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Vasoactive Drugs for Shock
Study Summary
This trial is testing whether two drugs are better than two other drugs at reducing heart rhythm problems in people with shock who haven't responded to IV fluids.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
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- I need strong medication through a vein for severe low blood pressure.I have severe failure of the right side of my heart.I have never had a cardiopulmonary arrest.I am 18 years old or older.
- Group 1: Norepinephrine and epinephrine
- Group 2: Phenylephrine and vasopressin
- Approved for 20 Other Conditions - This treatment demonstrated efficacy for 20 other conditions.
- Drug Has Already Been Approved - The FDA has already approved this drug, and is just seeking more data.
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Pivotal Trial - The final step before approval, pivotal trials feature drugs that have already shown basic safety & efficacy.
- All Individual Drugs Already Approved - Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Are there any risks associated with using Norepinephrine and epinephrine therapeutically?
"This approved treatment has been extensively tested, so its safety rating is a solid 3."
What primary roles do Norepinephrine and epinephrine play in modern medical treatment?
"Norepinephrine and epinephrine are typically administered to treat uterine contractions, but they can also be of use for treating laryngotracheobronchitis, eye conditions, and cases of unresponsive bradycardia."
How have Norepinephrine and epinephrine been tested in the past through scientific research?
"Currently, 71 studies are researching the efficacy of Norepinephrine and epinephrine medications. Of those active trials, 15 have entered Phase 3 testing. Though concentrated in Los Angeles, California - these clinical trials take place at 120 different locations across the USA."
How many participants has this trial recruited thus far?
"Affirmative. The latest information on clinicaltrials.gov exhibits that this medical trial is actively enrolling participants, beginning from May 1st 2014 and last updated December 21 2022. 836 patients are needed for the research at one established site of study."
Is this experiment recruiting participants currently?
"Affirmative. Clinicaltrials.gov has updated information that this experiment is presently enrolling participants, who were initially posted on May 1st 2014. 836 patients are intending to be recruited at one location."
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