Norepinephrine and epinephrine for Shock

Phase-Based Progress Estimates
University of Chicago Medical Center, Chicago, ILShockNorepinephrine - Drug
All Sexes
What conditions do you have?

Study Summary

This trial is testing whether two drugs are better than two other drugs at reducing heart rhythm problems in people with shock who haven't responded to IV fluids.

Treatment Effectiveness

Effectiveness Progress

3 of 3
This is further along than 93% of similar trials

Study Objectives

1 Primary · 2 Secondary · Reporting Duration: one month, three months, six months, and twelve months after discharge

1 week
Immune cell function
SIx months
Incidence of tachydysrhythmia
Six months
Discharge location
Duration of mechanical ventilation
Heart rate
Hospital length of stay
Hospital mortality
ICU Complications
ICU length of stay
one month, three months, six months, and twelve months after discharge
Functional status

Trial Safety

Safety Progress

3 of 3
This is further along than 85% of similar trials

Trial Design

2 Treatment Groups

Norepinephrine and epinephrine
1 of 2
Phenylephrine and vasopressin
1 of 2

Active Control

836 Total Participants · 2 Treatment Groups

Primary Treatment: Norepinephrine and epinephrine · No Placebo Group · Phase 4

Norepinephrine and epinephrineActiveComparator Group · 2 Interventions: Norepinephrine, Epinephrine · Intervention Types: Drug, Drug
Phenylephrine and vasopressinActiveComparator Group · 2 Interventions: Phenylephrine, Vasopressin · Intervention Types: Drug, Drug

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: one month, three months, six months, and twelve months after discharge

Who is running the clinical trial?

University of ChicagoLead Sponsor
935 Previous Clinical Trials
753,298 Total Patients Enrolled
3 Trials studying Shock
110 Patients Enrolled for Shock
John P Kress, MDPrincipal InvestigatorUniversity of Chicago
8 Previous Clinical Trials
1,314 Total Patients Enrolled
1 Trials studying Shock
83 Patients Enrolled for Shock

Eligibility Criteria

Age 18+ · All Participants · 2 Total Inclusion Criteria

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Frequently Asked Questions

Are there any risks associated with using Norepinephrine and epinephrine therapeutically?

"This approved treatment has been extensively tested, so its safety rating is a solid 3." - Anonymous Online Contributor

Unverified Answer

What primary roles do Norepinephrine and epinephrine play in modern medical treatment?

"Norepinephrine and epinephrine are typically administered to treat uterine contractions, but they can also be of use for treating laryngotracheobronchitis, eye conditions, and cases of unresponsive bradycardia." - Anonymous Online Contributor

Unverified Answer

How have Norepinephrine and epinephrine been tested in the past through scientific research?

"Currently, 71 studies are researching the efficacy of Norepinephrine and epinephrine medications. Of those active trials, 15 have entered Phase 3 testing. Though concentrated in Los Angeles, California - these clinical trials take place at 120 different locations across the USA." - Anonymous Online Contributor

Unverified Answer

How many participants has this trial recruited thus far?

"Affirmative. The latest information on exhibits that this medical trial is actively enrolling participants, beginning from May 1st 2014 and last updated December 21 2022. 836 patients are needed for the research at one established site of study." - Anonymous Online Contributor

Unverified Answer

Is this experiment recruiting participants currently?

"Affirmative. has updated information that this experiment is presently enrolling participants, who were initially posted on May 1st 2014. 836 patients are intending to be recruited at one location." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.