (one day).
Phase 1
Waitlist Available
University of AlbertaJianping Wu, PhD
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CardioCare Quest for High Blood Pressure

18+
All Sexes
Flagstaff, AZ
This project aims to address healthcare disparities among Navaho people diagnosed with hypertension or prehypertension through three main objectives. Firstly, it identifies and shares insights on healthcare access disparities affecting Navaho individuals experiencing nonadherence to hypertension treatment. Secondly, the proposal develops a telehealth solution based on factors identified as knowledge gaps caused by healthcare access disparities in hypertension management; we will use the factors to design a series of engaging minigames that can be incorporated into the larger CardioCare Quest. These minigames will be co-designed with end users and clinicians. Finally, the proposal conducts comprehensive qualitative and quantitative assessments of user experiences, perceptions, and challenges with CardioCare Quest.
Recruiting
Has No Placebo
Northern Arizona University (+1 Sites)Tochukwu Ikwunne, PhD
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Food as Medicine for Cardiometabolic Health

18+
All Sexes
Boston, MA
Though the Mississippi Delta has a rich agricultural history and some of the nation's most fertile soil, residents have experienced the legacy of slavery and economic exploitation through food insecurity and poverty for generations. This project focuses on Bolivar, Washington, and Sunflower, contiguous counties in the Delta that are designated as health disparity populations. Over 65% of the 100,000 residents are Black/African American and \~30% live at or below the poverty level. Obesity rates are high and the rate of diabetes is almost double the national average. Tufts University received a grant from the National Institute of Minority Health and Health Disparities to develop, test, and evaluate a Food is Medicine program in Mississippi. The Delta Growing a Resilient, Enriching, Equitable, Nourishing food System (GREENS) Food is Medicine (FIM) Project, is a collaborative project in Bolivar, Washington, and Sunflower counties in Mississippi. The intervention involves regularly distributed fruit and vegetable produce boxes as well as nutrition education materials to the intervention group. The control group will receive produce boxes later, after they complete study activities. The project's primary goal is to improve health outcomes by creating a FIM intervention. The Delta GREENS FIM Project aims to become a model for promoting nutrition security and management of chronic conditions in varied communities nationwide.
Recruiting
Has No Placebo
Tufts UniversityChristina D Economos, PhD
Have you considered Ser-Ap-Es clinical trials? We made a collection of clinical trials featuring Ser-Ap-Es, we think they might fit your search criteria.Go to Trials
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