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Procedure

Weight Loss Surgery for Obesity

N/A
Recruiting
Led By Michael D Jensen, MD
Research Sponsored by Mayo Clinic
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Mo active physical illness that would interfere with mobility or weight loss after bariatric surgery
No active physical illness that would interfere with mobility or weight loss after bariatric surgery
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 1 year
Awards & highlights

Study Summary

This trial will test the effects of weight loss surgery on inflammation and lipolysis regulation.

Who is the study for?
This trial is for adults with severe obesity (BMI 40-50) who haven't been exercising regularly or taking certain medications that affect fat metabolism. It's not for those with active physical illnesses, liver disease, diabetes, kidney issues, heart disease, smokers, or pregnant/breastfeeding individuals.Check my eligibility
What is being tested?
The study investigates how well bariatric surgery (sleeve gastrectomy) helps people lose a lot of weight and improves the way their bodies use insulin to break down fats. Researchers will compare inflammation and fat breakdown before and after surgery.See study design
What are the potential side effects?
Potential side effects from gastric sleeve surgery can include pain at the incision site, nausea, vomiting, acid reflux, nutritional deficiencies due to reduced food intake capacity and changes in digestion.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I don't have any illnesses that would stop me from moving around or losing weight after weight-loss surgery.
Select...
I don't have any illnesses that would stop me from moving around or losing weight after weight-loss surgery.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~1 year
This trial's timeline: 3 weeks for screening, Varies for treatment, and 1 year for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
adipose macrophage content, adipose IL-6 and TNF gene expression
insulin regulation of lipolysis (IC50)
Secondary outcome measures
adipocyte perilipin 1 and HSL and ATGL
Other outcome measures
Long-term, substantial weight loss and insulin regulation of lipolysis

Trial Design

1Treatment groups
Experimental Treatment
Group I: Gastric sleeve surgeryExperimental Treatment1 Intervention
before and after weight loss from bariatric surgery

Find a Location

Who is running the clinical trial?

Mayo ClinicLead Sponsor
3,191 Previous Clinical Trials
3,758,455 Total Patients Enrolled
85 Trials studying Obesity
14,723 Patients Enrolled for Obesity
Michael D Jensen, MDPrincipal InvestigatorMayo Clinic
3 Previous Clinical Trials
116 Total Patients Enrolled
1 Trials studying Obesity
48 Patients Enrolled for Obesity

Media Library

Gastric Sleeve/Bariatric Surgery (Procedure) Clinical Trial Eligibility Overview. Trial Name: NCT03868592 — N/A
Obesity Research Study Groups: Gastric sleeve surgery
Obesity Clinical Trial 2023: Gastric Sleeve/Bariatric Surgery Highlights & Side Effects. Trial Name: NCT03868592 — N/A
Gastric Sleeve/Bariatric Surgery (Procedure) 2023 Treatment Timeline for Medical Study. Trial Name: NCT03868592 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is it feasible to be a participant in this clinical trial?

"Individuals who possess obesity, morbidity and are in the age range of 18-65 years old may qualify to join this clinical trial. Up to 30 people will be accepted into this research program."

Answered by AI

Are there any vacancies for participants in this investigation?

"This trial, which was initially uploaded to clinicaltrials.gov on August 1st 2019 and last updated on November 29th 2021 is currently inviting applicants."

Answered by AI

Does this research protocol permit seniors over 45 to participate?

"Individuals aged 18 to 65 are the only eligible participants for this medical trial. Moreover, there are 23 other trials specifically designed for minors and 235 clinical studies tailored towards senior citizens."

Answered by AI

How many people is the trial recruiting for participation?

"Affirmative. According to clinicaltrials.gov, this ongoing medical trial was first made available on August 1st 2019 and has since been updated in November 2021. 30 participants need to be sourced from a single designated site for the study's completion."

Answered by AI

Who else is applying?

What state do they live in?
Iowa
Wisconsin
What site did they apply to?
Mayo Clinic
What portion of applicants met pre-screening criteria?
Met criteria
How many prior treatments have patients received?
1

Why did patients apply to this trial?

I was an athlete for the better part of my youth and early adulthood. After college I have struggled with my weight loss and “dieting “ isn’t the solution that fits for me and I want to be more active and not feel aches that prevent me from wanting to be more active with my kids. I want to live longer and have a fuller life and I am not ashamed to say I need help reaching those goals.
PatientReceived 1 prior treatment
~1 spots leftby May 2024